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Scientists around the world report millions of new discoveries every year − but this explosive research growth wasn’t what experts predicted

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theconversation.com – David P. Baker, Professor of Sociology, Education and Demography, Penn State – 2024-10-14 07:37:00

The number of research studies published globally has risen exponentially in the past decades.

AP Photo/Frank Augstein, file

David P. Baker, Penn State and Justin J.W. Powell, University of Luxembourg

Millions of scientific papers are published globally every year. These papers in science, technology, engineering, mathematics and medicine present discoveries that range from the mundane to the profound.

Since 1900, the number of published scientific articles has doubled about every 10 to 15 years; since 1980, about 8% to 9% annually. This acceleration reflects the immense and ever-growing scope of research across countless topics, from the farthest reaches of the cosmos to the intricacies of life on Earth and human nature.

Derek de Solla Price wearing glasses and sitting in a chair with a metal device.

Derek de Solla Price wrote an influential book about the growth rate of science.

The de Solla Price family/Wikimedia Commons

Yet, this extraordinary expansion was once thought to be unsustainable. In his influential 1963 book, “Little Science, Big Science… And Beyond,” the founder of scientometrics – or data informetrics related to scientific publicationsDerek de Solla Price famously predicted limits to scientific growth.

He warned that the world would soon deplete its resources and talent pool for research. He imagined this would lead to a decline in new discoveries and potential crises in medicine, technology and the economy. At the time, scholars widely accepted his prediction of an impending slowdown in scientific progress.

Faulty predictions

In fact, science has spectacularly defied Price’s dire forecast. Instead of stagnation, the world now experiences “global mega-science” – a vast, ever-growing network of scientific discovery. This explosion of scientific production made Price’s prediction of collapse perhaps the most stunningly incorrect forecast in the study of science.

Unfortunately, Price died in 1983, too early to realize his mistake.

So, what explains the world’s sustained and dramatically increasing capacity for scientific research?

We are sociologists who study higher education and science. Our new book, “Global Mega-Science: Universities, Research Collaborations, and Knowledge Production,” published on the 60th anniversary of Price’s fateful prediction, offers explanations for this rapid and sustained scientific growth. It traces the history of scientific discovery globally.

Factors such as economic growth, warfare, space races and geopolitical competition have undoubtedly spurred research capacity. But these factors alone cannot account for the immense scale of today’s scientific enterprise.

The education revolution: Science’s secret engine

In many ways, the world’s scientific capacity has been built upon the educational aspirations of young adults pursuing higher education.

College graduates wearing graduation regalia.

Funding from higher education supports a large part of the modern scientific enterprise.

AP Photo/Paul Sancya

Over the past 125 years, increasing demand for and access to higher education has sparked a global education revolution. Now, more than two-fifths of the world’s young people ages 19-23, although with huge regional differences, are enrolled in higher education. This revolution is the engine driving scientific research capacity.

Today, more than 38,000 universities and other higher-education institutions worldwide play a crucial role in scientific discovery. The educational mission, both publicly and privately funded, subsidizes the research mission, with a big part of students’ tuition money going toward supporting faculty.

These faculty scientists balance their teaching with conducting extensive research. University-based scientists contribute 80% to 90% of the discoveries published each year in millions of papers.

External research funding is still essential for specialized equipment, supplies and additional support for research time. But the day-to-day research capacity of universities, especially academics working in teams, forms the foundation of global scientific progress.

Even the most generous national science and commercial research and development budgets cannot fully sustain the basic infrastructure and staffing needed for ongoing scientific discovery.

Likewise, government labs and independent research institutes, such as the U.S. National Institutes of Health or Germany’s Max Planck Institutes, could not replace the production capacity that universities provide.

Collaboration benefits science and society

The past few decades have also seen a surge in global scientific collaborations. These arrangements leverage diverse talent from around the world to enhance the quality of research.

International collaborations have led to millions of co-authored papers. International research partnerships were relatively rare before 1980, accounting for just over 7,000 papers, or about 2% of the global output that year. But by 2010 that number had surged to 440,000 papers, meaning 22% of the world’s scientific publications resulted from international collaborations.

