Mississippi Today
Animal tranquilizer emerging as latest deadly drug addiction mix


It’s the new silent killer in Mississippi.
Since 2020, the state has seen at least 27 overdose deaths from the animal tranquilizer xylazine, either alone or combined with fentanyl, said Col. Steven Maxwell, director of the Mississippi Bureau of Narcotics.
“It’s a crisis,” he said. “We’re not experiencing the crisis as much as places like Philadelphia, Atlanta, San Francisco and Los Angeles, but we are experiencing a crisis with regard to the lacing of fentanyl with other drugs, such as xylazine.”
The number of drug overdose deaths in Mississippi have nearly tripled since 2018, reaching 754 in 2021, according to the most recent state Department of Health statistics. The overdose deaths of Black Mississippians have catapulted from 37 to 165.
Nationwide, drug overdose deaths have doubled between 2015 and 2022, according to provisional data from the U.S. Centers for Disease Control and Prevention. Synthetic drugs, such as fentanyl, now make up more than two-thirds of those fatalities.
At HMP Global’s recent RX Summit in Atlanta, Dr. Rahul Gupta, director of the Office of National Drug Control Policy, announced that his office had designated the fentanyl-xylazine mix as an emerging drug threat.
“If you thought fentanyl was dangerous and deadly before, it has become even more lethal and destructive now,” he said. “We all must act.”
Xylazine is a non-opioid animal tranquilizer, typically administered by veterinarians to horses, cattle, deer, elk and moose.
Illicit use of the sedative has been skyrocketing in recent years. In 2015, the drug was involved in 2% of overdose deaths in Pennsylvania; now it’s involved in more than a fourth of those deaths.
The biggest growth has come in the South, which saw the highest increase in seizures of xylazine (193%) between 2020 and 2021, according to the Drug Enforcement Administration.
“Xylazine is not safe for human consumption,” Gupta said, “and it has potentially deadly consequences when used.”
Advocacy groups such as Drug Abuse Resistance Education have called xylazine “worse than fentanyl,” which is already involved in more deaths of Americans under 50 than any cause of death, including heart disease, cancer, homicide, suicide and other accidents, according to the DEA.
Because xylazine is designated for use in animals that may weigh significantly more than the average American, the effects on the human body are far greater, said William Lynch, a New Jersey clinical pharmacist who spoke at the RX Summit.
Xylazine not only slows breathing and the heart rate, but can cause the blood pressure to plummet, especially when used in combination with fentanyl, he said. In addition, users injecting the drug can develop severe skin ulcers that can resemble horrific burns, leading to skin grafts, possible amputation or even death.
When someone overdoses on fentanyl, emergency responders can use naloxone to try and revive that person. But when someone overdoses on a combination of fentanyl and xylazine, the naloxone has no effect on the xylazine, Lynch said. But it should still be given to reverse the effects of fentanyl, he said.
If naloxone does revive someone, “they have to go to the hospital,” because they could suffer from what he called “flashback pulmonary edema. They could possibly stop breathing and essentially drown in their sleep from fluid that accumulates in the lungs.”
On the streets, xylazine alone is known as “tranq,” or “tranq dope” when it’s mixed with fentanyl, he said. Experts say both dealers and drug users may mix the pair to prolong the opioid high.
Fentanyl has virtually replaced heroin on the streets because of its price tag, he said. While heroin costs about $23,000 a pound, according to a 2020 study, fentanyl is 10 times cheaper. Xylazine can run less than $10 a pound, according to a DEA report.
With regard to the suspected heroin seized in New Jersey, he said, 98% tested positive for fentanyl; only 2% had heroin alone. In New Jersey in 2022, of the 98% drug seizures that tested positive for fentanyl, 36% of those samples tested positive for xylazine.
In nearby Philadelphia, xylazine is supplanting fentanyl. In seizures there, Lynch said, there are 24 parts of xylazine to every one part of fentanyl, and the purity of the xylazine has gone up while the purity of the fentanyl has gone down.
Xylazine has long been easy to obtain, he said, and anyone could have had it delivered to their homes, not just veterinarians. To combat this, the FDA recently started tracking xylazine shipments.
Because it can be purchased cheaply in a powder or liquid form, dealers can mix this sedative with other drugs, which makes fatal overdoses a real possibility, he said.
Unlike fentanyl, xylazine isn’t illegal, which means there are no laws that give police the power to arrest.
Making xylazine a controlled substance would enable authorities to arrest those possessing or trafficking xylazine, Maxwell said. “It would be treated like any illicit drug.”

