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Alcohol and drugs rewire your brain by changing how your genes work – research is investigating how to counteract addiction’s effects

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Alcohol and drugs rewire your brain by changing how your genes work – research is investigating how to counteract addiction’s effects

Alcohol and other drugs can overpower the reward pathways of the brain.
Simona Dumitru/Moment via Getty Images

Karla Kaun, Brown University

Many people are wired to seek and respond to rewards. Your brain interprets food as rewarding when you are hungry and as rewarding when you are thirsty. But addictive substances like alcohol and drugs of abuse can overwhelm the natural reward pathways in your brain, resulting in intolerable cravings and reduced impulse control.

A popular misconception is that addiction is a result of low willpower. But an explosion of knowledge and technology in the field of molecular genetics has changed our basic understanding of addiction drastically over the past decade. The general consensus among scientists and professionals is that there is a strong neurobiological and genetic basis for addiction.

As a behavioral neurogeneticist leading a team investigating the molecular mechanisms of addiction, I combine neuroscience with genetics to understand how alcohol and drugs influence the brain. In the past decade, I have seen changes in our understanding of the molecular mechanisms of addiction, largely due to a better understanding of how genes are dynamically regulated in the brain. New ways of thinking about how addictions form have the potential to change how we approach treatment.

Alcohol and drugs affect brain gene activity

Each of your brain cells has your genetic code stored in long strands of DNA. For all that DNA to fit into a cell, it needs to be packed tightly. This is achieved by winding the DNA around “spools” of protein called histones. where DNA is unwound contain active genes coding for proteins that serve important functions within the cell.

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When gene activity changes, the proteins your cells produce also change. Such changes can range from a single neuronal connection in your brain to how you behave. This genetic choreography suggests that while your genes affect how your brain develops, which genes are turned on or off when you are learning new things is dynamic and adapts to suit your daily needs.

Recent data from animal models suggests that alcohol and drugs of abuse directly influence changes in gene expression in areas of the brain that memory and reward responses.

Diagram magnifying the nucleus of a neuron, showing spirals of DNA wound around bundles of protein
Within each neuron in the brain, how tightly DNA is wound around or bound to histones and other proteins determines which genes are expressed and which proteins are produced.
Karla Kaun and Vinald Francis, CC BY-ND

There are many ways addictive substances can change gene expression. They can alter which proteins bind to DNA to turn genes on and off and which segments of DNA are unwound. They can change the of how DNA is read and translated into proteins, as well as alter the proteins that determine how cells use energy to function.

For example, alcohol can cause an alternative form of a gene to be expressed in the memory circuits in flies and people, resulting in changes in dopamine receptors and transcription factors involved in reward signaling and neuronal function. Similarly, cocaine can cause an alternative form of a gene to be expressed in the reward centers of mice, leading them to seek out more cocaine.

Exactly how these drugs cause changes in gene regulation is unknown. However, a direct link between alcohol consumption and changes in gene expression in mice provides a clue. A byproduct of alcohol being broken down in the liver called acetate can cross the blood-brain barrier and unwind DNA from histones in mouse memory circuits.

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Alcohol, nicotine, cocaine and opioids also all activate important signaling pathways that are central regulators of metabolism. This suggests they can also affect many aspects of neuronal function and consequently affect which genes are expressed.

Changing brain gene activity with lifestyle

How addictive substances change cell function is complex. The version of a gene you’re born with can be modified in many ways before it becomes a functional protein, exposure to alcohol and drugs. Rather than discouraging researchers, this complexity is empowering because it provides evidence that changes to gene expression in your brain aren’t permanent. They can also be altered by medications and lifestyle choices.

Many commonly prescribed medications for mental disorders also affect gene expression. Antidepressants and mood stabilizers can change how DNA is modified and which genes are expressed. For example, a commonly prescribed drug for depression called escitalopram affects how tightly wound DNA is and can change the expression of genes important to brain plasticity.

Additionally, mRNA-based therapies can specifically change which genes are expressed to treat diseases like cancer. In the future, we may discover similar therapies for alcohol and substance use disorder. These treatments could potentially target important signaling pathways linked to addiction, altering how brain circuits function and how alcohol and drugs affect them.

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Close-up of person sitting with crossed legs on a yoga mat, hands resting on knees with pointer finger touching thumb
Exercise and other lifestyle choices can affect gene regulation.
Afriandi/Moment via Getty Images

Lifestyle choices can also affect gene expression in your brain, though researchers don’t yet know whether they can alter the changes induced by addictive substances.

Like alcohol and drugs, dietary changes can affect gene expression in many ways. In flies, a high sugar diet can reprogram the ability to taste sweetness by tapping into a gene expression network involved in .