This growth, building on the “collaboration dividend,” continues today and has been shown to produce the highest-impact research.

Universities tend to share academic goals with other universities and have wide networks and a culture of openness, which makes these collaborations relatively easy.

Today, universities also play a key role in international supercollaborations involving teams of hundreds or even thousands of scientists. In these huge collaborations, researchers can tackle major questions they wouldn’t be able to in smaller groups with fewer resources.

Supercollaborations have facilitated breakthroughs in understanding the intricate physics of the universe and the synthesis of evolution and genetics that scientists in a single country could never achieve alone.

The IceCube observatory, a small square building sitting on the Antarctic ice, with icons representing neutrinos showering from the sky.

The IceCube collaboration, a prime example of a global megacollaboration, has made big strides in understanding neutrinos, which are ghostly particles from space that pass through Earth.

Martin Wolf, IceCube/NSF

The role of global hubs

Hubs made up of universities from around the world have made scientific research thoroughly global. The first of these global hubs, consisting of dozens of North American research universities, began in the 1970s. They expanded to Europe in the 1980s and most recently to Southeast Asia.

These regional hubs and alliances of universities link scientists from hundreds of universities to pursue collaborative research projects.

Scientists at these universities have often transcended geopolitical boundaries, with Iranian researchers publishing papers with Americans, Germans collaborating with Russians and Ukrainians, and Chinese scientists working with their Japanese and Korean counterparts.

The COVID-19 pandemic clearly demonstrated the immense scale of international collaboration in global megascience. Within just six months of the start of the pandemic, the world’s scientists had already published 23,000 scientific studies on the virus. These studies contributed to the rapid development of effective vaccines.

With universities’ expanding global networks, the collaborations can spread through key research hubs to every part of the world.

Is global megascience sustainable?

But despite the impressive growth of scientific output, this brand of highly collaborative and transnational megascience does face challenges.

On the one hand, birthrates in many countries that produce a lot of science are declining. On the other, many youth around the world, particularly those in low-income countries, have less access to higher education, although there is some recent progress in the Global South.

Sustaining these global collaborations and this high rate of scientific output will mean expanding access to higher education. That’s because the funds from higher education subsidize research costs, and higher education trains the next generation of scientists.

De Solla Price couldn’t have predicted how integral universities would be in driving global science. For better or worse, the future of scientific production is linked to the future of these institutions.The Conversation

David P. Baker, Professor of Sociology, Education and Demography, Penn State and Justin J.W. Powell, Professor of Sociology of Education, University of Luxembourg

This article is republished from The Conversation under a Creative Commons license. Read the original article.

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The Conversation

Vitamin deficiency may be why you’re so tired – a nutritional neuroscientist explains how to kickstart your energy by getting essential nutrients in a well-rounded diet, along with more sleep and exercise

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theconversation.com – Lina Begdache, Associate Professor of Health and Wellness Studies, Binghamton University, State University of New York – 2025-01-07 07:32:00

It’s not necessarily overwork that is exhausting you.
Daniel de la Hoz/Moment via Getty Images

Lina Begdache, Binghamton University, State University of New York

Feeling drained and lethargic is common: A 2022 national survey found that 13.5% of U.S. adults said they felt “very tired” or “exhausted” most days or every day over a three-month period.

Women ages 18 to 44 had the highest rate of fatigue – just over 20%.

Being tired is linked to something deeper than just overwork or a sign of the times. I’m a registered dietitian and nutritional neuroscientist. My research, along with the work of others in the field, shows that your diet and lifestyle choices may contribute to your struggles. These two factors are closely interconnected and could be the key to understanding what’s holding you back.

In particular, not getting enough of three essential nutrients – vitamin D, vitamin B12 and omega-3 fatty acids – is linked to low energy levels.

Vitamin D

More than 40% of adult Americans are deficient in vitamin D. Low levels are linked to fatigue, bone pain, muscle weakness, mood disorders and cognitive decline.

