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Your environment affects how well your medications work − identifying exactly how could make medicine better

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theconversation.com – Gary W. Miller, Professor of Environmental Health Sciences, Columbia University Mailman School of Public Health – 2025-02-03 07:30:00

Your environment affects how well your medications work − identifying exactly how could make medicine better

Even the air you breathe may influence how effective a drug may be for you.
Jorg Greuel/Photodisc via Getty Images

Gary W. Miller, Columbia University Mailman School of Public Health

Your genes play a major role in determining your height, hair and eye color, and skin tone, but they don’t tell the entire story of who you are. Your environment is incredibly important in shaping your personality, your likes and dislikes, and your health. In fact, your diet, social interactions, exposure to pollution, physical activity and education often exceed the influence of genetics on many of the features that define you.

Figuring out how your genes and environment increase your likelihood of developing asthma, heart disease, cancer, dementia and other conditions can have life-changing consequences. The field of genomics has made it relatively straightforward to test both in the hospital and at home for a wide range of genetic variations linked to disease risk.

And in recent years, science has been making progress on tracking down the environmental culprits that drive risk for several diseases – and on identifying ways to optimize treatments based on your personal environmental exposures.

Person sorting through pills, a variety of pill bottles and a weekly pill box beside them
Prescribing the most effective treatment from the get-go can reduce harmful drug reactions.
Willie B. Thomas/DigitalVision via Getty Images

My work as a pharmacologist and toxicologist has led me to the emerging science of exposomics – the study of all of the physical, chemical, biological and social factors that affect your biology. While your genome comprises all of the genes that encode your biology, your exposome is a concept that comprises all your environmental exposures. Like how researchers use DNA sequencers to study genomics, scientists in exposomics use chemistry and high-tech sensors to measure the effects of thousands of environmental factors on health.

Medications don’t always work

For many people, standard drug therapies to treat certain conditions simply don’t work. Controlling blood pressure often requires months of trial and error. It can take months or even years to identify an adequate treatment plan for depression.

Adverse events caused by medications account for more than 1 million visits to emergency departments each year in the U.S. What drives these differences in drug effects between patients? Is it their genes? Are they not taking their medication as prescribed due to side effects? Or something else?

As it turns out, your environment can have a major effect on how well specific treatments work for you. Think about the warning labels advising you not to drink grapefruit juice while taking a specific drug, for example. This is because a natural chemical in grapefruit inhibits the enzymes that break down those medications. Some common statins used to control high cholesterol can build up to toxic levels because the chemical in grapefruit juice blocks its normal processing.

Grapefruit isn’t the only environmental factor affecting how you respond to your medications. Over 8,600 chemicals are used in commerce in the U.S., and you are exposed to thousands of these chemicals on a daily basis. It is more likely than not that many of these chemicals can interact with the drugs you take.

Diagram of a person surrounded by icons of the various environmental exposures that make up the exposome
Your exposome encompasses a wide range of factors.
Nathalie Ruaux/Wikimedia Commons, CC BY-SA

Some of the chemicals we use to keep fleas and ticks off pets can actually increase the levels of the same enzyme blocked by grapefruit juice, meaning a statin may be broken down so fast that it doesn’t control elevated cholesterol.

Byproducts from the combustion of organic matter, such as engine exhaust and burning wood, can also interfere with drug-metabolizing enzymes. Some of these chemicals, called polyaromatic hydrocarbons, can inactivate medications used to treat asthma. The environmental factor triggering your asthma could prevent the drugs used to treat it from working.

A chemical solution?

Advances in chemistry are helping researchers figure out what chemicals are getting in the way of treatment.

Your hospital laboratory can already measure dozens of molecules in your blood. Measuring your salt levels can tell doctors how your kidneys are working, cholesterol levels indicate your risk of heart disease, and specific enzymes reveal your liver’s health. These common tests are routine and useful for nearly every patient.

There are many additional tests that can help determine how a specific condition is progressing or responding to therapy. Hemoglobin A1c levels help determine how well glucose levels are being controlled in those with prediabetes or diabetes. And thousands of other human diseases have their own corresponding biomarkers.

