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Rain may have helped form the first cells, kick-starting life as we know it

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theconversation.com – Aman Agrawal, Postdoctoral Scholar in Chemical Engineering, University of Chicago Pritzker School of Molecular Engineering – 2024-10-15 07:28:00

How did early cells keep themselves distinct while allowing for some amount of exchange?

UChicago Pritzker School of Molecular Engineering/Peter Allen, Second Bay Studios, CC BY-ND

Aman Agrawal, University of Chicago Pritzker School of Molecular Engineering

Billions of years of evolution have made modern cells incredibly complex. Inside cells are small compartments called organelles that perform specific functions essential for the cell’s survival and operation. For instance, the nucleus stores genetic material, and mitochondria produce energy.

Another essential part of a cell is the membrane that encloses it. Proteins embedded on the surface of the membrane control the movement of substances in and out of the cell. This sophisticated membrane structure allowed for the complexity of life as we know it. But how did the earliest, simplest cells hold it all together before elaborate membrane structures evolved?

In our recently published research in the journal Science Advances, my colleagues from the University of Chicago and the University of Houston and I explored a fascinating possibility that rainwater played a crucial role in stabilizing early cells, paving the way for life’s complexity.

The origin of life

One of the most intriguing questions in science is how life began on Earth. Scientists have long wondered how nonliving matter like , gases and mineral deposits transformed into living cells capable of replication, metabolism and evolution.

Chemists Stanley Miller and Harold Urey at the University of Chicago conducted an experiment in 1953 demonstrating that complex organic compounds โ€“ meaning carbon-based molecules โ€“ could be synthesized from simpler organic and inorganic ones. Using water, methane, ammonia, hydrogen gases and electric sparks, these chemists formed amino acids.

Diagram depicting a flask of water heated and siphoned to another flask filled with gases and lightning simulating the early atmosphere, the subsequent liquid condensed and cooled in another set of tubes

The Miller-Urey experiment showed that complex organic compounds can be made from simpler organic and inorganic materials.

Yoshua Rameli Adan Perez/Wikimedia Commons, CC BY-SA

Scientists believe the earliest forms of life, called protocells, spontaneously emerged from organic molecules present on the early Earth. These primitive, cell-like structures were likely made of two fundamental components: a matrix material that provided a structural framework and a genetic material that carried instructions for protocells to function.

Over time, these protocells would have gradually evolved the ability to replicate and execute metabolic processes. Certain conditions are necessary for essential chemical reactions to occur, such as a steady energy source, organic compounds and water. The compartments formed by a matrix and a membrane crucially a stable that can concentrate reactants and protect them from the external environment, allowing the necessary chemical reactions to take place.

Thus, two crucial questions arise: What materials were the matrix and membrane of protocells made of? And how did they enable early cells to maintain the stability and function they needed to transform into the sophisticated cells that constitute all living organisms ?

Bubbles vs droplets

Scientists propose that two distinct models of protocells โ€“ vesicles and coacervates โ€“ may have played a pivotal role in the early stages of life.

Illustration of a liposome (a sphere made of two layers of a sheet of smaller spheres with dangling threads attached to form a follow center), a micelle (a sphere made of a sheet of smaller spheres), and a bilayer sheet (two layers of a sheet of smaller spheres)

Miniature compartments, such as lipid bilayers configured into capsules like liposomes and micelles, are important for cellular organization and function.

Mariana Ruiz Villarreal, LadyofHats/Wikimedia Commons

Vesicles are tiny bubbles, like soap in water. They are made of fatty molecules called lipids that naturally form thin sheets. Vesicles form when these sheets curl into a sphere that can encapsulate chemicals and safeguard crucial reactions from harsh surroundings and potential degradation.

Like miniature pockets of life, vesicles resemble the structure and function of modern cells. However, unlike the membranes of modern cells, vesicle protocells would have lacked specialized proteins that selectively allow molecules in and out of a cell and enable communication between cells. Without these proteins, vesicle protocells would have limited ability to interact effectively with their surroundings, constraining their potential for life.

