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Microbes can colonize space, produce drugs and create energy − researchers are simulating their inner workings to harness how

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theconversation.com – Blaise Manga Enuh, Postdoctoral Research Associate in Microbial Genomics and Systems Biology, University of Wisconsin-Madison – 2025-01-06 07:19:00

Genome-scale metabolic models capture the complex chemical reactions that allow cells to function.
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Blaise Manga Enuh, University of Wisconsin-Madison

After so many years learning how microbes work, researchers are now digitally recreating their inner workings to tackle challenges ranging from climate change to space colonization.

In my work as a computational biologist, I research ways to get microbes to produce more useful chemicals, such as fuels and bioplastics, that can be used in the energy, agricultural or pharmaceutical industries. Traditionally, researchers have to conduct several trial-and-error experiments on petri dishes in order to determine the optimal conditions microbes need to produce high amounts of chemicals.

Instead, I am able to simulate these experiments all from behind a computer screen through digital blueprints that replicate the inside of microbes. Called genome-scale metabolic models, or GEMs, these virtual labs significantly reduce the time and cost required to figure out what researchers need to do to get what they’re looking for. With GEMs, researchers cannot only explore the complex network of metabolic pathways that allow living organisms to function, but also tweak, test and predict how microbes would behave in different environments, including on other planets.

As GEM technology continues to evolve, I believe these models will play an increasingly important role in shaping the future of biotechnology, medicine and space exploration.

What are genome-scale metabolic models?

Genome-scale metabolic models are digital maps of all the known chemical reactions that occur in cells – that is, the cell’s metabolism. These reactions are crucial for converting food into energy, building cellular structures and detoxifying harmful substances.

To create a GEM, I begin by analyzing an organism’s genome, which contains the genetic instructions cells use to produce proteins. A type of protein coded in the genome called enzymes are the workhorses of metabolism – they facilitate the conversion of nutrients into energy and building blocks for cells.

By linking the genes that encode enzymes to the chemical reactions they help make happen, I can build a comprehensive model that maps out the connections between genes, reactions and metabolites.

Once I build a GEM, I use some advanced computational simulations to make it work like a live cell or microbe would. One of the most common algorithms researchers use to do these simulations is called a flux balance analysis. This mathematical algorithm analyzes available data about metabolism, then makes predictions on how different chemical reactions and metabolites would act under specific conditions.

This makes GEMs particularly useful for understanding how organisms respond to genetic changes and environmental stresses. For example, I can use this method to predict how an organism will react when a specific gene is knocked out. I could also use it to predict how it might adapt to the presence of different chemicals in its environment or a lack of food.

Solving energy and climate challenges

Most of the chemicals used in agriculture, pharmaceuticals and fuels are obtained from fossil fuels. However, fossil fuels are a limited resource and significantly contribute to climate change.

Instead of extracting energy from fossil fuels, my team at the Great Lakes Bioenergy Research Center of the University of Wisconsin-Madison focuses on developing sustainable biofuels and bioproducts from plant waste. This includes cornstalk after the ears are harvested, nonedible plants such as grass, and algae. We study which crop wastes can be used for bioenergy, how to use microbes to convert them into energy, and ways to sustainably manage the land on which those crops are grown.

I am building a genome-scale metabolic model for Novosphingobium aromaticivorans, a species of bacteria that can convert very complex chemicals in plant waste to chemicals that are valuable to people, such as those used to make bioplastics, pharmaceuticals and fuels. With a clearer understanding of this conversion process, I can improve the model to more accurately simulate the conditions needed to synthesize greater amounts of these chemicals.

Researchers can then replicate these conditions in real life to generate materials that are cheaper and more accessible than those made from fossil fuels.

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Bioinformatics analyzes biological data to answer questions about living organisms.

Extreme microbes and space colonization

There are microbes on Earth that can survive in extremely harsh environments. For example, Chromohalobacter canadensis can live in extremely salty conditions. Similarly, Alicyclobacillus tolerans can thrive in very acidic environments.