Intensive meditation, even after only one day, can also affect gene regulation in your brain through similar mechanisms. Attending a monthlong meditation retreat reduces the expression of genes that affect inflammation, and experienced meditators can reduce inflammatory genes after just one day of intensive meditation.

Work in animal models has also shown that exercise changes gene expression by altering both histones and the molecular tags directly attached to DNA. This increases the activity of genes important to the activity and plasticity of neurons, supporting the idea that exercise improves learning and memory and can decrease the risk of dementia.

From Dry January and beyond, many factors can have profound effects on your brain biology. Taking steps to reduce consumption of alcohol and drugs and picking up healthy lifestyle practices can help stabilize and bring long-lasting for your physical and mental health.The Conversation

Karla Kaun, Associate Professor of Neuroscience, Brown University

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The Conversation

Will your phone one day let you smell as well as see and hear what’s on the other end of a call?

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theconversation.com – Jian Liu, Assistant Professor of Electrical Engineering and Computer Science, of Tennessee – 2024-09-16 07:27:05

Phones that transmit odors seem like a great idea, but careful what you wish for!

Teo Mahatmana/iStock via Getty Images

Jian Liu, University of Tennessee

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Curious Kids is a for of all ages. If you have a question you’d like an expert to answer, send it to curiouskidsus@theconversation.com.


Is it possible to make a phone through which we can smell, like we can hear and see? – Muneeba K., age 10, Pakistan


Imagine this: You pick up your phone for a call with a friend. Not only can you see their face and hear their voice, but you can also smell the cookies they just baked. It sounds like something out of a science fiction movie, but could it actually happen?

I’m a computer scientist who studies how machines sense the world.

What phones do now

When you listen to music or to someone on your phone, you can hear the sound through the built-in speakers. These speakers convert digital signals into physical vibrations using a tiny component called a diaphragm. Your ears sense those vibrations as sound waves.

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Your phone also has a screen that displays images and . The screen uses tiny dots known as pixels that consist of three primary colors: red, green and blue. By mixing these colors in different ways, your phone can show you everything from beautiful beach scenes to cute puppies.

Smelling with phones

Now how about the sense of smell? Smells are created by tiny particles called molecules that float through the and reach your nose. Your nose then sends signals to your brain, which identifies the smell.

So, could your phone send these smell molecules to you? Scientists are working on it. Think about how your phone screen works. It doesn’t have every color in the world stored inside it. Instead, it uses just three colors to create millions of different hues and shades.

How your sense of smell works.

Now imagine something similar for smells. Scientists are developing digital scent technology that uses a small number of different cartridges, each containing a specific scent. Just like how pixels mix three colors to create images, these scent cartridges could mix to create different smells.

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Just like images on your phone are made of digital codes that represent combinations of pixels, smells produced by a future phone could be created using digital codes. Each smell could have a specific recipe made up of different amounts of the ingredients in the cartridges.

When you a digital scent code, your phone could mix tiny amounts of the different scents from the cartridges to create the desired smell. This mix would then be released through a small vent on the phone, allowing you to smell it. With just a few cartridges, your phone could potentially create a huge variety of smells, much like how red, green and blue pixels can create countless colors.

Researchers and companies are already working on digital odor makers like this.

The challenges to making smell phones

Creating a phone that can produce smells involves several challenges. One is designing a system that can produce thousands of different smells using only a few cartridges. Another is how to control how strong a scent should be and how long a phone should emit it. And phones will also need to sense odors near them and convert those to digital codes so your friends’ phones can send smells to you.

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The cartridges should also be easy to refill, and the chemicals in them be safe to breathe. These hurdles make it a tricky but exciting area of research.

An odiferous future

Even though we’re not there yet, scientists and engineers are working hard to make smell phones a reality. Maybe one day you’ll be able to not only see and hear your friend’s birthday party over the phone, but also smell the candles they blew out!


Hello, curious kids! Do you have a question you’d like an expert to answer? Ask an adult to send your question to CuriousKidsUS@theconversation.com. Please tell us your name, age and the city where you .

And since curiosity has no age limit – adults, let us know what you’re wondering, too. We won’t be able to answer every question, but we will do our best.The Conversation

Jian Liu, Assistant Professor of Electrical Engineering and Computer Science, University of Tennessee

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a double shot of US history

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theconversation.com – Kyle G. Volk, Professor of History, University of Montana – 2024-09-16 07:28:46

a beer in Raceland, La.

Russell Lee for Farm Security Administration/WPA

Kyle G. Volk, University of Montana

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Text saying: Uncommon Courses, from The Conversation

Uncommon Courses is an occasional from The Conversation U.S. highlighting unconventional approaches to teaching.

