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Many stable atoms have ‘magic numbers’ of protons and neutrons − 75 years ago, 2 physicists discovered their special properties

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theconversation.com – Artemis Spyrou, Professor of Nuclear Physics, Michigan – 2024-10-07 13:55:12

The linear accelerator at the Facility for Rare Isotope Beams, where researchers study rare isotopes of elements.
Facility for Rare Isotope Beams

Artemis Spyrou, Michigan State University and Sean Liddick, Michigan State University

The word magic is not often used in the context of science. But in the early 1930s, scientists discovered that some atomic nuclei – the center part of atoms, which make up all matter – were more stable than others. These nuclei had specific numbers of protons or neutrons, or magic numbers, as physicist Eugene Wigner called them.

A headshot of Maria Goeppert Mayer
Maria Goeppert Mayer won the 1963 Nobel Prize in physics.
Argonne National Laboratory, CC BY-NC-SA

The race to figure out what made these nuclei so stable began. Understanding these magic numbers would allow scientists to predict the properties of other nuclei, such as their mass or how long they are expected to . With that, scientists could also predict which combinations of protons and neutrons can result in a nucleus.

The solution to the puzzle came in 1949 from two directions simultaneously. In the U.S., physicist Maria Goeppert Mayer published an explanation, at the same time as a group of scientists led by J. Hans D. Jensen in Germany found the same solution.

A headshot of Hans D. Jensen.
Hans Daniel Jensen won the 1963 Nobel Prize in physics.
The Nobel Foundation

For their discovery, the two physicists each got a quarter of the 1963 Nobel Prize in physics. We’re two nuclear scientists whose work is built on Goeppert Mayer’s and Jensen’s discoveries 75 years ago. These magic numbers continue to play an important role in our research, only now we can study them in nuclei that live for just a fraction of a second.

Stability in the atom

The atom is a complex system of particles. It’s made up of a central nucleus consisting of protons and neutrons, called nucleons, with electrons orbiting around the nucleus.

Nobel prize-winning physicist Niels Bohr described these electrons in the atom as existing in a shell structure. The electrons circulate around the nucleus in particular energy levels, or orbits. These orbits have specific energies, and each orbit can hold only so many electrons.

Chemical reactions result from interactions between the electrons in two atoms. In Bohr’s model, if an electron orbit is not already filled, then it’s easier for the atoms to exchange or share those electrons and induce chemical reactions.

A diagram of an atom with a nucleus of protons and neutrons, and rings of electrons orbiting.
The Bohr model of the atom.
AG Caesar/Wikimedia Commons, CC BY-SA

One class of elements, the noble gases, hardly ever react with other elements. In noble gases, the electrons occupy completely filled orbits, and as a result the atoms greedily hold onto their electrons instead of sharing and undergoing a chemical reaction.

In the 1930s, scientists wondered whether protons and neutrons might also occupy orbits, like electrons. But nobody could show this conclusively. For more than a decade, the scientific community was unable to describe the nucleus in terms of individual protons and neutrons. Scientists used a more simplified picture, one that treated protons and neutrons as one single system, like a drop of .

Magic numbers

In 1949, Goeppert Mayer and Jensen developed the so-called shell model of the nucleus.
Protons and neutrons occupy particular orbits, analogous to electrons, but they also have a property called spin – similar to a spinning top. Goeppert Mayer and Jensen found that when combining the two properties in their calculations, they were able to reproduce the experimental observations.

Through some experiments, they found that nuclei with certain magic numbers of neutrons or protons are unusually stable and hold onto their nucleons more than researchers previously expected, just like how noble gases hold onto their electrons.

The magic numbers known to scientists are 2, 8, 20, 28, 50, 82 and 126. They are the same for both protons and neutrons. When a nucleus has a magic number of protons or neutrons, then the particular orbit is filled, and the nucleus is not very reactive, similar to the noble gases.

For example, the element tin has a magic number of protons. Tin always has 50 protons, and its most common isotope has 70 neutrons. Isotopes are atoms of the same element that have a different number of neutrons.

There are nine other stable isotopes of tin that can exist – it’s the element with the largest number of stable isotopes. A stable isotope will never spontaneously change into a different element, which is what happens to radioactive isotopes.

Helium, with two protons and two neutrons, is the lightest “doubly magic” nucleus. Both its neutron count and its proton count are a magic number. The forces that hold the helium-4 nucleus together are so strong that it’s impossible to attach another proton or neutron. If you tried to add another proton or neutron, the resulting atom would fall apart instantaneously.