To attack this problem, governors in Ohio and Pennsylvania have declared xylazine a controlled substance. There is also a push in Congress to make it a controlled substance federally and also in some state legislatures, although not so far in Mississippi.
Asked if Gov. Tate Reeves supports the state making xylazine a controlled substance, Press Secretary Shelby Wilcher replied that there is currently legislation pending in Congress that would make the drug a Schedule 3 substance under federal schedules.
“The Office of the Governor works closely with the Mississippi Department of Health and Mississippi Department of Public Safety on an annual basis to update the state’s drug schedules,” she said. “Xylazine will certainly be part of the discussion.”
Lynch said one advantage to taking this step is veterinarians and their practices would be required to track the drug, just as they do with opioids and other controlled substances they use. “If you ever waste any of it,” he said, “you have to document the destruction with a witness.”
One concern about making xylazine a controlled substance is how it might affect veterinarians, who have used the sedative for half a century, said Bill Epperson, professor and head of the Department of Pathobiology and Population Medicine at Mississippi State University’s College of Veterinary Medicine.
The drug is typically used for pain relief and to “calm fractious animals,” he said. “There is not a good substitute for xylazine in large animal general practice.”
Given that veterinarians have used xylazine responsibly for decades, the drug should still be used “to support the legitimate practice of veterinary medicine,” he said. “We are strongly in favor of harsh penalties for those suppliers engaged in illicit activity.”
In March, Congress introduced the Combating Illicit Xylazine Act, which would make illicit use of xylazine fall under Schedule III penalties and allow legitimate veterinary use to continue. The American Veterinary Medical Association supports the bill.
Lynch warned that xylazine “is just the drug de jure,” and others are certain to follow. For example, he said, the synthetic opioid isotonitazene (known as “ISO”) “is approximately three times more potent than fentanyl and has already been seen in New Jersey and other parts of the country.”
This article first appeared on Mississippi Today and is republished here under a Creative Commons license.
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Mississippi Today
Speaker White wants Christmas tree projects bill included in special legislative session

House Speaker Jason White sent a terse letter to Lt. Gov. Delbert Hosemann on Thursday, saying House leaders are frustrated with Senate leaders refusing to discuss a “Christmas tree” bill spending millions on special projects across the state.
The letter signals the two Republican leaders remain far apart on setting an overall $7 billion state budget. Bickering between the GOP leaders led to a stalemate and lawmakers ending their regular 2025 session without setting a budget. Gov. Tate Reeves plans to call them back into special session before the new budget year starts July 1 to avoid a shutdown, but wants them to have a budget mostly worked out before he does so.
White’s letter to Hosemann, which contains words in all capital letters that are underlined and italicized, said that the House wants to spend cash reserves on projects for state agencies, local communities, universities, colleges, and the Mississippi Department of Transportation.
“We believe the Senate position to NOT fund any local infrastructure projects is unreasonable,” White wrote.
The speaker in his letter noted that he and Hosemann had a meeting with the governor on Tuesday. Reeves, according to the letter, advised the two legislative leaders that if they couldn’t reach an agreement on how to disburse the surplus money, referred to as capital expense money, they should not spend any of it on infrastructure.
A spokesperson for Hosemann said the lieutenant governor has not yet reviewed the letter, and he was out of the office on Thursday working with a state agency.
“He is attending Good Friday services today, and will address any correspondence after the celebration of Easter,” the spokesperson said.
Hosemann has recently said the Legislature should set an austere budget in light of federal spending cuts coming from the Trump administration, and because state lawmakers this year passed a measure to eliminate the state income tax, the source of nearly a third of the state’s operating revenue.
Lawmakers spend capital expense money for multiple purposes, but the bulk of it — typically $200 million to $400 million a year — goes toward local projects, known as the Christmas Tree bill. Lawmakers jockey for a share of the spending for their home districts, in a process that has been called a political spoils system — areas with the most powerful lawmakers often get the largest share, not areas with the most needs. Legislative leaders often use the projects bill as either a carrot or stick to garner votes from rank and file legislators on other issues.
A Mississippi Today investigation last year revealed House Ways and Means Chairman Trey Lamar, a Republican from Sentobia, has steered tens of millions of dollars in Christmas tree spending to his district, including money to rebuild a road that runs by his north Mississippi home, renovate a nearby private country club golf course and to rebuild a tiny cul-de-sac that runs by a home he has in Jackson.
There is little oversight on how these funds are spent, and there is no requirement that lawmakers disburse the money in an equal manner or based on communities’ needs.
In the past, lawmakers borrowed money for Christmas tree bills. But state coffers have been full in recent years largely from federal pandemic aid spending, so the state has been spending its excess cash. White in his letter said the state has “ample funds” for a special projects bill.
“We, in the House, would like to sit down and have an agreement with our Senate counterparts on state agency Capital Expenditure spending AND local projects spending,” White wrote. “It is extremely important to our agencies and local governments. The ball is in your court, and the House awaits your response.”
This article first appeared on Mississippi Today and is republished here under a Creative Commons Attribution-NoDerivatives 4.0 International License.
Mississippi Today
Advocate: Election is the chance for Jackson to finally launch in the spirit of Blue Origin