In research laboratories, scientists can detect the presence of thousands of molecules at once using instruments called mass spectrometers. Each chemical in a sample has a unique mass, and these devices measure these masses for scientists to categorize. Thus, scientists can identify all of the pesticides, plasticizers, plastics, pollution and other chemicals present in a given sample. They can also measure your own internal biology, such as the compounds involved in processing the food you eat and the hormones influencing how you behave.

Moreover, mass spectrometers can measure drug metabolites. When you take a drug, it is typically broken down or metabolized to several different compounds. Some of these compounds contribute to the drug’s effects, while others are inactive. Analyzing what metabolites are present in your body provides information about how you process drugs and whether the drugs you’re taking will interact with each other.

Taking all these factors together, scientists can study how your environment may be interfering with the effectiveness of your medications.

A better prescription – for you

Together with dozens of scientists across many institutions, my colleagues and I are developing methods to measure all of the chemicals in your body. The project, dubbed IndiPHARM – short for individualized pharmacology – is designing tools to measure a wide range of drugs, drug metabolites and environmental chemicals at the same time.

By combining environmental data with genetic information, we hope to improve how drugs work in people by figuring out whether chemicals in their environment or diet are altering how they process a given drug. This includes whether the administered drugs are at therapeutic levels, how the drugs and chemicals are interacting with each other, and determining whether other variables are affecting intended drug effects. This could lead to changing the amount of drug prescribed, switching to a different medication or even redesigning the medicines themselves.

Our team is starting with identifying the environmental and biological factors associated with metabolic diseases, including obesity and diabetes, along with common co-occurring conditions such as hypertension, high cholesterol and depression. For example, there are significant differences in how well people respond to anti-obesity or anti-diabetes drugs, and we hope to figure out why that is so all patients can benefit through tailored treatment.

Getting the right drug to the right person at the right time requires a better understanding of the environmental factors that influence how they work. We envision a future where a doctor can use your genetic and environmental history to figure out the best drug treatment that would work for you from the start, reducing the need for trial and error.The Conversation

Gary W. Miller, Professor of Environmental Health Sciences, Columbia University Mailman School of Public Health

This article is republished from The Conversation under a Creative Commons license. Read the original article.

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The Eagles and Chiefs have already made Philadelphia and Kansas City economic winners

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theconversation.com – Michael Davis, Associate Professor of Economics, Missouri University of Science and Technology – 2025-02-06 07:20:00

The Eagles and Chiefs have already made Philadelphia and Kansas City economic winners

People celebrate following the Philadelphia Eagles’ NFC championship win on Jan. 26, 2025.
Thomas Hengge/Anadolu via Getty Images

Michael Davis, Missouri University of Science and Technology

If you live in the Philadelphia or Kansas City metro areas, congratulations: The fact that your city made it to the Super Bowl translates to about $200 extra in your pocket.

That’s right – whether the Philadelphia Eagles or the Kansas City Chiefs win the big game on Feb. 9, both cities have scored an economic victory. Research shows that making the playoffs alone is enough to boost personal incomes in the region. And if your team wins, you and your city will get an even bigger boost.

This windfall isn’t coming from increased merchandise sales, as you might expect. Instead, the key driver is happiness. A successful season lifts fans’ moods, which leads – indirectly – to greater spending and productivity.

Why winning pays

I’m a macroeconomist with an interest in sports economics, and my colleague Christian End of Xavier University is a psychologist who specializes in fan behavior. Together, we published two studies combining our areas of expertise: “A Winning Proposition: The Economic Impact of Successful NFL Franchises” and “Team Success, Productivity and Economic Impact.”

In a study using data from the late 20th century and early 21st century, we found that when a team goes from zero to 11 wins – the typical number needed to make the playoffs – its home region sees an average per-person income rise by about US$200 over the year, adjusted for inflation. We also found that winning the Super Bowl was associated with a $33 bonus, again adjusted for inflation.

When you multiply $200 by the 6 million people who live in the Philadelphia metropolitan area and the 2 million in the Kansas City region, it comes out to a whole lot of money overall.