Since other planets typically have similarly harsh climates, these microbes may not only be able to thrive and reproduce on these planets but could potentially change the environment so humans can live there as well.

Combining GEMs with machine learning, I saw that C. canadensis and A. tolerans can undergo chemical changes that help them survive in extreme conditions. They have special proteins in their cell walls that work with enzymes to balance the chemicals in their internal environment with the chemicals in their external environment.

With GEMs, scientists can simulate the environments of other planets to study how microbes survive without necessarily needing to go to those planets themselves.

The future of GEMs

Every day, researchers are generating large amounts of data about microbial metabolism. As GEM technology advances, it opens the door to exciting new possibilities in medicine, energy, space and other areas.

Synthetic biologists can use GEMs to design entirely new organisms or metabolic pathways from scratch. This field could advance biomanufacturing by enabling the creation of organisms that efficiently produce new materials, drugs or even food.

Whole human body GEMs can also serve as an atlas for the metabolics of complex diseases. They can help map how the chemical environment of the body changes with obesity or diabetes.

Whether it’s producing biofuels or engineering new organisms, GEMs provide a powerful tool for both basic research and industrial applications. As computational biology and GEMs advance, these technologies will continue to transform how scientists understand and manipulate the metabolisms of living organisms.The Conversation

Blaise Manga Enuh, Postdoctoral Research Associate in Microbial Genomics and Systems Biology, University of Wisconsin-Madison

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Trump’s opening tariff salvo will hurt US consumers − following through on Canada, Mexico threats will increase the price pain

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theconversation.com – Jason Reed, Associate Teaching Professor of Finance, University of Notre Dame – 2025-02-04 14:05:00

Trump’s opening tariff salvo will hurt US consumers − following through on Canada, Mexico threats will increase the price pain

Jason Reed, University of Notre Dame

If U.S. voters reelected Donald Trump hoping for relief from higher prices, his recent threats to impose tariffs on America’s three largest trade partners might make them think again.

On Saturday, Feb. 1, Trump announced 25% tariffs on Canada and Mexico and 10% tariffs on China, which he said would take effect on Tuesday, Feb. 4. While markets braced for the news to some degree, they still saw a steep premarket sell-off on Monday, Feb. 3, followed by morning volatility.

While Canada and Mexico negotiated monthlong reprieves on Monday, the new tariffs on China went into effect as expected Tuesday, Feb. 4. And while the ultimate shape of Trump’s tariff policy remains to be seen, the president warned that American consumers could feel “some pain” as a result.

Given my training as an economist and finance professor, I think Trump could be right on that score. In fact, if the tariffs go into effect, they could spell disaster for the Federal Reserve’s inflation reduction efforts.

From grocery stores to homes

U.S. consumers might be surprised to find out that almost every economic sector could be affected by this opening salvo of tariffs, should they go ahead in March. Imports from Mexico and Canada reached close to US$1 trillion in 2024, almost double the amount the U.S. imports from China.

The U.S. is particularly reliant on Mexico for fresh fruits and vegetables, and on Canada for lumber. So if the tariffs go into effect, Americans who have been waiting for home prices to ease may have to continue waiting, as tariffs on lumber and other building materials could worsen the affordable-housing crunch. And let’s not even talk about avocado prices.

Meanwhile, the 10% tariffs on Chinese goods will likely boost the price of electronics, and China has already imposed retaliatory measures. Trump has also proposed 25% tariffs on Taiwan and its semiconductor industry, in an attempt to push Taiwanese companies to invest more in U.S. manufacturing. If that tariff were to go into effect, prices for U.S. consumers would be even higher.

A tax by any other name …

Tariffs are an import tax. They’re passed through the supply chain in the form of higher prices and are eventually paid by consumers. Traditionally, governments have used tariffs as a fiscal tool to encourage businesses and consumers to move away from foreign-made products and support domestic businesses instead.

