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NIH funding cuts will hit red states, rural areas and underserved communities the hardest

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theconversation.com – Prakash Nagarkatti, Professor of Pathology, Microbiology and Immunology, University of South Carolina – 2025-03-07 07:26:00

Protesters on the University of Illinois Chicago campus raise concerns over funding cuts for medical research on Feb. 19, 2025.
Scott Olson via Getty Images

Prakash Nagarkatti, University of South Carolina and Mitzi Nagarkatti, University of South Carolina

The National Institutes of Health is the largest federal funder of medical research in the U.S. NIH funds drive research and innovation, leading to better understanding and treatment of diseases and improved health outcomes.

The NIH provided more than US$35 billion in grants to over 2,500 universities and other institutions in 2023 to support biomedical research. Thus, it came as a shock to these institutions when the NIH, based on a new Trump administration policy, announced on Feb. 7, 2025, that it intends to cut the funding used to support the grantee institutions by $5.5 billion annually.

On March 5, a U.S. district judge in Boston issued a nationwide injunction blocking the administration from implementing the proposed cuts to NIH funding, arguing that the planned cuts were unlawful. However, the White House will almost certainly appeal.

We are a husband-and-wife team of immunologists who have been funded by the NIH for several decades. We believe our research has led to a better understanding of inflammatory and autoimmune diseases. In addition, one of us (Prakash Nagarkatti) served as vice president for research at the University of South Carolina for over a decade, managing all NIH grants awarded to the university.

While we believe such cuts will be detrimental to the entire country, they will disproportionately hurt states that traditionally have received very low levels of NIH funding, the majority of which are red states that supported Trump’s election to a second term. This is because such states lack resources to develop advanced research infrastructure necessary to compete nationally for NIH funding.

Several Republican senators have vocally opposed the funding cuts, including Susan Collins of Maine, who said they “would be devastating, stopping vital biomedical research and leading to the loss of jobs.”

Support for cancer, Alzheimer’s research

NIH funding is crucial for advancing biomedical research, improving public health and fostering innovation. It has a broad impact on different facets of society.

The agency funds biomedical research leading to the development of vaccines or new drugs to prevent and treat infectious diseases and clinical disorders. The NIH played a crucial role in funding research on pandemics and global health crises caused by HIV/AIDS and COVID-19.

In addition, the NIH supports advanced research in focused areas such as cancer, through the establishment of designated centers that offer cancer prevention, diagnosis, clinical trials and advanced treatment. Each year, approximately 400,000 patients receive cancer diagnoses and treatment at such centers.

Similarly, the NIH supports research in other focused areas, such as Alzheimer’s disease, through the establishment of specialized research centers.

The NIH also supports Small Business Innovation Research and Small Business Technology Transfer opportunities. These programs stimulate technological innovation by funding small businesses to commercialize new research ideas.

Moreover, the agency provides funding to train the next generation of biomedical scientists, clinicians and public health professionals. Thus, the NIH awards create jobs at universities, biotechnology companies and related industries. Together, such NIH programs promote local and national economies.

In 2024, NIH funding generated an estimated US$92 billion in economic activity. Every $100 million in NIH funding generates 76 patents, which creates $598 million in further research and development, as reported by NIH.

Therefore, any cuts to the agency’s budget will have far-reaching and significant consequences on health outcomes and the economy.

YouTube video
How the NIH funding process works – and how the cuts will affect research.

Caps on indirect costs

When the NIH awards grants, it is divided into two separate categories: the direct costs, which include expenses that are necessary to pursue the proposed work and that are provided to the scientists, and the indirect costs. These cover expenses such as maintenance of lab space, utilities, grant management, federal regulatory compliance, security and other miscellaneous needs. These funds are provided directly to the institution.

Indirect costs are negotiated between the institution and the federal agency and expressed as a percentage of the direct costs. Because each institution has unique operational expenses, the indirect cost rates vary from 30% to 70%.

The new policy rolled out by the NIH capped the indirect costs for all institutions at a fixed rate of 15%. In 2023, NIH spent $35 billion to support research at various institutions, of which $9 billion was used to cover indirect costs. Thus, NIH estimates it could save $4 billion by capping indirect costs at 15%.

