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Iron fuels immune cells – and it could make asthma worse

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theconversation.com – Benjamin Hurrell, Assistant Professor of Research in Molecular Microbiology and Immunology, of Southern California – 2024-05-14 07:13:50

Iron carries oxygen throughout the body, but ironically, it can also make it harder to breathe for people with asthma.

Hiroshi Watanabe/Stone via Getty Images

Benjamin Hurrell, University of Southern California and Omid Akbari, University of Southern California

You've likely heard that you can get iron from eating spinach and steak. You might also know that it's an essential trace element that is a major component of hemoglobin, a protein in red blood cells that carries oxygen from your lungs to all parts of the body.

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A lesser known important function of iron is its involvement in generating energy for certain immune cells.

In our lab's newly published research, we found that blocking or limiting iron uptake in immune cells could potentially ease up the symptoms of an asthma attack caused by allergens.

Immune cells that need iron

During an asthma attack, harmless allergens activate immune cells in your lungs called ILC2s. This causes them to multiply and release large amounts of cytokines – messengers that immune cells use to communicate – and to unwanted inflammation. The result is symptoms such as coughing and wheezing that make it feel like someone is squeezing your airways.

To assess the role iron plays in how ILC2s function in the lungs, we conducted a of experiments with ILC2s in the lab. We then confirmed our findings in mice with allergic asthma and in with different severities of asthma.

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First, we found that ILC2s use a protein called transferrin receptor 1, or TfR1, to take up iron. When we blocked this protein as the ILC2s were undergoing activation, the cells were unable to use iron and could no longer multiply and cause inflammation as well as they did before.

We then used a chemical called an iron chelator to prevent ILC2s from using any iron at all. Iron chelators are like superpowered magnets for iron and are used in medical treatments to manage conditions where there's too much iron in the body.

When we deprived ILC2s with an iron chelator, the cells had to change their metabolism and switch to a different way of getting energy, like trading in a car for a bicycle. The cells weren't as effective at causing inflammation in the lungs anymore.

Person with one hand to chest and other hand clutching an inhaler

An asthma attack can feel like someone is squeezing your airways.

Mariia Siurtukova/Moment via Getty Images

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Next, we limited cellular iron in mice with sensitive airways due to ILC2s. We did this in three different ways: by inhibiting TfR1, adding an iron chelator or inducing low overall iron levels using a synthetic protein called mini-hepcidin. Each of these methods helped reduce the mice's airway hyperreactivity – basically reducing the severity of their asthma symptoms.

Lastly, we looked at cells from patients with asthma. We noticed something interesting: the more TfR1 protein on their ILC2 cells, the worse their asthma symptoms. In other words, iron was playing a big role in how bad their asthma got. Blocking TfR1 and administering iron chelators both reduced ILC2 proliferation and cytokine production, suggesting that our findings in mice apply to human cells. This means we can move these findings from the lab to clinical trials as quickly as possible.

Iron therapy for asthma

Iron is like the conductor of an orchestra, instructing immune cells such as ILC2s how to behave during an asthma attack. Without enough iron, these cells can't cause as much trouble, which could mean fewer asthma symptoms.

Next, we're working on targeting a patient's immune cells during an asthma attack. If we can lower the amount of iron available to ILC2s without depleting overall iron levels in the body, this could mean a new therapy for asthma that tackles the root cause of the disease, not just the symptoms. Available treatments can control symptoms to keep patients alive, but they are not curing the disease. Iron-related therapies may offer a better solution for patients with asthma.

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Our discovery applies to more than just asthma. It could be a -changer for other diseases where ILC2s are involved, such as eczema and type 2 diabetes. Who knew iron could be such a big deal to your immune system?The Conversation

Benjamin Hurrell, Assistant Professor of Research in Molecular Microbiology and Immunology, University of Southern California and Omid Akbari, Professor of Molecular Microbiology and Immunology, University of Southern California

This article is republished from The Conversation under a Creative Commons license. Read the original article.

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Supreme Court kicks cases about tech companies’ First Amendment rights back to lower courts − but appears poised to block states from hampering online content moderation

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theconversation.com – Lynn Greenky, Professor Emeritus of Communication and Rhetorical Studies, Syracuse – 2024-07-01 15:26:42
How much power do social companies have over what users post?
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Lynn Greenky, Syracuse University

The U.S. Supreme Court has sent back to lower courts the about whether states can block social media companies such as Facebook and X, formerly Twitter, from regulating and controlling what users can post on their platforms.