On the other hand, the heaviest stable nucleus in existence, -208, is also a doubly magic nucleus. It has magic numbers of 82 protons and 126 neutrons.

A diagram showing the density of stable isotopes as protons and neutrons increase, with most concentrated around the magic numbers.
Many stable isotopes have magic numbers of protons and neutrons.
The Facility for Rare Isotope Beams

Examples of magic numbers and stable nuclei exist everywhere – but scientists couldn’t explain them without the introduction of the shell model.

Stable nuclei in nature

The shell structure in nuclei tells researchers about how elements are distributed across the Earth and throughout the universe.

One of the most abundant elements on our planet and in the human body is oxygen, in particular the isotope oxygen-16.

With eight protons and eight neutrons, oxygen-16 has an extremely stable nucleus. A nearby star produced the oxygen we find on Earth through nuclear reactions in its core sometime before the solar system was formed.

Since oxygen nuclei are doubly magic, these nuclei in the star did not interact very much with other nuclei. So more oxygen was left around to eventually act as an essential ingredient for on Earth.

In her Nobel lecture, Maria Goeppert Mayer talked about the work she did with physicist Edward Teller. The two had attempted to describe how these elements formed in . In the 1930s, it was impossible for them to explain why certain elements and isotopes were more abundant in stars than others. She later found that the increased abundances corresponded to nuclei with something in common: They all had magic numbers of neutrons.

With the shell model and the explanation of magic numbers, the production of elements in stars was possible and was published in 1957.

Scientists continue to use ideas from the nuclear shell model to explain new phenomena in nuclear science. A few accelerator facilities, such as the Facility for Rare Isotope Beams, where we work, aim to create more exotic nuclei to understand how their properties change with their stable counterparts.

At the Facility for Rare Isotope Beams, scientists produce new isotopes by accelerating stable isotopes to about half the speed of light and smashing them at a target. Out of the pieces, we select the rarest ones and study their properties.

Possibly the most profound modern discovery is the fact that the magic numbers change in exotic nuclei like the type we create here. So, 75 years after the original discovery, the race to discover the next magic number is still on.The Conversation

Artemis Spyrou, Professor of Nuclear Physics, Michigan State University and Sean Liddick, Associate Professor of Chemistry, Michigan State University

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MicroRNA is the Nobel-winning master regulator of the genome – researchers are learning to treat disease by harnessing how it controls genes

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theconversation.com – Andrea Kasinski, Associate Professor of Biological Sciences, Purdue University – 2024-10-07 08:59:10

RNA is more than just a transitional between DNA and protein.
Christoph Burgstedt/Science Photo Library via Getty Images

Andrea Kasinski, Purdue University

When Victor Ambros and Gary Ruvkun discovered a new molecule they called microRNA in the 1980s, it was a fascinating diversion from what for decades had been called the central dogma of molecular biology.

Recognized with the 2024 Nobel Prize in physiology or medicine, Ambros and Ruvkun had identified a new kind of genetic material that transformed how researchers understood gene regulation.

Like DNA, RNA is a form of genetic material made from individual nucleotides linked into chains. According to the central dogma, genetic information flows in one direction: DNA is transcribed into RNA, and RNA is translated into proteins. But in one major deviation from the central dogma, some RNAs are never translated or coded into proteins.

MicroRNA is one type of these so-called noncoding RNAs. They’re short stretches of genetic material that, rather than coding for a specific protein themselves, control the RNAs that do code for proteins. In effect, microRNAs turn particular genes on and off.

I dedicated my scientific career to understanding how RNA works, in part because research on RNA has lagged behind other macromolecules like DNA and proteins. The Nobel Prize recognition of microRNA molecules marks both their importance in biology and their promise as potential treatments for various diseases, including cancer.

MicroRNAs play a key role in regulating gene expression.

MicroRNAs and disease

Scientists regard microRNAs as master regulators of the genome due to their ability to bind to and alter the expression of many protein-coding RNAs. Indeed, a single microRNA can regulate anywhere from 10 to 100 protein-coding RNAs. Rather than translating DNA to proteins, they instead can bind to protein-coding RNAs to silence genes.

The reason microRNAs can regulate such a diverse pool of RNAs stems from their ability to bind to target RNAs they don’t perfectly match up with. This means a single microRNA can often regulate a pool of targets that are all involved in similar processes in the cell, leading to an enhanced response.

Because a single microRNA can regulate multiple genes, many microRNAs can contribute to disease when they become dysfunctional.

