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Tiny laboratories that fit in your hand can rapidly identify pathogens using electricity

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theconversation.com – Blanca H. Lapizco-Encinas, Professor of Biomedical Engineering, Rochester Institute of Technology – 2024-11-26 07:34:00

Microfluidics makes use of tiny channels to speed up analyses of biomolecules such as DNA and proteins.

Thom Leach/Science Photo Library via Getty Images

Blanca H. Lapizco-Encinas, Rochester Institute of Technology

When you think of electric fields, you likely think of electricity – the stuff that makes modern life possible by powering everything from household appliances to cellphones. Researchers have been studying the principles of electricity since the 1600s. Benjamin Franklin, famous for his kite experiment, demonstrated that lightning was indeed electrical.

Electricity has also enabled major advances in biology. A technique called electrophoresis allows scientists to analyze the molecules of life – DNA and proteins – by separating them by their electrical charge. Electrophoresis is not only commonly taught in high school biology, but it’s also a workhorse of many clinical and research laboratories, including mine.

I am a biomedical engineering professor who works with miniaturized electrophoretic systems. Together, my students and I develop portable versions of these devices that rapidly detect pathogens and help researchers fight against them.

Electrophoresis is a staple in high school classrooms and research labs alike.

What is electrophoresis?

Researchers discovered electrophoresis in the 19th century by applying an electric voltage to clay particles and observing how they migrated through a layer of sand. After further advances during the 20th century, electrophoresis became standard in laboratories.

To understand how electrophoresis works, we first need to explain electric fields. These are invisible forces that electrically charged particles, such as protons and electrons, exert on each other. A particle with a positive electrical charge, for example, would be attracted toward a particle with a negative charge. The law of “opposites attract” applies here. Molecules can also have a charge; whether it’s more positive or negative depends on the types of atoms that make it up.

In electrophoresis, an electric field is generated between two electrodes connected to a power supply. One electrode has a positive charge and the other has a negative charge. They are positioned on opposite sides of a container filled with water and a little bit of salt, which can conduct electricity.

When charged molecules such as DNA and proteins are present in the water, the electrodes create a force field between them that pushes the charged particles toward the oppositely charged electrode. This process is called electrophoretic migration.

Illustration of an electrophoresis system, where negatively charged pathogens migrate towards the positively charged electrode

Pathogens have distinct electrical charges and can be separated by measuring how quickly they move through electrophoresis.

Blanca H. Lapizco-Encinas, CC BY-SA

Researchers like electrophoresis because it is fast and flexible. Electrophoresis can help analyze distinct types of particles, from molecules to microbes. Further, electrophoresis can be carried out with materials such as paper, gels and thin tubes.

In 1972, physicist Stanislav Dukhin and his colleagues observed another type of electrophoretic migration called nonlinear electrophoresis that could separate particles not only by their electrical charge but also by their size and shape.

Electric fields and pathogens

Further advancements in electrophoresis have made it a useful tool to fight pathogens. In particular, the microfluidics revolution made possible the tiny laboratories that allow researchers to rapidly detect pathogens.

In 1999, researchers found that these tiny electrophoresis systems could also separate intact pathogens by differences in their electrical charge. They placed a mixture of several types of bacteria in a very thin glass capillary that was then exposed to an electric field. Some bacteria exited the device faster than others due to their distinct electrical charges, making it possible to separate the microbes by type. Measuring their migration speeds allowed scientists to identify each species of bacteria present in the sample through a process that took less than 20 minutes.

Microfluidics improved this process even further. Microfluidic devices are small enough to fit in the palm of your hand. Their miniature size allows them to perform analyses much faster than conventional laboratory equipment because particles don’t need to travel that far through the device to be analyzed. This means the molecules or pathogens researchers are looking for are more easily detected and less likely to be lost during analysis.

Clear rectangular piece of glass around five centimeters long, with two blue lines intersecting like a cross with wells at each point

This is an example of a microfluidic electrophoresis device the author uses in her lab.