Coacervates, on the other hand, are droplets formed from an accumulation of organic molecules like peptides and nucleic acids. They form when organic molecules stick together due to chemical properties that attract them to each other, such as electrostatic forces between oppositely charged molecules. These are the same forces that cause balloons to stick to hair.

One can picture coacervates as droplets of cooking oil suspended in water. Similar to oil droplets, coacervate protocells lack a membrane. Without a membrane, surrounding water can easily exchange materials with protocells. This structural feature helps coacervates concentrate chemicals and speed up chemical reactions, creating a bustling environment for the building blocks of life.

Thus, the absence of a membrane appears to make coacervates a better protocell candidate than vesicles. However, lacking a membrane also a significant drawback: the potential for genetic material to leak out.

Unstable and leaky protocells

A few years after Dutch chemists discovered coacervate droplets in 1929, Russian biochemist Alexander Oparin proposed that coacervates were the earliest model of protocells. He argued that coacervate droplets provided a primitive form of compartmentalization crucial for early metabolic processes and self-replication.

Subsequently, scientists discovered that coacervates can sometimes be composed of oppositely charged polymers: long, chainlike molecules that resemble spaghetti at the molecular scale, carrying opposite electrical charges. When polymers of opposite electrical charges are mixed, they tend to attract each other and stick together to form droplets without a membrane.

Small opaque spheres resembling droplets against a grey background

Coacervate droplets resemble oil suspended in water.

Aman Agrawal, CC BY-SA

The absence of a membrane presented a : The droplets rapidly fuse with each other, akin to individual oil droplets in water joining into a large blob. Furthermore, the lack of a membrane allowed RNA โ€“ a type of genetic material thought to be the earliest form of self-replicating molecule, crucial for the early stages of life โ€“ to rapidly exchange between protocells.

My colleague Jack Szostak showed in 2017 that rapid fusion and exchange of materials can to uncontrolled mixing of RNA, making it difficult for stable and distinct genetic sequences to evolve. This limitation suggested that coacervates might not be able to maintain the compartmentalization necessary for early life.

Compartmentalization is a strict requirement for natural selection and evolution. If coacervate protocells fused incessantly, and their genes continuously mixed and exchanged with each other, all of them would resemble each other without any genetic variation. Without genetic variation, no single protocell would have a higher probability of survival, reproduction and passing on its genes to future generations.

But life today thrives with a variety of genetic material, suggesting that nature somehow solved this problem. Thus, a solution to this problem had to exist, possibly hiding in plain sight.

Rainwater and RNA

A study I conducted in 2022 demonstrated that coacervate droplets can be stabilized and avoid fusion if immersed in deionized water โ€“ water that is free of dissolved ions and minerals. The droplets eject small ions into the water, likely allowing oppositely charged polymers on the periphery to come closer to each other and form a meshy skin layer. This meshy โ€œwallโ€ effectively hinders the fusion of droplets.

Next, with my colleagues and collaborators, Matthew Tirrell and Jack Szostak, I studied the exchange of genetic material between protocells. We placed two separate protocell populations, treated with deionized water, in test tubes. One of these populations contained RNA. When the two populations were mixed, RNA remained confined in their respective protocells for days. The meshy โ€œwallsโ€ of the protocells impeded RNA from leaking.

In contrast, when we mixed protocells that weren’t treated with deionized water, RNA diffused from one protocell to the other within seconds.

Inspired by these results, my colleague Alamgir Karim wondered if rainwater, which is a natural source of ion-free water, could have done the same thing in the prebiotic world. With another colleague, Anusha Vonteddu, I found that rainwater indeed stabilizes protocells against fusion.

Rain, we believe, may have paved the way for the first cells.

Small circles colored red, blue, or green against a black background

Droplets with meshy walls resist fusion and prevent leakage of their RNA. In this image, each color represents a different type of RNA.