Editor’s note: This essay is part of Mississippi Today Ideas, a platform for thoughtful Mississippians to share fact-based ideas about our state’s past, present and future. You can read more about the section here.
As the world recently watched the successful return of Blue Origin’s historic all-women crew from space, Jackson stands grounded. The city is still grappling with problems that no rocket can solve.
But the spirit of that mission — unity, courage and collective effort — can be applied right here in our capital city. Instead of launching away, it is time to launch together toward a more just, functioning and thriving Jackson.
The upcoming mayoral runoff election on April 22 provides such an opportunity, not just for a new administration, but for a new mindset. This isn’t about endorsements. It’s about engagement.
It’s a moment for the people of Jackson and Hinds County to take a long, honest look at ourselves and ask if we have shown up for our city and worked with elected officials, instead of remaining at odds with them.
It is time to vote again — this time with deeper understanding and shared responsibility. Jackson is in crisis — and crisis won’t wait.
According to the U.S. Census projections, Jackson is the fastest-shrinking city in the United States, losing nearly 4,000 residents in a single year. That kind of loss isn’t just about numbers. It’s about hope, resources, and people’s decision to give up rather than dig in.
Add to that the long-standing issues: a crippled water system, public safety concerns, economic decline and a sense of division that often pits neighbor against neighbor, party against party and race against race.
Mayor Chokwe Antar Lumumba has led through these storms, facing criticism for his handling of the water crisis, staffing issues and infrastructure delays. But did officials from the city, the county and the state truly collaborate with him or did they stand at a distance, waiting to assign blame?
On the flip side, his runoff opponent, state Sen. John Horhn, who has served for more than three decades, is now seeking to lead the very city he has represented from the Capitol. Voters should examine his legislative record and ask whether he used his influence to help stabilize the administration or only to position himself for this moment.
Blaming politicians is easy. Building cities is hard. And yet that is exactly what’s needed. Jackson’s future will not be secured by a mayor alone. It will take so many of Jackson’s residents — voters, business owners, faith leaders, students, retirees, parents and young people — to move this city forward. That’s the liftoff we need.
It is time to imagine Jackson as a capital city where clean, safe drinking water flows to every home — not just after lawsuits or emergencies, but through proactive maintenance and funding from city, state and federal partnerships. The involvement of the U.S. Environmental Protection Agency in the effort to improve the water system gives the city leverage.
Public safety must be a guarantee and includes prevention, not just response, with funding for community-based violence interruption programs, trauma services, youth job programs and reentry support. Other cities have done this and it’s working.
Education and workforce development are real priorities, preparing young people not just for diplomas but for meaningful careers. That means investing in public schools and in partnerships with HBCUs, trade programs and businesses rooted right here.
Additionally, city services — from trash collection to pothole repair — must be reliable, transparent and equitable, regardless of zip code or income. Seamless governance is possible when everyone is at the table.
Yes, democracy works because people show up. Not just to vote once, but to attend city council meetings, serve on boards, hold leaders accountable and help shape decisions about where resources go.
This election isn’t just about who gets the title of mayor. It’s about whether Jackson gets another chance at becoming the capital city Mississippi deserves — a place that leads by example and doesn’t lag behind.
The successful Blue Origin mission didn’t happen by chance. It took coordinated effort, diverse expertise and belief in what was possible. The same is true for this city.
We are not launching into space. But we can launch a new era marked by cooperation over conflict, and by sustained civic action over short-term outrage.
On April 22, go vote. Vote not just for a person, but for a path forward because Jackson deserves liftoff. It starts with us.
Pauline Rogers is a longtime advocate for criminal justice reform and the founder of the RECH Foundation, an organization dedicated to supporting formerly incarcerated individuals as they reintegrate into society. She is a Transformative Justice Fellow through The OpEd Project Public Voices Fellowship.
This article first appeared on Mississippi Today and is republished here under a Creative Commons Attribution-NoDerivatives 4.0 International License.
Mississippi Today
On this day in 1959, students marched for integrated schools

April 18, 1959

About 26,000 students took part in the Youth March for Integrated Schools in Washington, D.C. They heard speeches by Martin Luther King Jr., A. Phillip Randolph and NAACP leader Roy Wilkins.
In advance of the march, false accusations were made that Communists had infiltrated the group. In response, the civil rights leaders put out a statement: “The sponsors of the March have not invited Communists or communist organizations. Nor have they invited members of the Ku Klux Klan or the White Citizens’ Council. We do not want the participation of these groups, nor of individuals or other organizations holding similar views.”
After the march, a delegation of students went to present their demands to President Eisenhower, only to be told by his deputy assistant that “the president is just as anxious as they are to see an America where discrimination does not exist, where equality of opportunity is available to all.”
King praised the students, saying, “In your great movement to organize a march for integrated schools, you have awakened on hundreds of campuses throughout the land a new spirit of social inquiry to the benefit of all Americans.”
This article first appeared on Mississippi Today and is republished here under a Creative Commons Attribution-NoDerivatives 4.0 International License.
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