Title of course:

“Intoxication Nation: Alcohol in American History”

What prompted the idea for the course?

I wanted to get about studying the past by learning about something that is very much a part of their own lives.

Alcohol – somewhat surprisingly to me at first – featured prominently in my own research on minority rights and U.S. democracy in the mid-19th century. As a result, I knew quite a bit about the temperance movement and conflicts over prohibition during that period. Designing this course me to broaden my expertise.

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What does the course explore?

Prohibition is a must-do subject. Students expect it. But I several hundred years of history: from the 17th-century invention of rum – as a byproduct of sugar produced by enslaved people – to the rise of craft beer and craft spirits in the 21st century.

A faded poster with an illustration of a person about to smash a huge bottle of alcohol, and the message 'Close the saloons' at the top.

A temperance poster from the World War I era.

Office of Naval Records and Library via National Archives Catalog

Along the way, I’m thrilled when students get excited about details that allow them to taste a more complicated historical cocktail. For example, they learn why white women’s production of hard cider was crucial to the survival of colonial Virginia. The short answer: Potable was in short supply, alcoholic drinks were far healthier, and white men – and their indentured and enslaved workforce – were busy raising tobacco. It fell to women to turn fruit into salvation.

Why is this course relevant now?

Alcohol remains a big and almost inescapable part of American society. But of late, Americans have been drinking differently – and thinking about drinking differently.

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Examples abound. Alcohol producers, we learn, now face competition from legalized weed. Drinking l evels rose during the COVID-19 pandemic, yet interest is declining among Gen Zers. The “wine mom” culture that brought some mothers together now faces mounting criticism.

And, of course, there’s the never-ending debate about the health benefits and risks of alcohol. Of late, the risks seem to be dominating headlines.

What’s a critical lesson from the course?

Alcohol has been a highly controversial, central aspect of the American experience, shaping virtually all sectors of our society – political and constitutional, business and economic, social and cultural.

What materials does the course feature?

What will the course prepare students to do?

Like any history course, this one aims to develop student’s analytical, written, research and verbal skills. In lots of ways, the topic is just a tool to get students to grow their brains. But I also seek to grow students’ critical awareness of the place of alcohol in their own lives. The course has also informed students’ paths after graduation – including some who wound up working in the alcohol industry or recovery organizations.The Conversation

Kyle G. Volk, Professor of History, University of Montana

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Sunflowers make small moves to maximize their Sun exposure − physicists can model them to predict how they grow

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theconversation.com – Chantal Nguyen, Postdoctoral Associate at the BioFrontiers Institute, of Colorado Boulder – 2024-09-13 07:31:40

Sunflowers use tiny movements to follow the Sun’s path throughout the day.

AP Photo/Charlie Riedel

Chantal Nguyen, University of Colorado Boulder

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Most of us aren’t spending our days watching our houseplants grow. We see their signs of only occasionally – a new leaf unfurled, a stem leaning toward the window.

But in the summer of 1863, Charles Darwin lay ill in bed, with nothing to do but watch his plants so closely that he could detect their small movements to and fro. The tendrils from his cucumber plants swept in circles until they encountered a stick, which they proceeded to twine around.

“I am getting very much amused by my tendrils,” he wrote.

This amusement blossomed into a decadeslong fascination with the little-noticed world of plant movements. He compiled his detailed observations and experiments in a 1880 book called “The Power of Movement in Plants.”

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A zig-zagging line showing the movement of a leaf.

A diagram tracking the circumnutation of a leaf over three days.

Charles Darwin

In one study, he traced the motion of a carnation leaf every few hours over the course of three days, revealing an irregular looping, jagged path. The swoops of cucumber tendrils and the zags of carnation leaves are examples of inherent, ubiquitous plant movements called circumnutations – from the Latin circum, meaning circle, and nutare, meaning to nod.

Circumnutations vary in size, regularity and timescale across plant species. But their exact function remains unclear.

I’m a physicist interested in understanding collective behavior in living . Like Darwin, I’m captivated by circumnutations, since they may underlie more complex phenomena in groups of plants.

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Sunflower patterns

A 2017 study revealed a fascinating observation that got my colleagues and me wondering about the role circumnutations could play in plant growth patterns. In this study, researchers found that sunflowers grown in a dense row naturally formed a near-perfect zigzag pattern, with each plant leaning away from the row in alternating directions.

This pattern the plants to avoid shade from their neighbors and maximize their exposure to sunlight. These sunflowers flourished.