In theory, new tariffs could encourage foreign businesses to invest in the U.S. and make more stuff on American soil. Unfortunately, domestic manufacturing has seen a systemic decline since the 1980s, resulting in lower prices for consumers but severely limiting U.S.-produced products. In the short term, at least, import taxes on Canadian, Mexican and Chinese products would ultimately be paid by U.S. consumers.

Although this round of tariff threats may seem arbitrary to some, the Trump administration says it considers tariffs deeply intertwined with national security concerns. Stephen Miran, Trump’s pick to chair the president’s Council of Economic Advisers, has laid out a path for Trump’s tariff plan, which he says is aimed at putting American industry on fairer ground against the rest of the world.

In the long term, it’s unclear whether Trump’s threatened trade war will bring domestic manufacturing back to the U.S. and start a new industrial renaissance. In the meantime, American consumers will likely be stuck holding the bag.The Conversation

Jason Reed, Associate Teaching Professor of Finance, University of Notre Dame

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As allies prepare to strike back, a costly trade war looms

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theconversation.com – Bedassa Tadesse, Professor of Economics, University of Minnesota Duluth – 2025-02-04 13:43:00

Trump’s tariff gambit: As allies prepare to strike back, a costly trade war looms

Bedassa Tadesse, University of Minnesota Duluth

On Saturday, Feb. 1, 2025, U.S. President Donald Trump announced a plan to slap steep tariffs on imports from key American trading partners – 25% on goods from Mexico and Canada and 10% on imports from China. His stated reason? To curb illegal immigration and drug trafficking.

Both Mexico and Canada managed to buy some time. After urgent phone calls with Trump on Feb. 3, their leaders each secured a one-month reprieve. But Mexico’s Claudia Sheinbaum and Canada’s Justin Trudeau also made it clear to their U.S. counterpart: If these tariffs go through, they’ll hit back with their own trade restrictions. The world is watching the opening moves of what could become another costly trade war.

As a professor of economics, I can explain why this poses significant risks to the U.S. economy and American consumers. Economic theory suggests that tariffs distort market efficiency, raising production costs while limiting consumer choice and increasing prices.

Who really pays for tariffs?

While politicians often frame tariffs as a way to punish other countries, they actually hit domestic consumers and businesses hardest. Whether they’re facing higher grocery bills or disruptions in manufacturing, Americans will feel the strain.

When tariffs are imposed, companies must either absorb the additional costs – cutting into profits and potentially threatening jobs – or pass these costs to consumers through higher prices. Small businesses operating on thin profit margins are particularly vulnerable, as many lack the resources to quickly switch suppliers.

Tariffs trigger costly retaliation

Worse yet, such measures commonly set off a cycle of retaliation. During past trade disputes involving the U.S., affected nations have responded with counter-tariffs on American products, including textiles, steel and agricultural goods. Such retaliatory efforts have led to sharp declines in U.S. exports.

During the first Trump administration, for example, China imposed retaliatory tariffs on U.S. agricultural exports. As a result, the U.S. farmers lost billions of dollars, and the U.S. spent billions in government aid to offset those losses. China has already issued new tariffs on imports of U.S. goods and export controls on some of its exports to the U.S. to retaliate for Trump’s current move.

History also shows that trade wars are self-defeating. The Smoot-Hawley Tariff Act of 1930, which imposed tariffs on over 20,000 imported goods, prompted swift retaliation from trading partners and contributed to deepening the Great Depression.

Modern trade wars have other consequences

Modern trade wars hit closer to home than most Americans realize. The recent tariff threat against Colombia reveals why. In 2023, Colombian farmers supplied US$1.14 billion worth of fresh-cut flowers to U.S. florists. In a near-crisis that lasted a weekend, Trump threatened to slap steep tariffs on the South American nation, right when flower shops across America were stocking up for one of their busiest seasons: Valentine’s Day.

The same tariffs would have hit Colombian coffee too, affecting everything from neighborhood cafes to grocery store prices. This shows how modern trade disputes can instantly disrupt the everyday purchases Americans make.