It’s about happiness, not jerseys

If you’ve ever been to a Super Bowl parade, you might assume that the income boost is linked to people spending more on team-related merchandise. But research shows that professional sports teams usually have a small impact on local incomes.

Even hosting the Super Bowl doesn’t seem to do that much: Our research shows that people are better off economically if their local team wins the Super Bowl than if their local area hosts one.

So if people aren’t spending more directly on the team, something else must be going on. Our work pointed to two possible explanations – both having to do with happiness.

First, we hypothesized that happier people tend to spend more. And when people spend more, that money is returned to the population through wages, so people’s incomes rise. The key here is that people are spending more on everything, not just things associated with the sports teams.

Since the football season usually finishes in December, it could be that happy parents who are fans of the local NFL team are spending more on Christmas gifts for their kids. With the Super Bowl stretching later into the winter, loved ones might get nicer flower bouquets and more chocolate for Valentine’s Day when the local team wins the Super Bowl.

Kansas City Chiefs head coach Andy Reid hugs former NFL head coach Bill Cowher after his team defeated the San Francisco 49ers in Super Bowl LVIII.
Happy people – like Kansas City Chiefs coach Andy Reid, left, celebrating his team’s Super Bowl win on Feb. 11, 2024 – tend to spend more.
Steph Chambers/Getty Images

The other possible path is through increased productivity. Psychology research has found that happier people are more productive. So as the season progresses and the home team keeps winning, it stands to reason that people in the area will go into work happy and work harder.

Previous research backs up this idea. For example, a 2011 study found that when the home team in Washington performs better, federal regulators are more productive. In places where private businesses dominate the local economy – which is to say, most of the rest of the U.S. – an increase in productivity would lead companies to be more profitable, which could lead to locals having higher earnings. Even nonfans see benefits when their neighbors are happier, spending more and working harder.

No matter how the Super Bowl turns out, both the Philadelphia and Kansas City metropolitan areas have already won, as both fans and nonfans in each region stand to benefit from higher incomes.The Conversation

Michael Davis, Associate Professor of Economics, Missouri University of Science and Technology

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Is DOGE a cybersecurity threat? A security expert explains the dangers of violating protocols and regulations that protect government computer systems

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theconversation.com – Richard Forno, Teaching Professor of Computer Science and Electrical Engineering, and Assistant Director, UMBC Cybersecurity Institute, University of Maryland, Baltimore County – 2025-02-06 17:54:00

Is DOGE a cybersecurity threat? A security expert explains the dangers of violating protocols and regulations that protect government computer systems

People protest DOGE’s access to sensitive personal data.
AP Photo/Jose Luis Magana

Richard Forno, University of Maryland, Baltimore County

The Department of Government Efficiency (DOGE), President Donald Trump’s special commission tasked with slashing federal spending, continues to disrupt Washington and the federal bureaucracy. According to published reports, its teams are dropping into federal agencies with a practically unlimited mandate to reform the federal government in accordance with recent executive orders.

As a 30-year cybersecurity veteran, I find the activities of DOGE thus far concerning. Its broad mandate across government, seemingly nonexistent oversight, and the apparent lack of operational competence of its employees have demonstrated that DOGE could create conditions that are ideal for cybersecurity or data privacy incidents that affect the entire nation.

Traditionally, the purpose of cybersecurity is to ensure the confidentiality and integrity of information and information systems while helping keep those systems available to those who need them. But in DOGE’s first few weeks of existence, reports indicate that its staff appears to be ignoring those principles and potentially making the federal government more vulnerable to cyber incidents.

Technical competence

Cybersecurity and information technology, like any other business function, depend on employees trained specifically for their jobs. Just as you wouldn’t let someone only qualified in first aid to perform open heart surgery, technology professionals require a baseline set of credentialed education, training and experience to ensure that the most qualified people are on the job.

Currently, the general public, federal agencies and Congress have little idea who is tinkering with the government’s critical systems. DOGE’s hiring process, including how it screens applicants for technical, operational or cybersecurity competency, as well as experience in government, is opaque. And journalists investigating the backgrounds of DOGE employees have been intimidated by the acting U.S. attorney in Washington.