A researcher in a white lab coat peers through a microscope.
Inside an NIH lab in Bethesda, Md., where researchers work on treatments and cures for disease, including cancer.
Saul Loeb/AFP via Getty Images

How red states get hurt the most

There is a significant geographic disparity in NIH funding that most people are unaware of. There are 27 states in the U.S. that receive 94% of NIH funding, while the other 23 states receive only 6%. Moreover, the NIH funding received by the 23 states has remained relatively unchanged for the past 20  years.

There are many reasons why the latter states are less competitive. These include: lack of large medical centers, hospitals and research-intensive universities; thin and more rural populations; less robust economies; and lack of cutting-edge research infrastructure driven by less investment by the states in research and development.

It is for these reasons that Congress in 1993 authorized the NIH to start a new program called the Institutional Development Award, or IDeA, to support the 23 states plus Puerto Rico that have traditionally received low levels of NIH funding. Such states are commonly called IDeA states and contain predominantly rural and medically underserved communities.

These awards, which constitute less than 1% of the total NIH budget, are expected to help these states grow their research infrastructure and make them more competitive nationally.

The IDeA states are: Alaska, Arkansas, Delaware, Hawaii, Idaho, Kansas, Kentucky, Louisiana, Maine, Mississippi, Montana, Nebraska, Nevada, New Hampshire, New Mexico, North Dakota, Oklahoma, Rhode Island, South Carolina, South Dakota, Vermont, West Virginia, and Wyoming, plus Puerto Rico. All the states but Delaware, Hawaii, Maine, New Hampshire, New Mexico, Rhode Island and Vermont voted for Trump in the 2024 election.

Indirect costs pay for cutting-edge technologies

Indirect costs, in addition to supporting the management of specific grants, are also helpful in promoting the institutions’ research infrastructure.

The indirect costs help purchase and upgrade state-of-the-art research equipment and technologies. They help institutions develop high-performance computing facilities that are critical for research missions and provide access to journals and books through the library facilities. These costs also renovate old labs and help create new cutting-edge facilities such as germ-free facilities for microbiome research.

Thus, the indirect costs are critical for IDeA states that have limited resources such as state support for pursuing research.

According to the Higher Education Research and Development Survey, in 2023, non-IDeA states like California invested $548 million and New York over $303 million in R&D. In contrast, IDeA states Kentucky and West Virginia invested $49 million and $15 million, respectively, in R&D.

Such data clearly demonstrates how challenging it would be for IDeA states to face cuts in NIH funding and advance research infrastructure.

In our view, it is critical that all states have access to NIH research funding to enable the states to solve the unique challenges they face, such as environmental issues and population health disparities.

For example, biomedical scientists and clinicians trained by NIH grants are addressing locally relevant issues such as coal workers’ pneumoconiosis, commonly known as black lung disease, which occurs when coal dust is inhaled. This is an occupational hazard linked to the coal industry in West Virginia and Kentucky.

Similarly, Hawaii, with its tropical climate, has mosquitoes that can carry dengue virus, so dengue infection can pose a unique health and economic problem for this state when compared with the others in the U.S.

Training the biomedical workforce and physicians in IDeA states also helps with retaining health providers in the state to further address these local challenges and prevents brain-drain to other non-IDeA states.

IDeA states heavily rely on NIH funds to pursue and advance their research capabilities and address local and general health challenges. For such states, already struggling to receive NIH funding, reducing indirect costs would further exacerbate their disadvantages, increasing the risk of falling behind in medical research, patient care and regional economic growth.The Conversation

Prakash Nagarkatti, Professor of Pathology, Microbiology and Immunology, University of South Carolina and Mitzi Nagarkatti, Professor of Pathology, Microbiology and Immunology, University of South Carolina

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The Conversation

Are twins allergic to the same things?

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theconversation.com – Breanne Hayes Haney, Allergy and Immunology Fellow-in-Training, School of Medicine, West Virginia University – 2025-04-14 07:42:00

If one has a reaction to a new food, is the other more likely to as well?
BjelicaS/iStock via Getty Images Plus

Breanne Hayes Haney, West Virginia University

Curious Kids is a series for children of all ages. If you have a question you’d like an expert to answer, send it to curiouskidsus@theconversation.com.