Other key trading partners, including the European Union, have also come into the crosshairs. On Jan. 30, 2025, the president issued a stark warning to Brazil, Russia, India, China and South Africa – the so-called BRICS nations – threatening 100% tariffs if they continued efforts to reduce reliance on the U.S. dollar as their reserve currency.

These threats can do more than alienate strategic partners; they risk accelerating dedollarization – pushing nations to develop alternative financial systems that weaken U.S. influence in global trade.

A more effective approach

Beyond causing immediate economic pain, constant tariff threats risk damaging America’s credibility as a reliable trading partner. The U.S. helped establish the rules-based international trading system, but regular tariff threats erode global trust and push trading partners to seek alternatives to the U.S. market.

The reality is clear: No country in the modern era has successfully used tariffs to grow its economy or improve the well-being of its people. The countries that are most dependent on tariff revenues for their national budgets are among the world’s poorest and least developed economies.

I believe the path to maintaining America’s economic leadership lies in embracing a smarter, more strategic trade policy – one that builds alliances instead of breaking them. A strategy that prioritizes negotiation, fosters innovation and enhances competitiveness – and that doesn’t rely on protectionist tactics more often used by developing nations – would strengthen cooperation and stability, ensuring long-term economic prosperity.The Conversation

Bedassa Tadesse, Professor of Economics, University of Minnesota Duluth

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Who are immigrants to the US, where do they come from and where do they live?

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theconversation.com – Jennifer Van Hook, Distinguished Professor of Sociology and Demography, Penn State – 2025-02-04 13:42:00

Who are immigrants to the US, where do they come from and where do they live?

Immigrants to the U.S. increasingly arrive like these people, seeking asylum at a formal border crossing, rather than trying to sneak across the border.
Carlos Moreno/NurPhoto via Getty Images

Jennifer Van Hook, Penn State

Undocumented immigration is a key issue in American politics, but it can be hard to nail down the basic facts about who these immigrants are, where they live and how their numbers have changed in the past few decades.

I study the demographics of the U.S. immigrant population and have seen how the data has changed over time. Here are some basics to set the stage as President Donald Trump begins his second term in office vowing to crack down hard on immigrants, including by conducting mass deportations.

Immigration status

My analysis of the Census Bureau’s 2023 American Community Survey data, in collaboration with the Migration Policy Institute, a nonpartisan nonprofit immigration research group, finds that as of the middle of 2023, approximately 51 million foreign-born people lived in the United States.

Most immigrants are in the U.S. legally. About 49% have become U.S. citizens by a process known as naturalization. Another 19% hold lawful permanent resident status and are eligible to become U.S. citizens through naturalization. Still another 5% are in the country on temporary visas, like those for international students, diplomats and their families, and seasonal or temporary workers.

The remaining 27% – around 13.7 million people – are outside those categories and therefore generally considered to be undocumented.

My analysis shows that the number of undocumented immigrants held steady at around 11 million between 2007 and 2019. In the next four years, the numbers increased by nearly 3 million. This recent growth is mostly attributable to large increases in border crossings by migrants from Central and South America who were seeking asylum or other forms of humanitarian relief. Starting in June 2024, however, the number of people entering across the U.S.-Mexico border fell back to normal levels when the Biden administration implemented the Secure the Border rule, which suspends asylum applications at the border when crossings reach a seven-day average of 2,500.

These changes were accompanied by changes in the undocumented migration process itself. In the past, undocumented immigrants often entered the country by slipping undetected across the U.S. border with Mexico. But increased border enforcement made the journey more dangerous and expensive.

Instead of paying smugglers or risking their lives in the desert, growing numbers of undocumented immigrants now either directly approach immigration officials at airports or land-border crossings and seek asylum in the U.S. Others are initially admitted to the country legally on a temporary tourist, student or work visa – but then overstay the time period for which they have permission.