Foods high in vitamin D include fatty fish like salmon, sardines, freshwater rainbow trout, fortified dairy products and egg yolks. Among the sources for vegetarians and vegans are fortified plant-based milks and cereals and some kinds of mushrooms.

The U.S. government’s recommended daily amount of vitamin D is 400 international units, or IU, for infants up to 12 months, 600 IU for people ages 1 to 70 and 800 IU for people over 70. Just over 5 ounces (150 grams) of sockeye salmon fillet has about 800 IU of vitamin D. If you are low in a vitamin, your doctor may prescribe you a higher dose than the recommended daily amount to elevate your blood levels to normal.

Shrimp, organ meats, milk, eggs and fortified nutritional yeast are foods high in vitamin B12.

Vitamin B12

About 20% of Americans have inadequate vitamin B12 levels, which can impair energy production and lead to anemia, resulting in fatigue.

Low levels of B12 are notably higher in older people, pregnant and lactating women, people with gastrointestinal disorders like inflammatory bowel disease, those who take certain medications like proton-pump inhibitors, and people with alcohol use disorder.

Because vitamin B12 is primarily found in meat, fish, dairy and eggs, vegetarians and vegans should consider taking a vitamin B12 supplement. The recommended daily amount for anyone ages 4 and older is 2.4 micrograms, about what’s found in 3 ounces of tuna or Atlantic salmon. Pregnant and breastfeeding women require slightly more.

Taking B12 supplements can be as effective as getting the vitamin from food – and taking the supplement with food may enhance its absorption.

That said, here’s a note on supplements in general: While they can be beneficial, they shouldn’t replace whole foods.

Not only are supplements less strictly regulated by the Food and Drug Administration compared to prescription and over-the-counter drugs, making their potency uncertain, but real food also provides a complex array of nutrients that work in a synergistic way. Many supplements on the market boast multiple servings of vegetables, but nothing beats the actual food.

A display of foods rich in omega-3 fatty acids, including salmon, avocado and a variety of nuts and seeds.
Along with salmon and sardines, the many vegan sources for omega-3 fatty acids include pecans, almonds and pumpkin seeds.
fcafotodigital/E+ via Getty Images

Omega-3 fatty acids

About 87% of adults ages 40 to 59, and about 80% of those 60 and older, don’t get enough omega-3 fatty acids to meet dietary recommendations. Neither do many pregnant women.

Omega-3 fatty acids are crucial for brain health, and a deficiency can lead to higher anxiety and depression levels and impaired cognitive function. Taken together, these deficiencies can add to fatigue.

The best sources of omega-3 fatty acids are fatty fish, but if you’re strictly vegan, flaxseeds, chia seeds and walnuts can be great alternatives. However, it’s worth noting the omega-3s in fish are absorbed better in the body than plant sources – and that determines how efficiently the body can use the omega-3.

Also, whole flaxseed has a tough outer shell, which makes it more difficult to digest and absorb its nutrients. But ground flaxseed has been broken down, making the omega-3s and other nutrients more available for absorption.

The role of alcohol

Although alcohol may provide a sense of relaxation in the moment, it actually contributes to fatigue after the buzz wears off. Alcohol is a toxin; it forces your body to prioritize its metabolism over that of nutrients, which means the body reduces the use of carbohydrates and fat for energy.

Alcohol also reduces the absorption of B vitamins, which consequently affects energy production. The bottom line: If you drink alcohol, ultimately you will feel tired.

Lifestyle factors

Diet isn’t everything. Sunlight, exercise, better sleep and stress management are all critical factors for reducing fatigue.

Your body can make vitamin D from sunlight, and you don’t need a lot. A few minutes up to a half hour of sun exposure can help most people get what they need. The amount of time can vary depending on where you live, how much clothing you wear and what time of year you get the exposure. You’ll reach your vitamin D daily quota much faster on a sunny day during the summer than a cloudy day in winter.