Laws in Florida and Texas sought to impose restrictions on the internal policies and algorithms of social media platforms in ways that influence which posts will be promoted and spread widely and which will be made less visible or even .

In the unanimous decision, issued on July 1, 2024, the high court remanded the two cases, Moody v. NetChoice and NetChoice v. Paxton, to the 11th and 5th U.S. Circuit Courts of Appeals, respectively. The court admonished the lower courts for their failure to consider the full force of the laws' applications. It also warned the lower courts to consider the boundaries imposed by the Constitution against interference with private speech.

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Contrasting views of social media sites

In their arguments before the court in February 2024, the two sides described competing visions of how social media fits into the often overwhelming flood of information that defines modern digital society.

The states said the platforms were mere conduits of communication, or “speech hosts,” similar to legacy telephone companies that were required to carry all calls and prohibited from discriminating against users. The states said that the platforms should have to carry all posts from users without discrimination among them based on what they were saying.

The states argued that the content moderation rules the social media companies imposed were not examples of the platforms themselves speaking – or choosing not to speak. Rather, the states said, the rules affected the platforms' behavior and caused them to censor certain views by allowing them to determine whom to allow to speak on which topics, which is outside First Amendment protections.

By contrast, the social media platforms, represented by NetChoice, a tech industry trade group, argued that the platforms' guidelines about what is acceptable on their sites are protected by the First Amendment's guarantee of speech free from government interference. The companies say their platforms are not public forums that may be subject to government regulation but rather private services that can exercise their own editorial judgment about what does or does not appear on their sites.

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They argued that their policies were aspects of their own speech and that they should be to develop and implement guidelines about what is acceptable speech on their platforms based on their own First Amendment rights.

Here's what the First Amendment says and what it means.

A reframe by the Supreme Court

All the litigants – NetChoice, and Florida – framed the issue around the effect of the laws on the content moderation policies of the platforms, specifically whether the platforms were engaged in protected speech. The 11th U.S. Circuit Court of Appeals upheld a lower court preliminary injunction against the Florida law, holding the content moderation policies of the platforms were speech and the law was unconstitutional.

The 5th U.S. Circuit Court of Appeals came to the opposite conclusion and held that the platforms were not engaged in speech, but rather the platform's algorithms controlled platform behavior unprotected by the First Amendment. The 5th Circuit determined the behavior was censorship and reversed a lower court injunction against the Texas law.

The Supreme Court, however, reframed the inquiry. The court noted that the lower courts failed to consider the full range of activities the laws covered. Thus, while a First Amendment inquiry was in order, the decisions of the lower courts and the arguments by the parties were incomplete. The court added that neither the parties nor the lower courts engaged in a thorough analysis of whether and how the states' laws affected other elements of the platforms' products, such as Facebook's direct messaging applications, or even whether the laws have any impact on email providers or online marketplaces.

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The Supreme Court directed the lower courts to engage in a much more exacting analysis of the laws and their implications and provided some guidelines.

First Amendment principles

The court held that content moderation policies reflect the constitutionally protected editorial choices of the platforms, at least regarding what the court as “heartland applications” of the laws – such as Facebook's News Feed and YouTube's homepage.

The Supreme Court required the lower courts to consider two core constitutional principles of the First Amendment. One is that the amendment protects speakers from being compelled to communicate messages they would prefer to exclude. Editorial discretion by entities, social media companies, that compile and curate the speech of others is a protected First Amendment activity.

The other principle holds that the amendment precludes the government from controlling private speech, even for the purpose of balancing the marketplace of ideas. Neither nor federal government may manipulate that marketplace for the purposes of presenting a more balanced array of viewpoints.

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The court also affirmed that these principles apply to digital media in the same way they apply to traditional or legacy media.

In the 96-page opinion, Justice Elena Kagan wrote: “The First Amendment … does not go on leave when social media are involved.” For now, it appears the social media platforms will continue to control their content.The Conversation

Lynn Greenky, Professor Emeritus of Communication and Rhetorical Studies, Syracuse University

This article is republished from The Conversation under a Creative Commons license. Read the original article.