Are twins allergic to the same things? – Ella, age 7, Philadelphia


Allergies, whether spring sneezes due to pollen or trouble breathing triggered by a certain food, are caused by a combination of someone’s genes and the environment they live in.

The more things two people share, the higher their chances of being allergic to the same things. Twins are more likely to share allergies because of everything they have in common, but the story doesn’t end there.

I’m an allergist and immunologist, and part of my job is treating patients who have environmental, food or drug allergies. Allergies are really complex, and a lot of factors play a role in who gets them and who doesn’t.

What is an allergy?

Your immune system makes defense proteins called antibodies. Their job is to keep watch and attack any invading germs or other dangerous substances that get inside your body before they can make you sick.

An allergy happens when your body mistakes some usually harmless substance for a harmful intruder. These trigger molecules are called allergens.

diagram of Y-shaped antibodies sticking to other molecules
Y-shaped antibodies are meant to grab onto any harmful germs, but sometimes they make a mistake and grab something that isn’t actually a threat: an allergen.
ttsz/iStock via Getty Images Plus

The antibodies stick like suction cups to the allergens, setting off an immune system reaction. That process leads to common allergy symptoms: sneezing, a runny or stuffy nose, itchy, watery eyes, a cough. These symptoms can be annoying but minor.

Allergies can also cause a life-threatening reaction called anaphylaxis that requires immediate medical attention. For example, if someone ate a food they were allergic to, and then had throat swelling and a rash, that would be considered anaphylaxis.

The traditional treatment for anaphylaxis is a shot of the hormone epinephrine into the leg muscle. Allergy sufferers can also carry an auto-injector to give themselves an emergency shot in case of a life-threatening case of anaphylaxis. An epinephrine nasal spray is now available, too, which also works very quickly.

A person can be allergic to things outdoors, like grass or tree pollen and bee stings, or indoors, like pets and tiny bugs called dust mites that hang out in carpets and mattresses.

A person can also be allergic to foods. Food allergies affect 4% to 5% of the population. The most common are to cow’s milk, eggs, wheat, soy, peanuts, tree nuts, fish, shellfish and sesame. Sometimes people grow out of allergies, and sometimes they are lifelong.

Who gets allergies?

Each antibody has a specific target, which is why some people may only be allergic to one thing.

The antibodies responsible for allergies also take care of cleaning up any parasites that your body encounters. Thanks to modern medicine, people in the United States rarely deal with parasites. Those antibodies are still ready to fight, though, and sometimes they misfire at silly things, like pollen or food.

Hygiene and the environment around you can also play a role in how likely it is you’ll develop allergies. Basically, the more different kinds of bacteria that you’re exposed to earlier in life, the less likely you are to develop allergies. Studies have even shown that kids who grow up on farms, kids who have pets before the age of 5, and kids who have a lot of siblings are less likely to develop allergies. Being breastfed as a baby can also protect against having allergies.

Children who grow up in cities are more likely to develop allergies, probably due to air pollution, as are children who are around people who smoke.

Kids are less likely to develop food allergies if they try foods early in life rather than waiting until they are older. Sometimes a certain job can contribute to an adult developing environmental allergies. For example, hairdressers, bakers and car mechanics can develop allergies due to chemicals they work with.

Genetics can also play a huge role in why some people develop allergies. If a mom or dad has environmental or food allergies, their child is more likely to have allergies. Specifically for peanut allergies, if your parent or sibling is allergic to peanuts, you are seven times more likely to be allergic to peanuts!

two boys in identical shirts side by side look at each other
Do you have an allergy twin in your family?
Ronnie Kaufman/DigitalVision via Getty Images Plus

Identical in allergies?

Back to the idea of twins: Yes, they can be allergic to the same things, but not always.

Researchers in Australia found that 60% to 70% of twins in one study both had environmental allergies, and identical twins were more likely to share allergies than fraternal (nonidentical) twins. Identical twins share 100% of their genes, while fraternal twins only share about 50% of their genes, the same as any pair of siblings.

A lot more research has been done on the genetics of food allergies. One peanut allergy study found that identical twins were more likely to both be allergic to peanuts than fraternal twins were.

So, twins can be allergic to the same things, and it’s more likely that they will be, based on their shared genetics and growing up together. But twins aren’t automatically allergic to the exact same things.