Alaleh Vaghef-Koodehi, CC BY-SA

For example, samples analyzed using conventional electrophoresis systems would need to travel through capillary tubes that are about 11 to 31 inches (30 to 80 centimeters) long. These can take 40 to 50 minutes to process and are not portable. In comparison, samples analyzed with tiny electrophoresis systems migrate through microchannels that are only 0.4 to 2 inches (1 to 5 centimeters) long. This translates to small, portable devices with analysis times of about two to three minutes.

Nonlinear electrophoresis has enabled more powerful devices by allowing researchers to separate and detect pathogens by their size and shape. My lab colleagues and I showed that combining nonlinear electrophoresis with microfluidics can not only separate distinct types of bacterial cells but also live and dead bacterial cells.

Tiny electrophoresis systems in medicine

Microfluidic electrophoresis has the potential to be useful across industries. Primarily, these small systems can replace conventional analysis methods with faster results, greater convenience and lower cost.

For example, when testing the efficacy of antibiotics, these tiny devices could help researchers quickly tell whether pathogens are dead after treatment. It could also help doctors decide which drug is most appropriate for a patient by quickly distinguishing between normal bacteria and antibiotic-resistant bacteria.

My lab is also working on developing microelectrophoresis systems for purifying bacteriophage viruses that can be used to treat bacterial infections.

With further development, the power of electric fields and microfluidics can speed up how researchers detect and fight pathogens.The Conversation

Blanca H. Lapizco-Encinas, Professor of Biomedical Engineering, Rochester Institute of Technology

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Taxpayers spend 22% more per patient to support Medicare Advantage – the private alternative to Medicare that promised to cost less

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theconversation.com – Grace McCormack, Postdoctoral researcher of Health Policy and Economics, University of Southern California – 2024-11-26 07:38:00

Grace McCormack, University of Southern California and Erin Duffy, University of Southern California

Medicare Advantage – the commercial alternative to traditional Medicare – is drawing down federal health care funds, costing taxpayers an extra 22% per enrollee to the tune of US$83 billion a year.

Medicare Advantage, also known as Part C, was supposed to save the government money. The competition among private insurance companies, and with traditional Medicare, to manage patient care was meant to give insurance companies an incentive to find efficiencies. Instead, the program’s payment rules overpay insurance companies on the taxpayer’s dime.

We are health care policy experts who study Medicare, including how the structure of the Medicare payment system is, in the case of Medicare Advantage, working against taxpayers.

Medicare beneficiaries choose an insurance plan when they turn 65. Younger people can also become eligible for Medicare due to chronic conditions or disabilities. Beneficiaries have a variety of options, including the traditional Medicare program administered by the U.S. government, Medigap supplements to that program administered by private companies, and all-in-one Medicare Advantage plans administered by private companies.

Commercial Medicare Advantage plans are increasingly popular – over half of Medicare beneficiaries are enrolled in them, and this share continues to grow. People are attracted to these plans for their extra benefits and out-of-pocket spending limits. But due to a loophole in most states, enrolling in or switching to Medicare Advantage is effectively a one-way street. The Senate Finance Committee has also found that some plans have used deceptive, aggressive and potentially harmful sales and marketing tactics to increase enrollment.

Baked into the plan

Researchers have found that the overpayment to Medicare Advantage companies, which has grown over time, was, intentionally or not, baked into the Medicare Advantage payment system. Medicare Advantage plans are paid more for enrolling people who seem sicker, because these people typically use more care and so would be more expensive to cover in traditional Medicare.

However, differences in how people’s illnesses are recorded by Medicare Advantage plans causes enrollees to seem sicker and costlier on paper than they are in real life. This issue, alongside other adjustments to payments, leads to overpayment with taxpayer dollars to insurance companies.

Some of this extra money is spent to lower cost sharing, lower prescription drug premiums and increase supplemental benefits like vision and dental care. Though Medicare Advantage enrollees may like these benefits, funding them this way is expensive. For every extra dollar that taxpayers pay to Medicare Advantage companies, only roughly 50 to 60 cents goes to beneficiaries in the form of lower premiums or extra benefits.