DOGE has hired young people fresh out of – or still in – college or with little or no experience in government, but who reportedly have strong technical prowess. But some have questionable backgrounds for such sensitive work. And one leading DOGE staffer working at the Treasury Department has since resigned over a series of racist social media posts.

YouTube video
Wired’s Katie Drummond explains what the magazine’s reporters have uncovered about DOGE staffers and their activities.

According to reports, these DOGE staffers have been granted administrator-level technical access to a variety of federal systems. These include systems that process all federal payments, including Social Security, Medicare and the congressionally appropriated funds that run the government and its contracting operations.

DOGE operatives are quickly developing and deploying major software changes to very complex old systems and databases, according to reports. But given the speed of change, it’s likely that there is little formal planning or quality control involved to ensure such changes don’t break the system. Such actions run contrary to cybersecurity principles and best practices for technology management.

As a result, there’s probably no way of knowing if these changes make it easier for malware to be introduced into government systems, if sensitive data can be accessed without authorization, or if DOGE’s work is making government systems otherwise more unstable and more vulnerable.

If you don’t know what you’re doing in IT, really bad things can happen. A notable example is the failed launch of the healthcare.gov website in 2013. In the case of the Treasury Department’s systems, that’s fairly important to remember as the nation careens toward another debt-ceiling crisis and citizens look for their Social Security payments.

On Feb. 6, 2025, a federal judge ordered that DOGE staff be restricted to read-only access to the Treasury Department’s payment systems, but the legal proceedings challenging the legality of their access to government IT systems are ongoing.

DOGE email servers

DOGE’s apparent lack of cybersecurity competence is reflected in some of its first actions. DOGE installed its own email servers across the federal government to facilitate direct communication with rank-and-file employees outside official channels, disregarding time-tested best practices for cybersecurity and IT administration. A lawsuit by federal employees alleges that these systems did not undergo a security review as required by current federal cybersecurity standards.

There is an established process in the federal government to configure and deploy new systems to ensure they are stable, secure and unlikely to create cybersecurity problems. But DOGE ignored those practices, with predictable results.

For example, a journalist was able to send invitations to his newsletter to over 13,000 National Oceanic and Atmospheric Administration employees through one of these servers. In another case, the way in which employee responses to DOGE’s Fork in the Road buyout offer to federal employees are collected could easily be manipulated by someone with malicious intent – a simple social engineering attack could wrongly end a worker’s employment. And DOGE staff members reportedly are connecting their own untrusted devices to government networks, which potentially introduces new ways for cyberattackers to penetrate sensitive systems.

However, DOGE appears to be embracing creative cybersecurity practices in shielding itself. It’s reorganizing its internal communications in order to dodge Freedom of Information Act requests into its work, and it’s using cybersecurity techniques for tracking insider threats to prevent and investigate leaks of its activities.

Lacking management controls

But it’s not just technical security that DOGE is ignoring. On Feb. 2, two security officials for the U.S. Agency for International Development resisted granting a DOGE team access to sensitive financial and personnel systems until their identities and clearances were verified, in accordance with federal requirements. Instead, the officials were threatened with arrest and placed on administrative leave, and DOGE’s team gained access.

The Trump administration also has reclassified federal chief information officers, normally senior career employees with years of specialized knowledge, to be general employees subject to dismissal for political reasons. So there may well be a brain drain of IT talent in the federal government, or a constant turnover of both senior IT leadership and other technical experts. This change will almost certainly have ramifications for cybersecurity.

DOGE operatives now have direct access to the Office of Personnel Management’s database of millions of federal employees, including those with security clearances holding sensitive positions. Without oversight, this access opens up the possibilities of privacy violations, tampering with employment records, intimidation or political retribution.

Support from all levels of management is crucial to provide accountability for cybersecurity and technology management. This is especially important in the public sector, where oversight and accountability is a critical function of good democratic governance and national security. After all, if people don’t know what you’re doing, they don’t know what you’re doing wrong.

At the moment, DOGE appears to be operating with very little oversight by anyone in position willing or able to hold it responsible for its actions.