In 2002, researchers first identified the role dysfunctional microRNAs play in disease through patients with a type of blood and bone marrow cancer called chronic lymphocytic leukemia. This cancer results from the loss of two microRNAs normally involved in blocking tumor cell growth. Since then, scientists have identified over 2,000 microRNAs in people, many of which are altered in various diseases.

The field has developed a fairly solid understanding of how microRNA dysfunction contributes to disease. Changing one microRNA can change several other genes, resulting in a plethora of alterations that can collectively reshape the cell’s physiology. For example, over half of all cancers have significantly reduced activity in a microRNA called miR-34a. Because miR-34a regulates many genes involved in preventing the growth and migration of cancer cells, losing miR-34a can increase the risk of developing cancer.

Researchers are looking into using microRNAs as for cancer, heart disease, neurodegenerative disease and others. While results in the laboratory have been promising, bringing microRNA treatments into the clinic has met multiple challenges. Many are related to inefficient delivery into target cells and poor stability, which limit their effectiveness.

Diagram showing a loop of microRNA binding to a strand of mRNA as it's being translated from DNA
MicroRNA can silence genes by binding to mRNA.
Kajsa Mollersen/Wikimedia Commons, CC BY-SA

Delivering microRNA to cells

One reason why delivering microRNA treatments into cells is difficult is because microRNA treatments need to be delivered specifically to diseased cells while avoiding healthy cells. Unlike mRNA COVID-19 vaccines that are taken up by scavenging immune cells whose job is to detect foreign materials, microRNA treatments need to fool the body into thinking they aren’t foreign in order to avoid immune attack and get to their intended cells.

Scientists are studying various ways to deliver microRNA treatments to their specific target cells. One method garnering a great deal of attention relies on directly linking the microRNA to a ligand, a kind of small molecule that binds to specific proteins on the surface of cells. with healthy cells, diseased cells can have a disproportionate number of some surface proteins, or receptors. So, ligands can microRNAs home specifically to diseased cells while avoiding healthy cells. The first ligand approved by the U.S. Food and Drug Administration to deliver small RNAs like microRNAs, N-acetylgalactosamine, or GalNAc, preferentially delivers RNAs to liver cells.

Identifying ligands that can deliver small RNAs to other cells requires finding receptors expressed at high enough levels on the surface of target cells. Typically, over one million copies per cell are needed in order to achieve sufficient delivery of the drug.

One ligand that stands out is folate, also referred to as vitamin B9, a small molecule critical during periods of rapid cell growth such as fetal . Because some tumor cells have over one million folate receptors, this ligand provides sufficient opportunity to deliver enough of a therapeutic RNA to target different types of cancer. For example, my laboratory developed a new molecule called FolamiR-34a – folate linked to miR-34a – that reduced the size of breast and lung cancer tumors in mice.

Microscopy image juxtaposing endothelial cells sprouting extensions to form new blood vessels and a cell bathed in microRNA unable to sprout
Tumors can exploit healthy cells to grow blood vessels that them nutrients, as seen in the endothelial cells to the left sprouting extensions. Exposing these cells to certain microRNAs, however, can disable that growth, as seen in the cell to the right.
Dudley Lab, University of Virginia School of Medicine/NIH via Flickr, CC BY-NC

Making microRNAs more stable

One of the other challenges with using small RNAs is their poor stability, which to their rapid degradation. As such, RNA-based treatments are generally short-lived in the body and require frequent doses to maintain a therapeutic effect.

To overcome this , researchers are modifying small RNAs in various ways. While each RNA requires a specific modification pattern, successful changes can significantly increase their stability. This reduces the need for frequent dosing, subsequently decreasing treatment burden and cost.

For example, modified GalNAc-siRNAs, another form of small RNAs, reduces dosing from every few days to once every six months in nondividing cells. My team developed folate ligands linked to modified microRNAs for cancer treatment that reduced dosing from once every other day to once a . For diseases like cancer where cells are rapidly dividing and quickly diluting the delivered microRNA, this increase in activity is a significant advancement in the field. We anticipate this accomplishment will facilitate further development of this folate-linked microRNA as a cancer treatment in the years to come.

Many labs are working to develop treatments based on the discoveries new Nobel laureates Ambros and Ruvkun made decades ago. While there’s still considerable work to be done to overcome the hurdles associated with microRNA treatments, it’s clear that RNA shows promise as a therapeutic for many diseases.