Imagine if two twins are separated at birth and raised in different homes: one on a farm with pets and one in the inner city. What if one’s parents smoke, and the others don’t? What if one lives with a lot of siblings and the other is an only child? They certainly could develop different allergies, or maybe not develop allergies at all.

Scientists like me are continuing to research allergies, and we hope to have more answers in the future.


Hello, curious kids! Do you have a question you’d like an expert to answer? Ask an adult to send your question to CuriousKidsUS@theconversation.com. Please tell us your name, age and the city where you live.

And since curiosity has no age limit – adults, let us know what you’re wondering, too. We won’t be able to answer every question, but we will do our best.The Conversation

Breanne Hayes Haney, Allergy and Immunology Fellow-in-Training, School of Medicine, West Virginia University

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AI-generated images can exploit how your mind works − here’s why they fool you and how to spot them

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theconversation.com – Arryn Robbins, Assistant Professor of Psychology, University of Richmond – 2025-04-11 07:43:00

A beautiful kitchen to scroll past – but check out the clock.
Tiny Homes via Facebook

Arryn Robbins, University of Richmond

I’m more of a scroller than a poster on social media. Like many people, I wind down at the end of the day with a scroll binge, taking in videos of Italian grandmothers making pasta or baby pygmy hippos frolicking.

For a while, my feed was filled with immaculately designed tiny homes, fueling my desire for minimalist paradise. Then, I started seeing AI-generated images; many contained obvious errors such as staircases to nowhere or sinks within sinks. Yet, commenters rarely pointed them out, instead admiring the aesthetic.

These images were clearly AI-generated and didn’t depict reality. Did people just not notice? Not care?

As a cognitive psychologist, I’d guess “yes” and “yes.” My expertise is in how people process and use visual information. I primarily investigate how people look for objects and information visually, from the mundane searches of daily life, such as trying to find a dropped earring, to more critical searches, like those conducted by radiologists or search-and-rescue teams.

With my understanding of how people process images and notice − or don’t notice − detail, it’s not surprising to me that people aren’t tuning in to the fact that many images are AI-generated.

We’ve been here before

The struggle to detect AI-generated images mirrors past detection challenges such as spotting photoshopped images or computer-generated images in movies.

But there’s a key difference: Photo editing and CGI require intentional design by artists, while AI images are generated by algorithms trained on datasets, often without human oversight. The lack of oversight can lead to imperfections or inconsistencies that can feel unnatural, such as the unrealistic physics or lack of consistency between frames that characterize what’s sometimes called “AI slop.”

Despite these differences, studies show people struggle to distinguish real images from synthetic ones, regardless of origin. Even when explicitly asked to identify images as real, synthetic or AI-generated, accuracy hovers near the level of chance, meaning people did only a little better than if they’d just guessed.

In everyday interactions, where you aren’t actively scrutinizing images, your ability to detect synthetic content might even be weaker.

Attention shapes what you see, what you miss

Spotting errors in AI images requires noticing small details, but the human visual system isn’t wired for that when you’re casually scrolling. Instead, while online, people take in the gist of what they’re viewing and can overlook subtle inconsistencies.

Visual attention operates like a zoom lens: You scan broadly to get an overview of your environment or phone screen, but fine details require focused effort. Human perceptual systems evolved to quickly assess environments for any threats to survival, with sensitivity to sudden changes − such as a quick-moving predator − sacrificing precision for speed of detection.

This speed-accuracy trade-off allows for rapid, efficient processing, which helped early humans survive in natural settings. But it’s a mismatch with modern tasks such as scrolling through devices, where small mistakes or unusual details in AI-generated images can easily go unnoticed.

People also miss things they aren’t actively paying attention to or looking for. Psychologists call this inattentional blindness: Focusing on one task causes you to overlook other details, even obvious ones. In the famous invisible gorilla study, participants asked to count basketball passes in a video failed to notice someone in a gorilla suit walking through the middle of the scene.

YouTube video
If you’re counting how many passes the people in white make, do you even notice someone walk through in a gorilla suit?

Similarly, when your focus is on the broader content of an AI image, such as a cozy tiny home, you’re less likely to notice subtle distortions. In a way, the sixth finger in an AI image is today’s invisible gorilla − hiding in plain sight because you’re not looking for it.