As Medicare Advantage becomes increasingly expensive, the Medicare program continues to face funding challenges.

In our view, in order for Medicare to survive long term, Medicare Advantage reform is needed. The way the government pays the private insurers who administer Medicare Advantage plans, which may seem like a black box, is key to why the government overpays Medicare Advantage plans relative to traditional Medicare.

Paying Medicare Advantage

Private plans have been a part of the Medicare system since 1966 and have been paid through several different systems. They garnered only a very small share of enrollment until 2006.

The current Medicare Advantage payment system, implemented in 2006 and heavily reformed by the Affordable Care Act in 2010, had two policy goals. It was designed to encourage private plans to offer the same or better coverage than traditional Medicare at equal or lesser cost. And, to make sure beneficiaries would have multiple Medicare Advantage plans to choose from, the system was also designed to be profitable enough for insurers to entice them to offer multiple plans throughout the country.

To accomplish this, Medicare established benchmark estimates for each county. This benchmark calculation begins with an estimate of what the government-administered traditional Medicare plan would spend on the average county resident. This value is adjusted based on several factors, including enrollee location and plan quality ratings, to give each plan its own benchmark.

Medicare Advantage plans then submit bids, or estimates, of what they expect their plans to spend on the average county enrollee. If a plan’s spending estimate is above the benchmark, enrollees pay the difference as a Part C premium.

Most plans’ spending estimates are below the benchmark, however, meaning they project that the plans will provide coverage that is equivalent to traditional Medicare at a lower cost than the benchmark. These plans don’t charge patients a Part C premium. Instead, they receive a portion of the difference between their spending estimate and the benchmark as a rebate that they are supposed to pass on to their enrollees as extras, like reductions in cost-sharing, lower prescription drug premiums and supplemental benefits.

Finally, in a process known as risk adjustment, Medicare payments to Medicare Advantage health plans are adjusted based on the health of their enrollees. The plans are paid more for enrollees who seem sicker.

Two sets of stacked boxes sit below a vertical bar labeled Risk-Adjusted Benchmark. A vertical line bisecting the boxes is labelled what Medicare would actually spend on an enrollee in traditional Medicare

The government pays Medicare Advantage plans based on Medicare’s cost estimates for a given county. The benchmark is an estimate from the Centers for Medicare & Medicaid Services of what it would cost to cover an average county enrollee in traditional Medicare, plus adjustments including quartile payments and quality bonuses. The risk-adjusted benchmark also takes into consideration an enrollee’s health.

Samantha Randall at USC, CC BY-ND

Theory versus reality

In theory, this payment system should save the Medicare system money because the risk-adjusted benchmark that Medicare estimates for each plan should run, on average, equal to what Medicare would actually spend on a plan’s enrollees if they had enrolled in traditional Medicare instead.

In reality, the risk-adjusted benchmark estimates are far above traditional Medicare costs. This causes Medicare – really, taxpayers – to spend more for each person who is enrolled in Medicare Advantage than if that person had enrolled in traditional Medicare.

Why are payment estimates so high? There are two main culprits: benchmark modifications designed to encourage Medicare Advantage plan availability, and risk adjustments that overestimate how sick Medicare Advantage enrollees are.

Two sets of stacked boxes with dotted arrows on the left side of each labeled Medicare Advantage Plan Bid sit below vertical bars labeled Benchmark and Risk-Adjusted Benchmark.

High risk-adjusted benchmarks lead to overpayments from the government to the private companies that administer Medicare Advantage plans.

Samantha Randall at USC, CC BY-ND

Benchmark modifications

Since the current Medicare Advantage payment system started in 2006, policymaker modifications have made Medicare’s benchmark estimates less tied to what the plan spends on each enrollee.

In 2012, as part of the Affordable Care Act, Medicare Advantage benchmark estimates received another layer: “quartile adjustments.” These made the benchmark estimates, and therefore payments to Medicare Advantage companies, higher in areas with low traditional Medicare spending and lower in areas with high traditional Medicare spending. This benchmark adjustment was meant to encourage more equitable access to Medicare Advantage options.