This is an updated version of an article originally published on Nov. 29, 2023.The Conversation

Andrea Kasinski, Associate Professor of Biological Sciences, Purdue University

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NASA wants to send humans to Mars in the 2030s − a crewed mission could unlock some of the red planet’s geologic mysteries

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theconversation.com – Joel S. Levine, Research Professor, Department of Applied Science, William & Mary – 2024-10-07 07:20:41

Mars’ craters come from ancient collisions during the formation of the solar system.

NASA/JPL-Caltech/Cornell University/Arizona State University via AP

Joel S. Levine, William & Mary

NASA plans to send humans on a scientific round to Mars potentially as early as 2035. The trip will take about six to seven months each way and will up to 250 million miles (402 million kilometers) each way. The astronauts may spend as many as 500 days on the planet’s surface before returning to Earth.

NASA’s Artemis program plans to return humans to the Moon this decade to practice and prepare for a Mars mission as early as the 2030s. While NASA has several reasons for pursuing such an ambitious mission, the biggest is scientific exploration and discovery.

I’m an atmospheric scientist and former NASA researcher involved in establishing the scientific questions a Mars mission would investigate. There are lots of mysteries to investigate on the red planet, why Mars looks the way it does today, and whether it has ever hosted , past or present.

Mars, a dusty reddish planet, floating in space.

Studying Mars can tell researchers more about the formation of the solar system.

J. Bell/NASA via AP

Mars geology

Mars is an intriguing planet from a geological and atmospheric perspective. It formed with the rest of the solar system about 4.6 billion years ago. Around 3.8 billion years ago, the same time that life formed on Earth, early Mars was very Earth-like. It had abundant liquid water on its surface in the form of oceans, lakes and rivers and possessed a denser atmosphere.

While Mars’ surface is totally devoid of liquid today, scientists have spotted evidence of those past lakes, rivers and even an ocean coastline on its surface. Its north and south poles are covered in frozen water, with a thin veneer of frozen carbon dioxide. At the south pole during the summer, the carbon dioxide veneer disappears, leaving the frozen water exposed.

Today, Mars’ atmosphere is very thin and about 95% carbon dioxide. It’s filled with atmospheric dust from the surface, which gives the atmosphere of Mars its characteristic reddish color.

Scientists know quite a bit about the planet’s surface from sending robotic missions, but there are still many interesting geologic features to investigate more closely. These features could tell researchers more about the solar system’s formation.

The northern and southern hemispheres of Mars look very different. About one-third of the surface of Mars – mostly in its northern hemisphere – is 2 to 4 miles (3.2-6.4 kilometers) lower in elevation, called the northern lowlands. The northern lowlands have a few large craters but are relatively smooth. The southern two-thirds of the planet, called the southern highlands, has lots of very old craters.

Mars also has the largest volcanoes that scientists have observed in the solar system. Its surface is peppered with deep craters from asteroid and meteor impacts that occurred during the early history of Mars. Sending astronauts to study these features can researchers understand how and when major happened during the early history of Mars.

Mars’ volcanoes tower over any of the highest mountains on Earth.

Asking the right questions

NASA formed a panel called the Human Exploration of Mars Science Analysis Group to plan the future mission. I co-chaired the panel, with NASA scientist James B. Garvin, to develop and assess the key scientific questions about Mars. We wanted to figure out which research questions required a human mission to address, rather than cheaper robotic missions.

The panel came up with recommendations for several important scientific questions for human investigation on Mars.

One question asks whether there’s life on the planet today. Remember, life on Earth formed about 3.8 billion years ago, when Earth and Mars were similar-looking planets that both had abundant liquid water and Mars had a denser atmosphere.

Another question asks what sort of environmental changes led Mars to lose the widespread, plentiful liquid water on its surface, as well as some of its atmosphere.

These questions, alongside other recommendations from the panel, made it into NASA’s architectural plan for sending humans to Mars.

How do you get to Mars?

To send people to Mars and return them safely to Earth, NASA has developed a new, very powerful launch vehicle called the Space Launch System and a new human carrier spacecraft called Orion.

To prepare and train astronauts for living on and exploring Mars, NASA established a new program to return humans to the Moon, called the Artemis program.

In mythology, Artemis was Apollo’s twin sister. The Artemis astronauts will and work on the Moon for months at a time to prepare for living and working on Mars.

The Artemis program plans to return humans to the Moon, in anticipation of eventually sending humans to Mars.

The Space Launch System and Orion successfully launched on Nov. 16, 2022, as part of the Artemis I mission. It made the Artemis program’s first uncrewed flight to the Moon, and once there, Orion orbited the Moon for six days, getting as close as 80 miles (129 kilometers) above the surface.