Additionally, growing numbers of undocumented immigrants occupy what might be called a “liminal” or “in-between” status. The Migration Policy Institute analysis estimates this encompasses a range of groups as of the middle of 2023, including:

  • About 2.1 million people awaiting a decision on their asylum claims.
  • 521,000 parolees, allowed into the U.S. for humanitarian or national security reasons, like those paroled recently from Afghanistan and Ukraine.
  • 654,000 people who hold temporary protected status because it would be unsafe for them to return home due to armed conflict, natural disasters and other emergencies.
  • 562,000 who are protected by the Deferred Action for Childhood Arrivals program because they were brought to the United States as children by their parents.

The report estimates that just over one-quarter of undocumented immigrants currently occupy this type of “in-between” status. These immigrants are protected from deportation. Some even have a legal right to work in the U.S. Yet they do not possess a durable legal immigration status, and their rights could be threatened by policy changes.

While Trump says he wants to deport as many as 11 million immigrants, analyses published by The New York Times and The Washington Post indicate that it may be difficult to remove many of them under existing U.S. law. The one group that is easy to remove – those with a criminal record – is relatively small, numbering about 650,000.

Shifting countries of origin

Since 1980, Mexicans have been the largest single national origin group in the United States. I found that 10.9 million Mexican-born individuals were living in the country in 2023, making up 23% of all immigrants. The second-largest group, immigrants from India, numbered just 2.9 million, or 6% of all immigrants living in the U.S.

However, immigrants’ origins have been shifting away from Mexico.

With the onset of the Great Recession of 2007-2009, work opportunities in U.S. construction and manufacturing evaporated. Many Mexican laborers had been working in construction at the time but went back to Mexico when the U.S. housing market collapsed.

At that same time, Mexico’s economic conditions improved, its population growth slowed, and many would-be migrants opted to stay home. For the first time in decades, from 2007 to 2022 the number of Mexicans who returned home exceeded the number coming to the United States.

This trend was especially pronounced among undocumented immigrants. I found that Mexicans made up about 51% of the undocumented immigrants who arrived in the country 10 or more years ago. Central Americans made up 20%, and the remaining originated from other regions.

However, undocumented migrants now come from across the globe. Among undocumented immigrants who arrived within the past 10 years, 19% came from Mexico. Larger shares came from Central America and South America. While some of these new migrants seek work, others flee crime, economic and ecological disasters, and political persecution in their home countries.

Duration of residence

Most immigrants, whether they are in the U.S. legally or illegally, have lived in the United States for many years. Just under half of foreign-born individuals have lived in the country for two decades or more, and more than two-thirds have lived in the country for at least 10 years. Only 20% arrived within the past five years.

This is a dramatic change from the early 2000s, when less than 10% of immigrants had been in the U.S. for more than two decades, and more than one-third had arrived within the previous five years.

That means many of the people who are likely to be targeted for deportation in the coming months are settled, long-term members of American society.

Place of residence

As of 2023, 6.6 million immigrants reported on the Census Bureau’s American Community Survey that they moved to the United States in the past five years.

However, the effects of these new immigrants on American communities has been uneven. Although most communities are more racially and ethnically diverse now than in the past, the numbers of newly arrived immigrants are relatively low in most places.

Fifteen states host fewer than 20,000 immigrants, and 33 states are home to fewer than 100,000. In contrast, over half of new arrivals live in just five states: California, Florida, Illinois, New York and Texas are the home of over half of new arrivals yet have only 37% of the U.S. population. Other states such as Georgia, Michigan, New Jersey, North Carolina, Pennsylvania and Washington also are home to large and growing immigrant populations.

The U.S. immigrant population is changing rapidly. In the early years of the 21st century, Mexican immigrants dominated undocumented immigration flows to the United States. Decades later, many of these people continue to live in the country.

In the past four years, however, the flow of undocumented people increased dramatically. These new arrivals tend to come from troubled nations in Central and South America, many of whom are protected from deportation and have a legal right to work in the U.S. Altogether, most undocumented immigrants either have lived in the country for decades or have legal protections.

Neither of these groups fit the profile of undocumented immigrants who are typically targeted for deportation.The Conversation

Jennifer Van Hook, Distinguished Professor of Sociology and Demography, Penn State

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