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Disability community has long wrestled with ‘helpful’ technologies – lessons for everyone in dealing with AI

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theconversation.com – Elaine Short, Assistant Professor of Computer Science, Tufts – 2024-07-01 07:19:34

A robotic arm helps a disabled person paint a picture.

Jenna Schad /Tufts University

Elaine Short, Tufts University

You might have heard that artificial intelligence is going to revolutionize everything, save the world and give everyone superhuman powers. Alternatively, you might have heard that it will take your job, make you lazy and stupid, and make the world a cyberpunk dystopia.

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Consider another way to look at AI: as an assistive technology – something that helps you function.

With that view, also consider a community of experts in giving and receiving assistance: the disability community. Many disabled people use technology extensively, both dedicated assistive technologies such as wheelchairs and general-use technologies such as smart home devices.

Equally, many disabled people professional and casual assistance from other people. And, despite stereotypes to the contrary, many disabled people regularly give assistance to the disabled and nondisabled people around them.

Disabled people are well experienced in receiving and giving social and technical assistance, which makes them a valuable source of insight into how everyone might relate to AI in the future. This potential is a key driver for my work as a disabled person and researcher in AI and robotics.

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Actively learning to live with help

While virtually everyone values independence, no one is fully independent. Each of us depends on others to grow our food, care for us when we are ill, give us advice and emotional , and us in thousands of interconnected ways. Being disabled means support needs that are outside what is typical and therefore those needs are much more visible. Because of this, the disability community has reckoned more explicitly with what it means to need help to live than most nondisabled people.

This disability community perspective can be invaluable in approaching new technologies that can assist both disabled and nondisabled people. You can't substitute pretending to be disabled for the experience of actually being disabled, but accessibility can benefit everyone.

The curb-cut effect – how technologies built for disabled people help everyone – has become a principle of good design.

This is sometimes called the curb-cut effect after the ways that putting a ramp in a curb to help a wheelchair user access the sidewalk also people with strollers, rolling suitcases and bicycles.

Partnering in assistance

You have probably had the experience of someone to help you without listening to what you actually need. For example, a parent or friend might “help” you clean and instead end up hiding everything you need.

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Disability advocates have long battled this type of well-meaning but intrusive assistance – for example, by putting spikes on wheelchair handles to keep people from pushing a person in a wheelchair without being asked to or advocating for services that keep the disabled person in control.

The disabled community instead offers a model of assistance as a collaborative effort. Applying this to AI can help to ensure that new AI tools support human autonomy rather than taking over.

A key goal of my lab's work is to develop AI-powered assistive robotics that treat the user as an equal partner. We have shown that this model is not just valuable, but inevitable. For example, most people find it difficult to use a joystick to move a robot arm: The joystick can only move from front to back and side to side, but the arm can move in almost as many ways as a human arm.

The author discusses her work on robots that are designed to help people.

To help, AI can predict what someone is planning to do with the robot and then move the robot accordingly. Previous research assumed that people would ignore this help, but we found that people quickly figured out that the system is doing something, actively worked to understand what it was doing and tried to work with the system to get it to do what they wanted.

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Most AI systems don't make this easy, but my lab's new approaches to AI empower people to influence robot behavior. We have shown that this results in better interactions in tasks that are creative, like painting. We also have begun to investigate how people can use this control to solve problems outside the ones the robots were designed for. For example, people can use a robot that is trained to carry a cup of to instead pour the water out to water their plants.

Training AI on human variability

The disability-centered perspective also raises concerns about the huge datasets that power AI. The very nature of data-driven AI is to look for common patterns. In general, the better-represented something is in the data, the better the model works.

If disability means having a body or mind outside what is typical, then disability means not being well-represented in the data. Whether it's AI systems designed to detect cheating on exams instead detecting students' disabilities or robots that fail to account for wheelchair users, disabled people's interactions with AI reveal how those systems are brittle.

One of my goals as an AI researcher is to make AI more responsive and adaptable to real human variation, especially in AI systems that learn directly from interacting with people. We have developed frameworks for testing how robust those AI systems are to real human teaching and explored how robots can learn better from human teachers even when those teachers change over time.

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Thinking of AI as an assistive technology, and learning from the disability community, can help to ensure that the AI systems of the future serve people's needs – with people in the driver's seat.The Conversation

Elaine Short, Assistant Professor of Computer Science, Tufts University

This article is republished from The Conversation under a Creative Commons license. Read the original article.