And it may sound counterintuitive, but the more you exercise, the more energy you will produce; working out doesn’t drain you. Instead, it boosts energy, along with mood, by improving blood flow and helping to release endorphins, which are hormones produced by the body to relieve pain or stress.

Without exercise, the human body becomes less efficient at producing energy, which leads to lethargy. Coupled with erratic blood sugar levels – often caused by diets high in refined sugars and low in nutrients – these energy dips and spikes can leave you feeling irritable and drained.

Aim for at least 150 minutes of moderate exercise each week through activities like brisk walking, cycling, swimming and strength training.

Poor sleep makes things even worse. Not getting enough rest disrupts the body’s natural recovery processes and will leave you with diminished energy and focus.

So you should try to get seven to nine hours of quality sleep each night. For some people this is not easy; creating a calming bedtime routine helps, and limiting screen time is key.

Avoid phones, computers and other screens for at least 30 to 60 minutes before bed. The blue light emitted from screens can interfere with your body’s production of melatonin, a hormone that helps regulate sleep. Conversely, activities like reading, meditation or gentle stretching help signal to your body that it’s time to sleep.

In short, there are things you can do about your fatigue. Smart choices help optimize mood, energy levels and overall health, and reduce the surges of sluggishness you feel throughout the day.

Make no mistake: Your diet and lifestyle can make all the difference between being alert or wiped out.The Conversation

Lina Begdache, Associate Professor of Health and Wellness Studies, Binghamton University, State University of New York

This article is republished from The Conversation under a Creative Commons license. Read the original article.

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Planning for spring’s garden? Bees like variety and don’t care about your neighbors’ yards

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theconversation.com – Laura Russo, Assistant Professor of Ecology and Evolutionary Biology, University of Tennessee – 2025-01-07 07:22:00

If you plant it, they will come.
Zbych/iStock via Getty Images Plus

Laura Russo, University of Tennessee

In order to reproduce, most flowering plants rely on animals to move their pollen. In turn, pollinators rely on flowers for food, including both nectar and pollen. If you’re a gardener, you might want to support this partnership by planting flowers. But if you live in an area without a lot of green space, you might wonder whether it’s worth the effort.

I study bees and other pollinators. My new research shows that bees, in particular, don’t really care about the landscape surrounding flower gardens. They seem to zero in on the particular types of flowers they like, no matter what else is around.

To design a garden that supports the greatest number and diversity of pollinators, don’t worry about what your neighbors are doing or not doing. Just focus on planting different kinds of flowers – and lots of them.

Comparing different landscapes

To test whether bees are more plentiful in natural areas, my team and I planted identical gardens – roughly 10 feet by 6½ feet (3 x 2 meters) – in five different landscapes around eastern Tennessee that ranged from cattle pastures and organic farms to a botanical garden and an arboretum. All five gardens were planted in March of 2019 and contained 18 species of native perennials from the mint, sunflower and pea families.

A young woman holding a hand held vacuum with a modified nozzle leans over a flowering plant in the midst of a larger flower garden.
Sampling bugs in one of the test gardens.
Laura Russo, CC BY-SA

Over the course of the flowering season, we surveyed pollinators by collecting the insects that landed on the flowers, so we could count and identify them. The sampling took place in a carefully standardized way. Each week we sampled every flowering plant in every garden, in every landscape, for five minutes each. We used a modified, hand-held vacuum we called the “Bug Vac” and repeated this sampling every week that flowers were in bloom for three years.

We wanted to test whether the area immediately surrounding the gardens – the floral neighborhood – made a difference in pollinator abundance, diversity and identity. So we also surveyed the area around the gardens, in a radius of about 160 feet (roughly 50 meters).

To our surprise, we found the surrounding terrain had very little influence on the abundance, diversity and composition of the pollinators coming to our test gardens. Instead, they were mostly determined by the number and type of flowers. Otherwise, pollinators were remarkably similar at all sites. A sunflower in a cattle pasture had, by and large, the same number and types of visitors as a sunflower in a botanical garden.