In that same year, Medicare Advantage plans started receiving “quality bonus payments” with plans that have higher “star ratings” based on quality factors such as enrollee health outcomes and care for chronic conditions receiving higher bonuses.

However, research shows that ratings have not necessarily improved quality and may have exacerbated racial inequality.

Even before fully taking into account risk adjustment, recent estimates peg the benchmarks, on average, as 8% higher than average traditional Medicare spending. This means that a Medicare Advantage plan’s spending estimate could be below the benchmark and the plan would still get paid more for its enrollees than it would have cost the government to cover those same enrollees in traditional Medicare.

Overestimating enrollee sickness

The second major source of overpayment is health risk adjustment, which tends to overestimate how sick Medicare Advantage enrollees are.

Each year, Medicare studies traditional Medicare diagnoses, such as diabetes, depression and arthritis, to understand which have higher treatment costs. Medicare uses this information to adjust its payments for Medicare Advantage plans. Payments are lowered for plans with lower predicted costs based on diagnoses and raised for plans with higher predicted costs. This process is known as risk adjustment.

But there is a critical bias baked into risk adjustment. Medicare Advantage companies know that they’re paid more if their enrollees seem more sick, so they diligently make sure each enrollee has as many diagnoses recorded as possible.

This can include legal activities like reviewing enrollee charts to ensure that diagnoses are recorded accurately. It can also occasionally entail outright fraud, where charts are “upcoded” to include diagnoses that patients don’t actually have.

In traditional Medicare, most providers – the exception being Accountable Care Organizations – are not paid more for recording diagnoses. This difference means that the same beneficiary is likely to have fewer recorded diagnoses if they are enrolled in traditional Medicare rather than a private insurer’s Medicare Advantage plan. Policy experts refer to this phenomenon as a difference in “coding intensity” between Medicare Advantage and traditional Medicare.

Human figure with arrows to two boxes. Left box has two plus symbols labelled  recorded diagnoses and one dollar sign. Right box has five symbols and three dollar signs.

The same person is likely to be documented with more illnesses if they enroll in Medicare Advantage rather than traditional Medicare – and cost taxpayers more money.

Samantha Randall at USC, CC BY-ND

In addition, Medicare Advantage plans often try to recruit beneficiaries whose health care costs will be lower than their diagnoses would predict, such as someone with a very mild form of arthritis. This is known as “favorable selection.”

The differences in coding and favorable selection make beneficiaries look sicker when they enroll in Medicare Advantage instead of traditional Medicare. This makes cost estimates higher than they should be. Research shows that this mismatch – and resulting overpayment – is likely only going to get worse as Medicare Advantage grows.

Where the money goes

Some of the excess payments to Medicare Advantage are returned to enrollees through extra benefits, funded by rebates. Extra benefits include cost-sharing reductions for medical care and prescription drugs, lower Part B and D premiums, and extra “supplemental benefits” like hearing aids and dental care that traditional Medicare doesn’t cover.

Medicare Advantage enrollees may enjoy these benefits, which could be considered a reward for enrolling in Medicare Advantage, which, unlike traditional Medicare, has prior authorization requirements and limited provider networks.

However, according to some policy experts, the current means of funding these extra benefits is unnecessarily expensive and inequitable.

It also makes it difficult for traditional Medicare to compete with Medicare Advantage.

Traditional Medicare, which tends to cost the Medicare program less per enrollee, is only allowed to provide the standard Medicare benefits package. If its enrollees want dental coverage or hearing aids, they have to purchase these separately, alongside a Part D plan for prescription drugs and a Medigap plan to lower their deductibles and co-payments.

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Medicare Advantage plans offer extras, but at a high cost to the Medicare system – and taxpayers. Only 50-60 cents of a dollar spent is returned to enrollees as decreased costs or increased benefits.