Efficiency over accuracy in thinking

Our cognitive limitations go beyond visual perception. Human thinking uses two types of processing: fast, intuitive thinking based on mental shortcuts, and slower, analytical thinking that requires effort. When scrolling, our fast system likely dominates, leading us to accept images at face value.

Adding to this issue is the tendency to seek information that confirms your beliefs or reject information that goes against them. This means AI-generated images are more likely to slip by you when they align with your expectations or worldviews. If an AI-generated image of a basketball player making an impossible shot jibes with a fan’s excitement, they might accept it, even if something feels exaggerated.

While not a big deal for tiny home aesthetics, these issues become concerning when AI-generated images may be used to influence public opinion. For example, research shows that people tend to assume images are relevant to accompanying text. Even when the images provide no actual evidence, they make people more likely to accept the text’s claims as true.

Misleading real or generated images can make false claims seem more believable and even cause people to misremember real events. AI-generated images have the power to shape opinions and spread misinformation in ways that are difficult to counter.

Beating the machine

While AI gets better at detecting AI, humans need tools to do the same. Here’s how:

  1. Trust your gut. If something feels off, it probably is. Your brain expertly recognizes objects and faces, even under varying conditions. Perhaps you’ve experienced what psychologists call the uncanny valley and felt unease with certain humanoid faces. This experience shows people can detect anomalies, even when they can’t fully explain what’s wrong.
  2. Scan for clues. AI struggles with certain elements: hands, text, reflections, lighting inconsistencies and unnatural textures. If an image seems suspicious, take a closer look.
  3. Think critically. Sometimes, AI generates photorealistic images with impossible scenarios. If you see a political figure casually surprising baristas or a celebrity eating concrete, ask yourself: Does this make sense? If not, it’s probably fake.
  4. Check the source. Is the poster a real person? Reverse image search can help trace a picture’s origin. If the metadata is missing, it might be generated by AI.

AI-generated images are becoming harder to spot. During scrolling, the brain processes visuals quickly, not critically, making it easy to miss details that reveal a fake. As technology advances, slow down, look closer and think critically.The Conversation

Arryn Robbins, Assistant Professor of Psychology, University of Richmond

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Trump’s nomination for NASA leader boasts business and commercial spaceflight experience during a period of uncertainty for the agency

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theconversation.com – Wendy Whitman Cobb, Professor of Strategy and Security Studies, Air University – 2025-04-10 07:54:00

Jared Isaacman, the nominee for next NASA administrator, has traveled to orbit on two commercial space missions.
AP Photo/John Raoux

Wendy Whitman Cobb, Air University

Jared Isaacman, billionaire, CEO and nominee to become the next NASA administrator, faced questions on April 9, 2025, from members of the Senate Committee on Commerce, Science, and Transportation during his confirmation hearing for the position.

Should the Senate confirm him, Isaacman will be the first billionaire – but not the first astronaut – to head NASA. Perhaps even more significant, he will be the first NASA administrator with significant ties to the commercial space industry.

As a space policy expert, I know that NASA leadership matters. The head of the agency can significantly shape the missions it pursues, the science it undertakes and, ultimately, the outcome of America’s space exploration.

A man with short dark hair wearing a black jumpsuit with an American flag patch and the Polaris mission insignia.
Jared Isaacman speaks at a news conference in 2024, before his Polaris Dawn mission.
AP Photo/John Raoux, File

An unconventional background

At 16 years old, Isaacman dropped out of high school to start a payment processing company in his basement. The endeavor succeeded and eventually became known as Shift4.

Though he found early success in business, Isaacman also had a love for aviation. In 2009, he set a record for flying around the Earth in a light jet, beating the previous record by more than 20 hours.

While remaining CEO of Shift4, Isaacman founded another company, Draken International. The company eventually assembled the world’s largest fleet of privately owned fighter jets. It now helps to train U.S. Air Force pilots.

In 2019, Isaacman sold his stake in Draken International. In 2020, he took Shift4 public, making him a billionaire.

Isaacman continued to branch out into aerospace, working with SpaceX beginning in 2021. He purchased a crewed flight on the Falcon 9 rocket, a mission that eventually was called Inspiration4. The mission, which he led, represented the first private astronaut flight for SpaceX. It sent four civilians with no previous formal space experience into orbit.