Menu planning for pollinators

We used native perennial plants in our study because there’s evidence they provide the best nutrition for flower-visiting insects. We chose from three plant families because each offers different nourishment.

Plants in the mint family (Lamiaceae), for example, provide a lot of sugary nectar and have easily accessible flowers that attract a wide variety of insects. I’d recommend including plants from the mint family if you want to provide a large and diverse group of insects energy for flight. If you live in Tennessee, some examples are mountain mint, wood mint and Cumberland rosemary. You can easily search for perennial plants native to your area.

A bee with bluish eyes and long antennae perches on a fushia colored flower. It is covered in tiny grains of pollen.
A long-horned bee and an ironweed plant helping each other out.
Ryan Sepsy

While some pollinators enjoy nectar, others get all their fat and protein from eating just the pollen itself. Flowers from the sunflower family (Asteraceae), including asters and coreopsis, offer large quantities of both pollen and nectar and also have very accessible flowers. Plants from this family are good for a range of pollinators, including many specialist bees, such as the blue-eyed, long-horned bee (Melissodes denticulatus), which feasts primarily on ironweed (Vernonia fasciculata), also a member of the sunflower family.

If you want to offer flowers that have the highest protein content to nourish the next generation of strong pollinators, consider plants from the pea family (Fabaceae), such as dwarf indigo, false indigo and bush clover. Some of the plants in this family do not even offer nectar as a reward. Instead, they provide high protein pollen that’s accessible only to the most effective pollinators. If you include plants from the pea family in your garden, you may observe fewer visitors, but they will be receiving pollen with high protein levels.

Selecting a few native perennials from each of these three families, all widely available in garden centers, is a good place to start. Just as a diversity of food is important for human health, a mixture of flower types offers pollinators a varied and healthy diet. Interestingly, the diversity of human diets is directly linked to pollinators, because most of the color and variety in human diets comes from plants pollinated by insects.

Plant it and they will come

Maybe you’ve heard that insects worldwide are declining in number and variety. This issue is of particular concern for humans, who rely on insects and other animals to pollinate food crops. Pollinators are indeed facing many threats, from habitat loss to pesticide exposure.

Thankfully, gardeners can provide an incredible service to these valuable animals just by planting more flowers. As our research shows, small patches of garden can help boost pollinators – even when the surrounding landscape has few resources for them. The one constant in all our research is that insects love flowers. The more flowers and the more types of flowers, the more pollinators Earth will have.The Conversation

Laura Russo, Assistant Professor of Ecology and Evolutionary Biology, University of Tennessee

This article is republished from The Conversation under a Creative Commons license. Read the original article.

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Microbes can colonize space, produce drugs and create energy − researchers are simulating their inner workings to harness how

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theconversation.com – Blaise Manga Enuh, Postdoctoral Research Associate in Microbial Genomics and Systems Biology, University of Wisconsin-Madison – 2025-01-06 07:19:00

Genome-scale metabolic models capture the complex chemical reactions that allow cells to function.
Yuri Arcurs/iStock via Getty Images Plus

Blaise Manga Enuh, University of Wisconsin-Madison

After so many years learning how microbes work, researchers are now digitally recreating their inner workings to tackle challenges ranging from climate change to space colonization.

In my work as a computational biologist, I research ways to get microbes to produce more useful chemicals, such as fuels and bioplastics, that can be used in the energy, agricultural or pharmaceutical industries. Traditionally, researchers have to conduct several trial-and-error experiments on petri dishes in order to determine the optimal conditions microbes need to produce high amounts of chemicals.

Instead, I am able to simulate these experiments all from behind a computer screen through digital blueprints that replicate the inside of microbes. Called genome-scale metabolic models, or GEMs, these virtual labs significantly reduce the time and cost required to figure out what researchers need to do to get what they’re looking for. With GEMs, researchers cannot only explore the complex network of metabolic pathways that allow living organisms to function, but also tweak, test and predict how microbes would behave in different environments, including on other planets.

As GEM technology continues to evolve, I believe these models will play an increasingly important role in shaping the future of biotechnology, medicine and space exploration.