AP Photo/Pablo Martinez Monsivais

The system sets up Medicare Advantage plans to not only be overpaid but also be increasingly popular, all on the taxpayers’ dime. Plans heavily advertise to prospective enrollees who, once enrolled in Medicare Advantage, will likely have difficulty switching into traditional Medicare, even if they decide the extra benefits are not worth the prior authorization hassles and the limited provider networks. In contrast, traditional Medicare typically does not engage in as much direct advertising. The federal government only accounts for 7% of Medicare-related ads.

At the same time, some people who need more health care and are having trouble getting it through their Medicare Advantage plan – and are able to switch back to traditional Medicare – are doing so, according to an investigation by The Wall Street Journal. This leaves taxpayers to pick up care for these patients just as their needs rise.

Where do we go from here?

Many researchers have proposed ways to reduce excess government spending on Medicare Advantage, including expanding risk adjustment audits, reducing or eliminating quality bonus payments or using more data to improve benchmark estimates of enrollee costs. Others have proposed even more fundamental reforms to the Medicare Advantage payment system, including changing the basis of plan payments so that Medicare Advantage plans will compete more with each other.

Reducing payments to plans may have to be traded off with reductions in plan benefits, though projections suggest the reductions would be modest.

There is a long-running debate over what type of coverage should be required under both traditional Medicare and Medicare Advantage. Recently, policy experts have advocated for introducing an out-of-pocket maximum to traditional Medicare. There have also been multiple unsuccessful efforts to make dental, vision, and hearing services part of the standard Medicare benefits package.

Although all older people require regular dental care and many of them require hearing aids, providing these benefits to everyone enrolled in traditional Medicare would not be cheap. One approach to providing these important benefits without significantly raising costs is to make these benefits means-tested. This would allow people with lower incomes to purchase them at a lower price than higher-income people. However, means-testing in Medicare can be controversial.

There is also debate over how much Medicare Advantage plans should be allowed to vary. The average Medicare beneficiary has over 40 Medicare Advantage plans to choose from, making it overwhelming to compare plans. For instance, right now, the average person eligible for Medicare would have to sift through the fine print of dozens of different plans to compare important factors, such as out-of-pocket maximums for medical care, coverage for dental cleanings, cost-sharing for inpatient stays, and provider networks.

Although millions of people are in suboptimal plans, 70% of people don’t even compare plans, let alone switch plans, during the annual enrollment period at the end of the year, likely because the process of comparing plans and switching is difficult, especially for older Americans.

MedPAC, a congressional advising committee, suggests that limiting variation in certain important benefits, like out-of-pocket maximums and dental, vision and hearing benefits, could help the plan selection process work better, while still allowing for flexibility in other benefits. The challenge is figuring out how to standardize without unduly reducing consumers’ options.

The Medicare Advantage program enrolls over half of Medicare beneficiaries. However, the $83-billion-per-year overpayment of plans, which amounts to more than 8% of Medicare’s total budget, is unsustainable. We believe the Medicare Advantage payment system needs a broad reform that aligns insurers’ incentives with the needs of Medicare beneficiaries and American taxpayers.

This article is part of an occasional series examining the U.S. Medicare system.

Past articles in the series:

Medicare vs. Medicare Advantage: sales pitches are often from biased sources, the choices can be overwhelming and impartial help is not equally available to allThe Conversation

Grace McCormack, Postdoctoral researcher of Health Policy and Economics, University of Southern California and Erin Duffy, Research Scientist and Director of Research Training in Health Policy and Economics, University of Southern California

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How to navigate the evolving parent-child relationship as kids become adults

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theconversation.com – Amy Root, Professor of Applied Human Sciences, West Virginia University – 2024-11-25 15:46:00

Emerging adult children and their parents can experience growing pains as they navigate a changing relationship.
AJ_Watt/E+ via Getty Images

Amy Root, West Virginia University

As a professor of child development and family science, every year I witness college students heading home for the holidays after a few months of relative independence. Anecdotally, most students express excitement about returning home and say they’re looking forward to relaxing with family and friends.

However, it also can present a challenge for parents and their grown children. Parents may wonder: “What should I expect of my child when they return home after living away?” Adult children may be thinking: “I’m an adult, but I’m in my parents’ home. Do I need to ask permission to go out? Do I have a curfew?”