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How was popcorn discovered? An archaeologist on its likely appeal for people in the Americas millennia ago

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theconversation.com – Sean Rafferty, Professor of Anthropology, at Albany, University of New York – 2024-07-01 07:19:19

Could a spill by the cook fire have been popcorn's eureka moment?

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Sean Rafferty, University at Albany, State University of New York

Curious Kids is a series for children of all ages. If you have a question you'd like an expert to answer, send it to curiouskidsus@theconversation.com.

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How was popcorn discovered? – Kendra, age 11, Penn Yan, New York


You have to wonder how people originally figured out how to eat some foods that are beloved . The cassava plant is toxic if not carefully processed through multiple steps. Yogurt is basically old milk that's been around for a while and contaminated with bacteria. And who discovered that popcorn could be a toasty, tasty treat?

These kinds of food mysteries are pretty hard to solve. Archaeology depends on solid remains to figure out what happened in the past, especially for people who didn't use any sort of writing. Unfortunately, most stuff people traditionally used made from wood, animal materials or cloth decays pretty quickly, and archaeologists like me never find it.

We have lots of evidence of hard stuff, such as pottery and stone tools, but softer things – such as leftovers from a meal – are much harder to find. Sometimes we get lucky, if softer stuff is found in very dry places that preserve it. Also, if stuff gets burned, it can last a very long time.

Corn's ancestors

Luckily, corn – also called maize – has some hard parts, such as the kernel shell. They're the bits at the bottom of the popcorn bowl that get caught in your teeth. And since you have to heat maize to make it edible, sometimes it got burned, and archaeologists find evidence that way. Most interesting of all, some plants, including maize, contain tiny, rock-like fragments called phytoliths that can last for thousands of years.

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green plant stalks with reddish tendrils

The ancestor of maize was a grass called teosinte.

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Scientists are pretty sure they know how old maize is. We know maize was probably first farmed by Native Americans in what is now Mexico. Early farmers there domesticated maize from a kind of grass called teosinte.

Before farming, people would gather wild teosinte and eat the seeds, which contained a lot of starch, a carbohydrate like you'd find in bread or pasta. They would pick teosinte with the largest seeds and eventually started weeding and planting it. Over time, the wild plant developed into something like what we call maize today. You can tell maize from teosinte by its larger kernels.

There's evidence of maize farming from dry caves in Mexico as early as 9,000 years ago. From there, maize farming spread throughout North and South America.

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Popped corn, preserved food

Figuring out when people started making popcorn is harder. There are several types of maize, most of which will pop if heated, but one variety, actually called “popcorn,” makes the best popcorn. Scientists have discovered phytoliths from Peru, as well as burned kernels, of this type of “poppable” maize from as early as 6,700 years ago.

cobs of popcorn over popped kernels, one showing popping on the cob

Each popcorn kernel is a seed, ready to burst when heated.

Rick Madonik/Toronto Star via Getty Images

You can imagine that popping maize kernels was first discovered by . Some maize probably fell into a cooking fire, and whoever was nearby figured out that this was a handy new way of preparing the food. Popped maize would last a long time and was easy to make.

Ancient popcorn was probably not much like the snack you might munch at the theater today. There was probably no salt and definitely no butter, since there were no cows to milk in the Americas yet. It probably wasn't served hot and was likely pretty chewy with the version you're used to today.

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It's impossible to know exactly why or how popcorn was invented, but I would guess it was a clever way to preserve the edible starch in corn by getting rid of the little bit of inside each kernel that would make it more susceptible to spoiling. It's the heated water in the kernel escaping as steam that makes popcorn pop. The popped corn could then last a long time. What you may consider a tasty snack today probably started as a useful way of preserving and storing food.


Hello, curious kids! Do you have a question you'd like an expert to answer? Ask an adult to send your question to CuriousKidsUS@theconversation.com. Please tell us your name, age and the where you .

And since curiosity has no age limit – adults, let us know what you're wondering, too. We won't be able to answer every question, but we will do our best.The Conversation

Sean Rafferty, Professor of Anthropology, University at Albany, State University of New York

This article is republished from The Conversation under a Creative Commons license. Read the original article.

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