Artemis I splashed back down to Earth on Dec. 11, 2022, after its 1.4 million-mile (2.2 million-kilometer) maiden journey.

Artemis III, the first mission to return humans to the lunar surface, is scheduled for 2026. The Artemis astronauts will land at the Moon’s south pole, where scientists believe there may be large deposits of subsurface water in the form of ice that astronauts could mine, melt, purify and drink. The Artemis astronauts will set up habitats on the surface of the Moon and spend several months exploring the lunar surface.

Since the Moon is a mere 240,000 miles (386,000 km) from Earth, it will act as a ground for the future human exploration of Mars. While a Mars mission is still many years out, the Artemis program will help NASA develop the capabilities it needs to explore the red planet.The Conversation

Joel S. Levine, Research Professor, Department of Applied Science, William & Mary

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When and why do girls start forming cliques?

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theconversation.com – Hannah L. Schacter, Assistant Professor of Psychology, University – 2024-10-07 07:20:25

A clique is a group whose members spend a lot of time together.

pixdeluxe/E+ via Getty Images

Hannah L. Schacter, Wayne State University

Curious Kids is a for children of all ages. If you have a question you’d like an expert to answer, send it to curiouskidsus@theconversation.com.


When and why do girls start forming cliques? – Anushka, age 14, California


The Plastics. Will, Mike, Dustin, Lucas, Max and Eleven, also known as The Party. The Pink Ladies. Teenage Mutant Ninja Turtles. These groups from different decades, universes, shows and movies, but they all have one thing in common: They’re cliques.

Ever wondered why people form these tight-knit groups? Scientists have, and they’ve done research to try to answer this question.

I’m a psychology professor who studies how kids and teens interact with their peers. I research both the good and bad parts of teen relationships, friendships and bullying. Cliques can be a natural part of those relationships.

What are cliques?

Simply put, cliques are groups of people who spend a lot of time together. Although you might think cliques are just for girls, anyone can be part of a clique, no matter their gender. They can also range in size, with some including just a few kids and others with up to nine or 10 members.

Typically, people in a clique have things in common, such as what clothes they wear, where they like to hang out, the sport they play or what music they listen to. Some kids also belong to multiple cliques that reflect their different interests and activities. For example, you might hang out with a group of kids from drama club at school and another group of kids from your travel soccer team on weekends.

When and why do cliques form?

It’s human nature for people to want to be a part of a group. For thousands of years, being part of a group has been a way for people to stay safe from predators and get better access to important resources, such as food and shelter. Belonging to a group can also make you feel safe and supported.

Believe it or not, cliques can start forming as early as preschool. Kids of all ages like to be connected with peers who share their interests and make them feel included.

Cliques become more common and influential, however, during late childhood and adolescence. with younger kids, spend more time with their peers in and outside of school. Plus, their brains go through changes that make them want to be around friends and fit in more.

dejected tween boy stands with arms crossed in foreground, in background three other boys talk together

Your feelings about a clique may depend on whether you’re in it or on the outside.

Digital Vision/Photodisc via Getty Images

How do cliques affect members and outsiders?

Cliques can have both good and bad effects. If you’re in a clique with nice and fun kids, you might feel less anxious and more confident. But if you’re in a clique with kids who are mean or break the rules, you might also start to act in negative ways and have problems with friends or romantic relationships in the future.

Cliques can sometimes make others feel left out. Even though everyone wants to feel safe and supported, some kids get really focused on being popular – in the , they might exclude others. Kids who aren’t in a clique or who are at the bottom of the clique hierarchy might feel more lonely and sad.

The power of friendship

Although cliques can be tough to navigate, you don’t need to be in a big group to feel happy and supported. Even having a couple of good friends can make a big difference.

Friendships are special because they’re all about mutual respect and caring, not just to fit in. If you’re struggling with cliques at school, keep in mind that having one or two close friends who know you really well and are always there for you can be just as meaningful and fun as being in any clique.

Making friends can be hard, but remember, everyone is trying to find their own niche in the world. Hang out with people who make you feel good and who have your back. It’s not about having the biggest or coolest group – it’s about finding the right people who support you.


Hello, curious kids! Do you have a question you’d like an expert to answer? Ask an adult to send your question to CuriousKidsUS@theconversation.com. Please tell us your name, age and the city where you live.

And since curiosity has no age limit – adults, let us know what you’re wondering, too. We won’t be able to answer every question, but we will do our best.The Conversation

Hannah L. Schacter, Assistant Professor of Psychology, Wayne State University

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