The adult child’s return home, even for a few days or weeks, may produce some stress for both generations. But, the parent-child relationship is always evolving, including negotiating – and renegotiating – power and control as children age.

In fact, families have been preparing for these new role changes for years. Think about when children enter middle school. They spend less time under their parents’ direct supervision. Parents must begin to find ways to stay connected with their children while encouraging independence. The challenge is the same with young adults, only their interests and the appropriate level of independence has changed.

Generally speaking, the parent-child relationship is relatively stable over time. And the good news is that most people navigate this transition successfully. Understanding a bit more about what developmental and family scientists know about this time of life might help ease the path forward.

Between adolescence and true adulthood

Many countries and societies consider you an adult once you turn 18. However, neuroscience research reveals that parts of the brain that are crucial for adult skills such as planning ahead, decision-making and controlling impulses do not finish developing until the mid- or late 20s. So, from a psychological perspective, the onset of adulthood is not universal and not determined by a specific age.

In 2000, psychologists introduced the concept of a period of development that spans ages 18 to 25: emerging adulthood. It’s a kind of in-between period, when people say they don’t feel fully adult.

It’s important to note that this developmental period is not something that everyone experiences. It’s most common in Western or industrialized countries, though there is research on the experiences of emerging adults in other cultures. This period of exploration and experimentation, however, is a luxury not available to all, with adolescents from lower socioeconomic backgrounds reaching milestones of adulthood such as financial independence or parenthood earlier than those from more affluent backgrounds.

But this life stage has become increasingly common in the 21st century, partly due to societal changes that give young adults more opportunities to explore identity and focus on themselves. For instance, the availability of birth control made sex without marriage more feasible for young adults. Many people take time before full-time work to pursue higher education. Today’s young adults can experiment with ideas and opportunities that weren’t available to them during adolescence.

older man argues with younger man with older woman looking on
Emerging adulthood can bring conflict as family members renegotiate roles and expectations.
FG Trade Latin/E+ via Getty Images

You can probably imagine why emerging adult children and their parents might butt heads when under the same roof. The two generations’ differing opinions and ideals can set up conflict, especially when the child feels like an adult but the parent still sees them as a child. If parents can keep in mind that these young adult offspring are still navigating a distinct developmental phase, it may help them be supportive during this stage.

Relating adult to adult

When children leave the nest, the parent-child relationship goes through a period of adjustment. This is typical and, importantly, a necessary part of becoming an adult.

There’s likely to be a bit of trial and error for both the parent and the child as they figure out how to establish new ways of connecting and relating. But this isn’t the first time in a child’s life that a developmental transition has triggered the need for renegotiating the parent-child relationship. During adolescence, parents begin to provide their children with more freedom to make independent decisions; this requires parent and child to make adjustments in how they interact and relate to one another.

Psychology researchers point to several qualities of healthy parent-adult child relationships. Parents need to get comfortable with a low level of control over what their grown kids do. Parents can expect to know less about their adult child’s whereabouts when out for an evening and whom their adult child spends time with, something that parents monitor during adolescence. Maintaining a warm dynamic and encouraging independence are also key. Together, these attributes help parents promote success in their adult children, helping them grow into mentally healthy and well-adjusted members of society.

These tweaks in approach may initially be uncomfortable for parents. But with a little effort, they can successfully make this transition. It helps if they’ve maintained a good relationship with their kid all along. Psychologists typically define effective parenting during emerging adulthood as a relationship characterized by providing warm emotional support; supporting the child in making their own decisions; and refraining from using guilt to change a child’s beliefs.

Practical tips for evolving relationships

1. Be flexible and don’t compare. Every family is different, and each will navigate adult children returning home in unique ways. Likewise, there may be a need to adjust – and readjust – expectations and rules. Be comfortable with tweaking things to best suit your family.

2. Prepare by connecting. Discuss expectations from both generations before or shortly after the adult child returns home. Being proactive with communication will provide opportunities to connect and find common ground.