Aman Agrawal, CC BY-SA

Working across disciplines

Studying the origins of life addresses both scientific curiosity about the mechanisms that led to life on Earth and philosophical questions about our place in the universe and the nature of existence.

Currently, my research delves into the very beginning of gene replication in protocells. In the absence of the modern proteins that make copies of genes inside cells, the prebiotic world would have relied on simple chemical reactions between nucleotides โ€“ the building blocks of genetic material โ€“ to make copies of RNA. Understanding how nucleotides came together to form a long chain of RNA is a crucial step in deciphering prebiotic evolution.

To address the profound question of life’s origin, it is crucial to understand the geological, chemical and environmental conditions on early Earth approximately 3.8 years ago. Thus, uncovering the beginnings of life isn’t limited to biologists. Chemical engineers like me, and researchers from various scientific fields, are exploring this captivating existential question.The Conversation

Aman Agrawal, Postdoctoral Scholar in Chemical Engineering, University of Chicago Pritzker School of Molecular Engineering

This article is republished from The Conversation under a Creative Commons license. Read the original article.

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Scientists around the world report millions of new discoveries every year โˆ’ but this explosive research growth wasnโ€™t what experts predicted

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theconversation.com – David P. Baker, Professor of Sociology, Education and Demography, Penn – 2024-10-14 07:37:00

The number of research studies published globally has risen exponentially in the past decades.

AP Photo/Frank Augstein, file

David P. Baker, Penn State and Justin J.W. Powell, University of Luxembourg

Millions of scientific papers are published globally every year. These papers in science, technology, engineering, mathematics and medicine present discoveries that range from the mundane to the profound.

Since 1900, the number of published scientific articles has doubled about every 10 to 15 years; since 1980, about 8% to 9% annually. This acceleration reflects the immense and ever-growing scope of research across countless topics, from the farthest reaches of the cosmos to the intricacies of life on Earth and human nature.

Derek de Solla Price wearing glasses and sitting in a chair with a metal device.

Derek de Solla Price wrote an influential book about the growth rate of science.

The de Solla Price family/Wikimedia Commons

Yet, this extraordinary expansion was once thought to be unsustainable. In his influential 1963 book, โ€œLittle Science, Big Scienceโ€ฆ And Beyond,โ€ the founder of scientometrics โ€“ or data informetrics related to scientific publications โ€“ Derek de Solla Price famously predicted limits to scientific growth.

He warned that the world would soon deplete its resources and talent pool for research. He imagined this would lead to a decline in new discoveries and potential crises in medicine, technology and the economy. At the time, scholars widely accepted his prediction of an impending slowdown in scientific progress.

Faulty predictions

In fact, science has spectacularly defied Price’s dire forecast. Instead of stagnation, the world now experiences โ€œglobal mega-scienceโ€ โ€“ a vast, ever-growing network of scientific discovery. This explosion of scientific production made Price’s prediction of collapse perhaps the most stunningly incorrect forecast in the study of science.

Unfortunately, Price died in 1983, too early to realize his mistake.

So, what explains the world’s sustained and dramatically increasing capacity for scientific research?

We are sociologists who study higher education and science. Our new book, โ€œGlobal Mega-Science: Universities, Research Collaborations, and Knowledge Production,โ€ published on the 60th anniversary of Price’s fateful prediction, offers explanations for this rapid and sustained scientific growth. It traces the history of scientific discovery globally.

Factors such as economic growth, warfare, races and geopolitical competition have undoubtedly spurred research capacity. But these factors alone cannot account for the immense scale of ‘s scientific enterprise.

The education revolution: Science’s secret engine

In many ways, the world’s scientific capacity has been built upon the educational aspirations of young adults pursuing higher education.

College graduates wearing graduation regalia.

from higher education supports a large part of the modern scientific enterprise.