Following the success of Inspiration4, Isaacman worked with SpaceX to develop the Polaris Program, a series of three missions to help build SpaceX’s human spaceflight capabilities. In fall 2024, the first of these missions, Polaris Dawn, launched.

Polaris Dawn added more accomplishments to Isaacman’s resume. Isaacman, along with his crewmate Sarah Gillis, completed the first private spacewalk. Polaris Dawn’s SpaceX Dragon capsule traveled more than 850 miles (1,367 kilometers) from Earth, the farthest distance humans had been since the Apollo missions.

A rocket launching into a dark sky, leaving behind a cloud of smoke.
The Polaris Dawn mission launched on a SpaceX Falcon 9 rocket in September 2024.
AP Photo/John Raoux

The next adventure: NASA

In December 2024, the incoming Trump administration announced its intention to nominate Isaacman for the post of NASA administrator.

As NASA administrator, Isaacman would oversee all NASA activities at a critical moment in its history. The Artemis program, which has been in progress since 2017, has several missions planned for the next few years.

This includes 2026’s Artemis II mission, which will send four astronauts to orbit the Moon. Then, in 2027, Artemis III will aim to land on it.

Four astronauts in blue NASA jumpsuits standing in front of a conical metal capsule.
If the mission proceeds as planned, the Artemis II crew will fly in an Orion crew capsule, pictured behind them, around the Moon in 2026.
Kim Shiflett/NASA via AP, File

But, if Isaacman is confirmed, his tenure would come at a time when there are significant questions about the Artemis program, as well as the extent to which NASA should use commercial space companies like SpaceX. The agency is also potentially facing funding cuts.

Some in the space industry have proposed scrapping the Artemis program altogether in favor of preparing to go to Mars. Among this group is the founder of SpaceX, Elon Musk.

Others have suggested canceling NASA’s Space Launch System, the massive rocket that is being used for Artemis. Instead, they argue that NASA could use commercial systems, like SpaceX’s Starship or Blue Origin’s New Glenn.

Isaacman has also dealt with accusations that he is too close to the commercial space industry, and SpaceX in particular, to lead NASA. This has become a larger concern given Musk’s involvement in the Trump administration and its cost-cutting efforts. Some critics are worried that Musk would have an even greater say in NASA if Isaacman is confirmed.

Since his nomination, Isaacman has stopped working with SpaceX on the Polaris Program. He has also made several supportive comments toward other commercial companies.

But the success of any of NASA’s plans depends on having the money and resources necessary to carry them out.

While NASA has been spared major cuts up to this point, it, like many other government agencies, is planning for budget cuts and mass firings. These potential cuts are similar to what other agencies such as the Department of Health and Human Services have recently made.

During his confirmation hearing, Isaacman committed to keeping the Artemis program, as well as the Space Launch System, in the short term. He also insisted that NASA could both return to the Moon and prepare for Mars at the same time.

Although Isaacman stated that he believed NASA had the resources to do both at the same time, the agency is still in a time of budget uncertainty, so that may not be possible.

About his relationship with Musk, Isaacman stated that he had not talked to Musk since his nomination in November, and his relationship with SpaceX would not influence his decisions.

Additionally, he committed to carrying out space science missions, specifically to “launch more telescopes, more probes, more rovers.”

But since NASA is preparing for significant cuts to its science budget, there is some speculation that the agency may need to end some science programs, like the Hubble space telescope, altogether.

Isaacman’s future

Isaacman has received support from the larger space community. Nearly 30 astronauts signed a letter in support of his nomination. Former NASA administrators, as well as major industry groups, have signaled their desire for Isaacman’s confirmation.

He also received the support of Senator Ted Cruz, the committee chair.

Barring any major development, Isaacman will likely be confirmed as NASA administrator by the Senate in the coming weeks. The Committee on Commerce, Science, and Transportation could approve his nomination once it returns from a two-week break at the end of April. A full vote from the Senate would follow.

If the Senate does confirm him, Isaacman will have several major issues to confront at NASA, all in a very uncertain political environment.The Conversation

Wendy Whitman Cobb, Professor of Strategy and Security Studies, Air University

This article is republished from The Conversation under a Creative Commons license. Read the original article.

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