3. Establish boundaries and guardrails. Parents should communicate house rules for their adult children, and adult children should state their preferred boundaries. These guardrails should be developmentally appropriate and based on mutual respect.

4. Adjust expectations as needed. Parents should keep in mind that their child is in transition to adulthood. They should expect behavior that reflects having one foot in adolescence and the other in adulthood.

older man and younger man smiling and each with arm around the other
A healthy parent-adult child relationship can be rewarding and fun.
FOTOGRAFIA INC./E+ via Getty Images

Warm, supportive parenting continues to be a good influence on development through the emerging adulthood years. Therefore, it is not surprising that emerging adults continue to seek guidance from their parents. Most parents and adult children find their new, more egalitarian relationship lets them connect in new, more mature ways.The Conversation

Amy Root, Professor of Applied Human Sciences, West Virginia University

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Opioid-free surgery treats pain at every physical and emotional level

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theconversation.com – Heather Margonari, Lead Coordinator for the Opioid Free Pathway, University of Pittsburgh – 2024-11-25 07:42:00

Opioids have been an essential part of anesthesia, but they aren’t the only way to manage pain.

Hispanolistic/E+ via Getty Images

Heather Margonari, University of Pittsburgh; Jacques E. Chelly, University of Pittsburgh, and Shiv K. Goel, University of Pittsburgh

The opioid crisis remains a significant public health challenge in the United States. In 2022, over 2.5 million American adults had an opioid use disorder, and opioids accounted for nearly 76% of overdose deaths.

Some patients are fearful of using opioids after surgery due to concerns about dependence and potential side effects, even when appropriately prescribed by a doctor to manage pain. Surgery is often the first time patients receive an opioid prescription, and their widespread use raises concerns about patients becoming long-term users. Leftover pills from a patient’s prescriptions may also be misused.

Researchers like us are working to develop a personalized and comprehensive surgical experience that doesn’t use opioids. Our approach to opioid-free surgery addresses both physical and emotional well-being through effective anesthesia and complementary pain-management techniques.

What is opioid-free anesthesia?

Clinicians have used morphine and other opioids to manage pain for thousands of years. These drugs remain integral to anesthesia.

Most surgical procedures use a strategy called balanced anesthesia, which combines drugs that induce sleep and relax muscles with opioids to control pain. However, using opioids in anesthesia can lead to unwanted side effects, such as serious cardiac and respiratory problems, nausea and vomiting, and digestive issues.

Concerns over these adverse effects and the opioid crisis have fueled the development of opioid-free anesthesia. This approach uses non-opioid drugs to relieve pain before, during and after surgery while minimizing the risk of side effects and dependency. Studies have shown that opioid-free anesthesia can provide similar levels of pain relief to traditional methods using opioids.

Opioid-free anesthesia is currently based on a multimodal approach. This means treatments are designed to target various pain receptors beyond opioid receptors in the spinal cord. Multimodal analgesia uses a combination of at least two medications or anesthetic techniques, each relieving pain through distinct mechanisms. The aim is to effectively block or modulate pain signals from the brain, spinal cord and the nerves of the body.

Close-up of IV bag with other medical equipment in the background out of focus

Balanced anesthesia combines a number of different drugs to ensure a smooth surgery.

bymuratdeniz/E+ via Getty Images

For instance, nonsteroidal anti-inflammatory drugs, or NSAIDs, such as ibuprofen work by inhibiting COX enzymes that promote inflammation. Acetaminophen, or Tylenol, similarly inhibits COX enzymes. While both acetaminophen and NSAIDs primarily target pain at the surgical site, they can also exert effects at the spinal level after several days of use.

A class of drugs called gabapentinoids, which include gabapentin and pregabalin, target certain proteins to dampen nerve signal transmission. This decreases neuropathic pain by reducing nerve inflammation.