AP Photo/Paul Sancya

Over the past 125 years, increasing demand for and access to higher education has sparked a global education revolution. Now, more than two-fifths of the world’s young people ages 19-23, although with huge regional differences, are enrolled in higher education. This revolution is the engine driving scientific research capacity.

Today, more than 38,000 universities and other higher-education institutions worldwide play a crucial role in scientific discovery. The educational mission, both publicly and privately funded, subsidizes the research mission, with a big part of ‘ tuition money going toward supporting faculty.

These faculty scientists balance their teaching with conducting extensive research. University-based scientists contribute 80% to 90% of the discoveries published each year in millions of papers.

External research funding is still essential for specialized equipment, supplies and additional for research time. But the day-to-day research capacity of universities, especially academics working in teams, forms the foundation of global scientific progress.

Even the most generous national science and commercial research and development budgets cannot fully sustain the basic and staffing needed for ongoing scientific discovery.

Likewise, labs and independent research institutes, such as the U.S. National Institutes of Health or Germany’s Max Planck Institutes, could not replace the production capacity that universities provide.

Collaboration benefits science and society

The past few decades have also seen a surge in global scientific collaborations. These arrangements leverage diverse talent from around the world to enhance the quality of research.

International collaborations have led to millions of co-authored papers. International research partnerships were relatively rare before 1980, accounting for just over 7,000 papers, or about 2% of the global output that year. But by 2010 that number had surged to 440,000 papers, meaning 22% of the world’s scientific publications resulted from international collaborations.

This growth, building on the โ€œcollaboration dividend,โ€ continues today and has been shown to produce the highest-impact research.

Universities tend to share academic goals with other universities and have wide networks and a culture of openness, which makes these collaborations relatively easy.

Today, universities also play a key role in international supercollaborations involving teams of hundreds or even thousands of scientists. In these huge collaborations, researchers can tackle major questions they wouldn’t be able to in smaller groups with fewer resources.

Supercollaborations have facilitated breakthroughs in understanding the intricate physics of the universe and the synthesis of evolution and genetics that scientists in a single country could never achieve alone.

The IceCube observatory, a small square building sitting on the Antarctic ice, with icons representing neutrinos showering from the sky.

The IceCube collaboration, a prime example of a global megacollaboration, has made big strides in understanding neutrinos, which are ghostly particles from space that pass through Earth.

Martin Wolf, IceCube/NSF

The role of global hubs

Hubs made up of universities from around the world have made scientific research thoroughly global. The first of these global hubs, consisting of dozens of North American research universities, began in the 1970s. They expanded to Europe in the 1980s and most recently to Southeast Asia.

These regional hubs and alliances of universities link scientists from hundreds of universities to pursue collaborative research projects.

Scientists at these universities have often transcended geopolitical boundaries, with Iranian researchers publishing papers with Americans, Germans collaborating with Russians and Ukrainians, and Chinese scientists working with their Japanese and Korean counterparts.

The pandemic clearly demonstrated the immense scale of international collaboration in global megascience. Within just six months of the start of the pandemic, the world’s scientists had already published 23,000 scientific studies on the virus. These studies contributed to the rapid development of effective vaccines.

With universities’ expanding global networks, the collaborations can spread through key research hubs to every part of the world.

Is global megascience sustainable?

But despite the impressive growth of scientific output, this brand of highly collaborative and transnational megascience does face challenges.

On the one hand, birthrates in many countries that produce a lot of science are declining. On the other, many youth around the world, particularly those in low-income countries, have less access to higher education, although there is some recent progress in the Global South.

Sustaining these global collaborations and this high rate of scientific output will mean expanding access to higher education. That’s because the funds from higher education subsidize research costs, and higher education trains the next generation of scientists.

De Solla Price couldn’t have predicted how integral universities would be in driving global science. For better or worse, the future of scientific production is linked to the future of these institutions.The Conversation

David P. Baker, Professor of Sociology, Education and Demography, Penn State and Justin J.W. Powell, Professor of Sociology of Education, University of Luxembourg

This article is republished from The Conversation under a Creative Commons license. Read the original article.