What are genome-scale metabolic models?

Genome-scale metabolic models are digital maps of all the known chemical reactions that occur in cells – that is, the cell’s metabolism. These reactions are crucial for converting food into energy, building cellular structures and detoxifying harmful substances.

To create a GEM, I begin by analyzing an organism’s genome, which contains the genetic instructions cells use to produce proteins. A type of protein coded in the genome called enzymes are the workhorses of metabolism – they facilitate the conversion of nutrients into energy and building blocks for cells.

By linking the genes that encode enzymes to the chemical reactions they help make happen, I can build a comprehensive model that maps out the connections between genes, reactions and metabolites.

Once I build a GEM, I use some advanced computational simulations to make it work like a live cell or microbe would. One of the most common algorithms researchers use to do these simulations is called a flux balance analysis. This mathematical algorithm analyzes available data about metabolism, then makes predictions on how different chemical reactions and metabolites would act under specific conditions.

This makes GEMs particularly useful for understanding how organisms respond to genetic changes and environmental stresses. For example, I can use this method to predict how an organism will react when a specific gene is knocked out. I could also use it to predict how it might adapt to the presence of different chemicals in its environment or a lack of food.

Solving energy and climate challenges

Most of the chemicals used in agriculture, pharmaceuticals and fuels are obtained from fossil fuels. However, fossil fuels are a limited resource and significantly contribute to climate change.

Instead of extracting energy from fossil fuels, my team at the Great Lakes Bioenergy Research Center of the University of Wisconsin-Madison focuses on developing sustainable biofuels and bioproducts from plant waste. This includes cornstalk after the ears are harvested, nonedible plants such as grass, and algae. We study which crop wastes can be used for bioenergy, how to use microbes to convert them into energy, and ways to sustainably manage the land on which those crops are grown.

I am building a genome-scale metabolic model for Novosphingobium aromaticivorans, a species of bacteria that can convert very complex chemicals in plant waste to chemicals that are valuable to people, such as those used to make bioplastics, pharmaceuticals and fuels. With a clearer understanding of this conversion process, I can improve the model to more accurately simulate the conditions needed to synthesize greater amounts of these chemicals.

Researchers can then replicate these conditions in real life to generate materials that are cheaper and more accessible than those made from fossil fuels.

Bioinformatics analyzes biological data to answer questions about living organisms.

Extreme microbes and space colonization

There are microbes on Earth that can survive in extremely harsh environments. For example, Chromohalobacter canadensis can live in extremely salty conditions. Similarly, Alicyclobacillus tolerans can thrive in very acidic environments.

Since other planets typically have similarly harsh climates, these microbes may not only be able to thrive and reproduce on these planets but could potentially change the environment so humans can live there as well.

Combining GEMs with machine learning, I saw that C. canadensis and A. tolerans can undergo chemical changes that help them survive in extreme conditions. They have special proteins in their cell walls that work with enzymes to balance the chemicals in their internal environment with the chemicals in their external environment.

With GEMs, scientists can simulate the environments of other planets to study how microbes survive without necessarily needing to go to those planets themselves.

The future of GEMs

Every day, researchers are generating large amounts of data about microbial metabolism. As GEM technology advances, it opens the door to exciting new possibilities in medicine, energy, space and other areas.

Synthetic biologists can use GEMs to design entirely new organisms or metabolic pathways from scratch. This field could advance biomanufacturing by enabling the creation of organisms that efficiently produce new materials, drugs or even food.

Whole human body GEMs can also serve as an atlas for the metabolics of complex diseases. They can help map how the chemical environment of the body changes with obesity or diabetes.

Whether it’s producing biofuels or engineering new organisms, GEMs provide a powerful tool for both basic research and industrial applications. As computational biology and GEMs advance, these technologies will continue to transform how scientists understand and manipulate the metabolisms of living organisms.The Conversation

Blaise Manga Enuh, Postdoctoral Research Associate in Microbial Genomics and Systems Biology, University of Wisconsin-Madison

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