The anesthetic ketamine disrupts pain pathways that contribute to a condition called central sensitization. This disorder occurs when nerve cells in the spinal cord and brain amplify pain signals even when the original injury or source of pain has healed. As a result, normal sensations such as light touch or mild pressure may be perceived as painful, and painful stimuli may feel more intense than usual. By lessening pain sensitivity, ketamine can help reduce the risk of chronic pain.

Regional anesthesia involves injecting local anesthetics near nerves to block pain signals to the brain. This method allows patients to remain awake but pain-free in the numbed area, reducing the need for general anesthesia and its side effects. Common regional techniques include epidurals, spinal anesthesia and nerve blocks.

By activating different pain pathways simultaneously, multimodal approaches aim to enhance pain relief synergistically.

Psychology of pain perception

Psychological factors can significantly influence a patient’s perception of pain. Research indicates that mental health conditions such as anxiety, depression and sleep disturbances can increase pain levels by up to 50%. This suggests that addressing mood and sleep issues can be essential for pain management and improving overall patient well-being.

Psychological states can intensify the perception of pain by significantly influencing the neural pathways related to pain processing. For example, anxiety and stress activate the body’s fight or flight response, prompting the release of stress hormones that heighten nerve sensitivity. This can make pain feel more intense. Research has also found that higher anxiety levels before surgery are linked to increased anesthesia use during surgery and opioid consumption after surgery.

Patient lying on operating table under blanket, smiling up at provider

Addressing pain before an operation can make patients feel better post-op.

ljubaphoto/E+ via Getty Images

Complementary and alternative techniques that address psychological factors can reduce pain and opioid use by modulating pain transmission in the nervous system and activating neurochemical pathways that promote pain relief.

For example, aromatherapy uses essential oils to stimulate the olfactory system. This can help reduce pain perception and enhance overall well-being by evoking emotional responses and promoting relaxation.

Music therapy stimulates the auditory system, which can distract patients from pain, lower anxiety levels and foster emotional healing. This can ultimately lead to reduced pain perception.

Relaxation exercises, such as deep breathing and progressive muscle relaxation, activate the parasympathetic nervous system and help promote a state of rest. Engaging the parasympathetic system helps the body conserve energy, slow your heart rate, lower blood pressure and relieve muscle tension. This can lead to decreased pain sensitivity by promoting a state of calmness.

Acupuncture involves inserting thin needles into specific body points, stimulating the release of endorphins and other neurotransmitters. These molecules can interrupt pain signals and promote healing processes within the body.

Moving toward opioid-free surgery

Transitioning away from opioids in surgery requires a shift in both practice and mindset across the entire health care team. Beyond anesthesiologists, other providers, including surgeons, nurses and medical trainees, also use opioids in patient care. All providers would need to be open to using alternative pain management techniques throughout the surgical process.

In response to the increasing patient demand for opioid-free surgical care, our team at the University of Pittsburgh Medical Center launched the patient-initiated Opioid-Free Surgical Pain Management Program in May 2024. To address both the physical and emotional dimensions of pain while optimizing recovery and safety, we recruited surgeons, anesthesiologists, nurses, pharmacists and hospital administrators to participate in the initiative.

Over the course of six months, our team enrolled 109 patients, 79 of whom successfully underwent surgeries without opioids. Barriers to participating in the program included patient perception of severe pain, inadequately addressing stress and anxiety before the operation and limited education in the department about the program.

However, subsequent refinements to the program – such as giving patients muscle relaxants while they were recovering from anesthesia – improved participation and reduced opioid use. Importantly, none of the 19 patients who received opioids while recovering in the hospital post-op required further opioid prescriptions at discharge.

These results reflect the promise of our pathway to minimize reliance on opioids while ensuring effective pain management. Enhanced psychological support for patients and education for providers in surgery departments can broaden the effectiveness of a comprehensive approach to managing pain.The Conversation

Heather Margonari, Lead Coordinator for the Opioid Free Pathway, University of Pittsburgh; Jacques E. Chelly, Professor of Anesthesiology, Perioperative Medicine and Orthopedic Surgery, University of Pittsburgh, and Shiv K. Goel, Clinical Associate Professor of Anesthesiology, University of Pittsburgh

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