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Comet Tsuchinshan-ATLAS is a Halloween visitor from the spooky Oort Cloud โˆ’ the invisible bubble thatโ€™s home to countless space objects

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theconversation.com – James Wray, Professor of Earth and Atmospheric Sciences, Georgia Institute of Technology – 2024-10-11 12:36:00

The human mind may find it difficult to conceptualize: a cosmic cloud so colossal it surrounds the Sun and eight planets as it extends trillions of miles into deep .

The spherical shell known as the Oort Cloud is, for all practical purposes, invisible. Its constituent particles are spread so thinly, and so far from the light of any star, the Sun, that astronomers simply cannot see the cloud, even though it envelops us like a blanket.

It is also theoretical. Astronomers infer the Oort Cloud is there because it’s the only logical explanation for the arrival of a certain class of comets that sporadically visit our solar system. The cloud, it turns out, is basically a gigantic reservoir that may hold billions of icy celestial bodies.

Two of those bodies will pass by Earth in the days leading up to Halloween. Tsuchinshan-ATLAS, also known as Comet C/2023 A3, will be at its brightest, and likely visible to the naked eye, for a or two after Oct. 12, the day it’s closest to Earth โ€“ just look to the western sky shortly after sunset. As the days pass, the comet will get fainter and move to a higher part of the sky.

A view of comet Tsuchinshan-ATLAS from the International Space Station.

The second comet, C/2024 S1 (ATLAS), just discovered on Sept. 27, should be visible around the end of October. The comet will pass closest to Earth on Oct. 24 โ€“ look low in the eastern sky just before sunrise. Then, after swinging around the Sun, the comet may reappear in the western night sky right around Halloween. It’s possible, however, that it could disintegrate, in part or in whole, as sometimes happens when comets pass by the Sun โ€“ and this one will come within 1 million miles (1.6 million kilometers) of our star.

As a planetary astronomer, I’m particularly curious about the Oort Cloud and the icy bodies inhabiting it. The Cloud’s may be a reason why ignited on Earth; crashing on our planet eons ago, these ice bodies may have supplied at least some of the water that all life requires. At the same time, these same objects pose an ever-present threat to Earth’s continuation โ€“ and our survival.

Billions of comets

If an Oort Cloud object finds its way to the inner solar system, its ices vaporize. That produces a tail of debris that becomes visible as a comet.

Some of these bodies, known as long-period comets, have orbits of hundreds, thousands or even millions of years, like Tsuchinshan-ATLAS. This is unlike the so-called short-period comets, which do not visit the Oort Cloud and have comparatively quick orbits. Halley’s comet, which cuts a path through the solar system and orbits the Sun every 76 years or so, is one of them.

The 20th-century Dutch astronomer Jan Oort, intrigued by the long-period comets, wrote a paper on them in 1950. He noted about 20 of the comets had an average distance from the Sun that was more than 10,000 astronomical units. This was astounding; just one AU is the distance of the Earth from the Sun, which is about 93 million miles. Multiply 93 million by 10,000, and you’ll find these comets come from over a trillion miles away. What’s more, Oort suggested, they were not necessarily the cloud’s outermost objects.

Nearly 75 years after Oort’s paper, astronomers still can’t directly image this part of space. But they do estimate the Oort Cloud spans up to 10 trillion miles from the Sun, which is almost halfway to Proxima Centauri, the next closest star.

The long-period comets spend most of their time at those vast distances, making only brief and rapid visits close to the Sun as they come in from all directions. Oort speculated the cloud contained 100 of these icy objects. That may be as numerous as the number of stars in our galaxy.

How did they get there? Oort suggested, and modern simulations have confirmed, that these icy bodies could have initially formed near Jupiter, the solar system’s largest planet. Perhaps these objects had their orbits around the Sun disturbed by Jupiter โ€“ similar to how NASA spacecraft bound for destinations from Saturn to Pluto have typically swung by the giant planet to accelerate their journeys outward.