Researchers then planted some plants at the same density but constrained them so that they could grow only upright without leaning. These constrained plants produced less oil than the plants that could lean and get the maximum amount of sun.

While farmers can’t grow their sunflowers quite this close together due to the potential for disease spread, in the future they may be able to use these patterns to up with new planting strategies.

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Self-organization and randomness

This spontaneous pattern formation is a neat example of self-organization in nature. Self-organization refers to when initially disordered systems, such as a jungle of plants or a swarm of bees, achieve order without anything controlling them. Order emerges from the interactions between individual members of the system and their interactions with the .

Somewhat counterintuitively, noise – also called randomness – facilitates self-organization. Consider a colony of ants.

Ants secrete pheromones behind them as they crawl toward a food source. Other ants find this food source by the pheromone trails, and they further reinforce the trail they took by secreting their own pheromones in turn. Over time, the ants converge on the best path to the food, and a single trail prevails.

But if a shorter path were to become possible, the ants would not necessarily find this path just by following the existing trail.

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If a few ants were to randomly deviate from the trail, though, they might stumble onto the shorter path and create a new trail. So this randomness injects a spontaneous change into the ants’ system that allows them to explore alternative scenarios.

Eventually, more ants would follow the new trail, and soon the shorter path would prevail. This randomness helps the ants adapt to changes in the environment, as a few ants spontaneously seek out more direct ways to their food source.

A group of honeybees spread out standing on honeycomb.

Beehives are an example of self-organization in nature.

Martin Ruegner/Stone via Getty Images

In biology, self-organized systems can be found at a range of scales, from the patterns of proteins inside cells to the socially complex colonies of honeybees that collectively build nests and forage for nectar.

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Randomness in sunflower self-organization

So, could random, irregular circumnutations underpin the sunflowers’ self-organization?

My colleagues and I set out to explore this question by following the growth of young sunflowers we planted in the lab. Using cameras that imaged the plants every five minutes, we tracked the movement of the plants to see their circumnutatory paths.

We saw some loops and spirals, and lots of jagged movements. These ultimately appeared largely random, much like Darwin’s carnation. But when we placed the plants together in rows, they began to move away from one another, forming the same zigzag configurations that we’d seen in the previous study.

Five plants and a diagram showing loops and jagged lines that represent small movements made by the plants.

Tracking the circumnutations made by young sunflower plants.

Chantal Nguyen

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We analyzed the plants’ circumnutations and found that at any given time, the direction of the plant’s motion appeared completely independent of how it was moving about half an hour earlier. If you measured a plant’s motion once every 30 minutes, it would appear to be moving in a completely random way.

We also measured how much the plant’s leaves grew over the course of two weeks. By putting all of these results together, we sketched a picture of how a plant moved and grew on its own. This information allowed us to computationally model a sunflower and simulate how it behaves over the course of its growth.

A sunflower model

We modeled each plant simply as a circular crown on a stem, with the crown expanding according to the growth rate we measured experimentally. The simulated plant moved in a completely random way, taking a “step” every half hour.

We created the model sunflowers with circumnutations of lower or higher intensity by tweaking the step sizes. At one end of the spectrum, sunflowers were much more likely to take tiny steps than big ones, leading to slow, minimal movement on average. At the other end were sunflowers that are equally as likely to take large steps as small steps, resulting in highly irregular movement. The real sunflowers we observed in our experiment were somewhere in the middle.

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Plants require light to grow and have evolved the ability to detect shade and alter the direction of their growth in response.

We wanted our model sunflowers to do the same thing. So, we made it so that two plants that get too close to each other’s shade begin to lean away in opposite directions.

Finally, we wanted to see whether we could replicate the zigzag pattern we’d observed with the real sunflowers in our model.

First, we set the model sunflowers to make small circumnutations. Their shade avoidance responses pushed them away from each other, but that wasn’t enough to produce the zigzag – the model plants stayed stuck in a line. In physics, we would call this a “frustrated” system.

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Then, we set the plants to make large circumnutations. The plants started moving in random patterns that often brought the plants closer together rather than farther apart. Again, no zigzag pattern like we’d seen in the field.

But when we set the model plants to make moderately large movements, similar to our experimental measurements, the plants could self-organize into a zigzag pattern that gave each sunflower optimal exposure to light.

So, we showed that these random, irregular movements helped the plants explore their surroundings to find desirable arrangements that benefited their growth.

Plants are much more dynamic than people give them credit for. By taking the time to follow them, scientists and farmers can unlock their secrets and use plants’ movement to their advantage.The Conversation

Chantal Nguyen, Postdoctoral Associate at the BioFrontiers Institute, University of Colorado Boulder

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