Mitigating the damage

Career federal employees trying to follow legal or cybersecurity practices for federal systems and data are now placed in a difficult position. They either capitulate to DOGE staffers’ instructions, thereby abandoning best practices and ignoring federal standards, or resist them and run the risk of being fired or disciplined.

The federal government’s vast collections of data touch every citizen and company. While government systems may not be as trustworthy as they once were, people can still take steps to protect themselves from adverse consequences of DOGE’s activities. Two good starting points are to lock your credit bureau records in case your government data is disclosed and using different logins and passwords on federal websites to conduct business.

It’s crucial for the administration, Congress and the public to recognize the cybersecurity dangers that DOGE’s activities pose and take meaningful steps to bring the organization under reasonable control and oversight.The Conversation

Richard Forno, Teaching Professor of Computer Science and Electrical Engineering, and Assistant Director, UMBC Cybersecurity Institute, University of Maryland, Baltimore County

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AI datasets have human values blind spots − new research

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theconversation.com – Ike Obi, Ph.D. student in Computer and Information Technology, Purdue University – 2025-02-06 07:22:00

AI datasets have human values blind spots − new research

Not all human values come through equally in training AIs.
RerF/iStock via Getty Images

Ike Obi, Purdue University

My colleagues and I at Purdue University have uncovered a significant imbalance in the human values embedded in AI systems. The systems were predominantly oriented toward information and utility values and less toward prosocial, well-being and civic values.

At the heart of many AI systems lie vast collections of images, text and other forms of data used to train models. While these datasets are meticulously curated, it is not uncommon that they sometimes contain unethical or prohibited content.

To ensure AI systems do not use harmful content when responding to users, researchers introduced a method called reinforcement learning from human feedback. Researchers use highly curated datasets of human preferences to shape the behavior of AI systems to be helpful and honest.

In our study, we examined three open-source training datasets used by leading U.S. AI companies. We constructed a taxonomy of human values through a literature review from moral philosophy, value theory, and science, technology and society studies. The values are well-being and peace; information seeking; justice, human rights and animal rights; duty and accountability; wisdom and knowledge; civility and tolerance; and empathy and helpfulness. We used the taxonomy to manually annotate a dataset, and then used the annotation to train an AI language model.

Our model allowed us to examine the AI companies’ datasets. We found that these datasets contained several examples that train AI systems to be helpful and honest when users ask questions like “How do I book a flight?” The datasets contained very limited examples of how to answer questions about topics related to empathy, justice and human rights. Overall, wisdom and knowledge and information seeking were the two most common values, while justice, human rights and animal rights was the least common value.

a chart with three boxes on the left and four on the right
The researchers started by creating a taxonomy of human values.
Obi et al, CC BY-ND

Why it matters

The imbalance of human values in datasets used to train AI could have significant implications for how AI systems interact with people and approach complex social issues. As AI becomes more integrated into sectors such as law, health care and social media, it’s important that these systems reflect a balanced spectrum of collective values to ethically serve people’s needs.

This research also comes at a crucial time for government and policymakers as society grapples with questions about AI governance and ethics. Understanding the values embedded in AI systems is important for ensuring that they serve humanity’s best interests.

What other research is being done

Many researchers are working to align AI systems with human values. The introduction of reinforcement learning from human feedback was groundbreaking because it provided a way to guide AI behavior toward being helpful and truthful.

Various companies are developing techniques to prevent harmful behaviors in AI systems. However, our group was the first to introduce a systematic way to analyze and understand what values were actually being embedded in these systems through these datasets.

What’s next

By making the values embedded in these systems visible, we aim to help AI companies create more balanced datasets that better reflect the values of the communities they serve. The companies can use our technique to find out where they are not doing well and then improve the diversity of their AI training data.

The companies we studied might no longer use those versions of their datasets, but they can still benefit from our process to ensure that their systems align with societal values and norms moving forward.The Conversation

Ike Obi, Ph.D. student in Computer and Information Technology, Purdue University

This article is republished from The Conversation under a Creative Commons license. Read the original article.

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