Some of these objects would have escaped the solar system permanently, becoming interstellar objects. But others would have ended up with orbits like those of the long-period comets.

An artistic illustration of the solar system and the Oort Cloud.

An illustration of the solar system and the Oort Cloud. The numbers on the graph depict AUs, or astronomical units. Note the location of Voyager 2, which will take another 30,000 years to fly out of the Cloud.
NASA

Threats to Earth

Long-period comets present a particular potential danger to Earth. Because they are so far from our Sun, their orbits are readily altered by the gravity of other . That means scientists have no idea when or where one will appear, until it does, suddenly. By then, it’s typically closer than Jupiter and moving rapidly, at tens of thousands of miles per hour. Indeed, the fictional comet that doomed Earth in the film โ€œDon’t Look Upโ€ came from the Oort Cloud.

New Oort Cloud comets are discovered all the time, a dozen or so per year in recent years. The odds of any of them colliding with Earth are extremely low. But it is possible. The recent of NASA’s DART mission, which altered the orbit of a small asteroid, demonstrates one plausible approach to fending off these small bodies. But that mission was developed after years of studying its target. A comet from the Oort Cloud may not offer that much time โ€“ maybe just months, weeks or even days.

Or no time at all. ‘Oumuamua, the odd little object that visited our solar system in 2017, was discovered not before but after its closest approach to Earth. Although ‘Oumuamua is an interstellar object, and not from the Oort Cloud, the proposition still applies; one of these objects could sneak up on us, and the Earth would be defenseless.

One way to prepare for these objects is to better understand their basic properties, including their size and composition. Toward this end, my colleagues and I work to characterize new long-period comets. The largest known one, Bernardinelliโ€“Bernstein, discovered just three years ago, is roughly 75 miles (120 kilometers) across. Most known comets are much smaller, from one to a few miles, and some smaller ones are too faint for us to see. But newer telescopes are helping. In particular, the Rubin Observatory’s decade-long Legacy Survey of Space and Time, starting up in 2025, may double the list of known Oort Cloud comets, which now stands at about 4,500.

The unpredictability of these objects makes them a challenging target for spacecraft, but the European Space Agency is preparing a mission to do just that: Comet Interceptor. With a launch planned for 2029, the probe will park in space until a suitable target from the Oort Cloud appears. Studying one of these ancient and pristine objects could offer scientists clues about the origins of the solar system.

As for the comets now in Earth’s vicinity, it’s OK to look up. Unlike the comet in the DiCaprio , these two will not crash into the Earth. The nearest Tsuchinshan-ATLAS will get to us is about 44 million miles (70 million kilometers); C/2024 S1 (ATLAS), about 80 million miles (130 million kilometers). Sounds like a long way, but in space, that’s a near miss.

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Happiness class is helping clinically depressed school teachers become emotionally healthy โˆ’ with a cheery assist from Aristotle

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theconversation.com – John Sommers-Flanagan, Clinical Psychologist and Professor of Counseling, University of Montana – 2024-10-11 07:32:00

Text saying: Uncommon Courses, from The Conversation

Uncommon Courses is an occasional from U.S. highlighting unconventional approaches to teaching.

Title of Course

Evidence-Based Happiness for Teachers

What prompted the idea for the course?

I was discouraged. For nearly three decades, as a clinical psychologist, I trained mental health professionals on suicide assessment. The work was good but difficult.

All the while, I watched in dismay as U.S. suicide rates relentlessly increased for 20 consecutive years, from 1999 to 2018, followed by a slight dip during the pandemic, and then a rise in 2021 and 2022 โ€“ this despite more local, and national suicide prevention programming than ever.

I consulted my wife, Rita, who also happens to be my favorite clinical psychologist. We decided to explore the science of happiness. Together, we established the Montana Happiness Project and began offering evidence-based happiness workshops to complement our suicide prevention work.

In 2021, the Arthur M. Blank Family Foundation, through the University of Montana, awarded us a US$150,000 grant to the state’s K-12 public school teachers, counselors and staff. We’re using the funds to offer these educators low-cost, online graduate courses on happiness. In spring 2023, the foundation awarded us another $150,000 so we could extend the program through December 2025.

What does the course explore?

Using the word โ€œhappinessโ€ can be off-putting. Sometimes, people associate happiness with recommendations to just smile, cheer up and suppress negative emotions โ€“ which can lead to toxic positivity.

As mental health professionals, my wife and I reject that definition. Instead, we embrace Aristotle’s concept of โ€œeudaimonic happinessโ€: the daily pursuit of meaning, mutually supportive relationships and becoming the best possible version of yourself.

The heart of the course is an academic, personal and experiential exploration of evidence-based positive psychology interventions. These are intentional practices that can improve mood, optimism, relationships and physical wellness and offer a sense of purpose. Examples include gratitude, acts of kindness, savoring, mindfulness, mood music, practicing forgiveness and journaling about your best possible future self.

are required to implement at least 10 of 14 positive psychology interventions, and then to talk and write about their experiences on implementing them.

Why is this course relevant now?

Teachers are more distressed than ever before. They’re anxious, depressed and discouraged in ways that adversely affect their ability to teach effectively, which is one reason why so many of them leave the profession after a short period of time. It’s not just the low pay โ€“ educators need support, appreciation and coping tools; they also need to know they’re not alone.

This exercise helps you focus on what goes right, rather than the things that go wrong.

What’s a critical lesson from the course?

The lesson on sleep is especially powerful for educators. A of 33 studies from 15 countries reported that 36% to 61% of K-12 teachers suffered from insomnia. Although the rates varied across studies, sleep problems were generally worse when teachers were exposed to classroom violence, had low job satisfaction and were experiencing depressive symptoms.

The sleep lesson includes, along with sleep hygiene strategies, a happiness practice and insomnia intervention called Three Good Things, developed by the renowned positive psychologist Martin Seligman.

I describe the technique, in Seligman’s words: โ€œWrite down, for one , before you go to sleep, three things that went well for you during the day, and then reflect on why they went well.โ€

Next, I make light of the concept: โ€œI’ve always thought Three Good Things was hokey, simplistic and silly.โ€ I show a video of Seligman saying, โ€œI don’t need to recommend beyond a week, typically โ€ฆ because when you do this, you find you like it so much, most people just keep doing it.โ€ At that point, I roll my eyes and say, โ€œMaybe.โ€

Then I share that I often awakened for years at 4 a.m. with terribly dark . Then โ€“ funny thing โ€“ I tried using Three Good Things in the middle of the night. It wasn’t a perfect solution, but it was a vast improvement over lying helplessly in bed while negative thoughts pummeled me.

The Three Good Things lesson is emblematic of how we encourage teachers in our course โ€“ using science, playful cynicism and an open and experimental mindset to apply the evidence-based happiness practices in ways that work for them.

I also encourage students to understand that the strategies I offer are not universally effective. What works for others may not work for them, which is why they should experiment with many different approaches.

What will the course prepare students to do?

The educators leave the course with a written lesson plan they can implement at their school, if they wish. As they deepen their happiness practice, they can also share it with other teachers, their students and their families.

Over the past 16 months, we’ve taught this course to 156 K-12 educators and other school personnel. In a not-yet-published survey that we carried out, more than 30% of the participants scored as clinically depressed prior to starting the class, compared with just under 13% immediately after the class.

This improvement is similar to the results obtained by antidepressant medications and psychotherapy.

The educators also reported overall better health after taking the class. Along with improved sleep, they took fewer sick days, experienced fewer headaches and reported reductions in cold, flu and stomach symptoms.

As resources allow, we plan to tailor these courses to other people with high-stress jobs. Already, we are receiving requests from police officers, providers, veterinarians and construction workers.

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