Connect with us

The Conversation

New technique uses near-miss particle physics to peer into quantum world − two physicists explain how they are measuring wobbling tau particles

Published

on

New technique uses near-miss particle physics to peer into quantum world − two physicists explain how they are measuring wobbling tau particles

The Large Hadron Collider at CERN can be used to study many kinds of fundamental particles, including mysterious and rare tau particles.
Oxygen/Moment via Getty Images

Jesse Liu, University of Cambridge and Dennis V. Perepelitsa, University of Colorado Boulder

One way physicists seek clues to unravel the mysteries of the universe is by smashing matter together and inspecting the debris. But these types of destructive experiments, while incredibly informative, have limits.

We are two scientists who study nuclear and particle physics using CERN’s Large Hadron Collider near Geneva, Switzerland. Working with an international group of nuclear and particle physicists, our team realized that hidden in the data from previous studies was a remarkable and innovative experiment.

In a new paper published in Physical Review Letters, we developed a new method with our colleagues for measuring how fast a particle called the tau wobbles.

Our novel approach looks at the times incoming particles in the accelerator whiz by each other rather than the times they smash together in head-on collisions. Surprisingly, this approach enables far more accurate measurements of the tau particle’s wobble than previous techniques. This is the first time in nearly 20 years scientists have measured this wobble, known as the tau magnetic moment, and it may help illuminate tantalizing cracks emerging in the known laws of physics.

A diagram showing a particle wobbling off of a vertical axis.
Electrons, muons and taus all wobble in a magnetic field like a spinning top. Measuring the wobbling speed can provide clues into quantum physics.
Jesse Liu, CC BY-ND

Why measure a wobble?

Electrons, the building blocks of atoms, have two heavier cousins called the muon and the tau. Taus are the heaviest in this family of three and the most mysterious, as they exist only for minuscule amounts of time.

Interestingly, when you place an electron, muon or tau inside a magnetic field, these particles wobble in a manner similar to how a spinning top wobbles on a table. This wobble is called a particle’s magnetic moment. It is possible to predict how fast these particles should wobble using the Standard Model of particle physics – scientists’ best theory of how particles interact.

Since the 1940s, physicists have been interested in measuring magnetic moments to reveal intriguing effects in the quantum world. According to quantum physics, clouds of particles and antiparticles are constantly popping in and out of existence. These fleeting fluctuations slightly alter how fast electrons, muons and taus wobble inside a magnetic field. By measuring this wobble very precisely, physicists can peer into this cloud to uncover possible hints of undiscovered particles.

A chart showing the basic particles.
Electrons, muons and taus are three closely related particles in the Standard Model of particle physics – scientists’ current best description of the fundamental laws of nature.
MissMJ, Cush/Wikimedia Commons

Testing electrons, muons and taus

In 1948, theoretical physicist Julian Schwinger first calculated how the quantum cloud alters the electron’s magnetic moment. Since then, experimental physicists have measured the speed of the electron’s wobble to an extraordinary 13 decimal places.

The heavier the particle, the more its wobble will change because of undiscovered new particles lurking in its quantum cloud. Since electrons are so light, this limits their sensitivity to new particles.

Muons and taus are much heavier but also far shorter-lived than electrons. While muons exist only for mere microseconds, scientists at Fermilab near Chicago measured the muon’s magnetic moment to 10 decimal places in 2021. They found that muons wobbled noticeably faster than Standard Model predictions, suggesting unknown particles may be appearing in the muon’s quantum cloud.

Taus are the heaviest particle of the family – 17 times more massive than a muon and 3,500 times heavier than an electron. This makes them much more sensitive to potentially undiscovered particles in the quantum clouds. But taus are also the hardest to see, since they live for just a millionth of the time a muon exists.

To date, the best measurement of the tau’s magnetic moment was made in 2004 using a now-retired electron collider at CERN. Though an incredible scientific feat, after multiple years of collecting data that experiment could measure the speed of the tau’s wobble to only two decimal places. Unfortunately, to test the Standard Model, physicists would need a measurement 10 times as precise.

Diagram showing two particles nearly colliding.
Instead of colliding two nuclei head-on to create tau particles, two lead ions can whiz past each other in a near miss and still produce taus.
Jesse Liu, CC BY-ND

Lead ions for near-miss physics

Since the 2004 measurement of the tau’s magenetic moment, physicists have been seeking new ways to measure the tau wobble.

The Large Hadron Collider usually smashes the nuclei of two atoms together – that is why it is called a collider. These head-on collisions create a fireworks display of debris that can include taus, but the noisy conditions preclude careful measurements of the tau’s magnetic moment.

From 2015 to 2018, there was an experiment at CERN that was designed primarily to allow nuclear physicists to study exotic hot matter created in head-on collisions. The particles used in this experiment were lead nuclei that had been stripped of their electrons – called lead ions. Lead ions are electrically charged and produce strong electromagnetic fields.

The electromagnetic fields of lead ions contain particles of light called photons. When two lead ions collide, their photons can also collide and convert all their energy into a single pair of particles. It was these photon collisions that scientists used to measure muons.

These lead ion experiments ended in 2018, but it wasn’t until 2019 that one of us, Jesse Liu, teamed up with particle physicist Lydia Beresford in Oxford, England, and realized the data from the same lead ion experiments could potentially be used to do something new: measure the tau’s magnetic moment.

This discovery was a total surprise. It goes like this: Lead ions are so small that they often miss each other in collision experiments. But occasionally, the ions pass very close to each other without touching. When this happens, their accompanying photons can still smash together while the ions continue flying on their merry way.

These photon collisions can create a variety of particles – like the muons in the previous experiment, and also taus. But without the chaotic fireworks produced by head-on collisions, these near-miss events are far quieter and ideal for measuring traits of the elusive tau.

Much to our excitement, when the team looked back at data from 2018, indeed these lead ion near misses were creating tau particles. There was a new experiment hidden in plain sight!

A long tube in an underground tunnel.
The Large Hadron Collider accelerates particles to incredibly high speeds before trying to smash particles together, but not all attempts result in successful collisions.
Maximilien Brice/CERN, CC BY-SA

First measurement of tau wobble in two decades

In April 2022, the CERN team announced that we had found direct evidence of tau particles created during lead ion near misses. Using that data, the team was also able to measure the tau magnetic moment – the first time such a measurement had been done since 2004. The final results were published on Oct. 12, 2023.

This landmark result measured the tau wobble to two decimal places. Much to our astonishment, this method tied the previous best measurement using only one month of data recorded in 2018.

After no experimental progress for nearly 20 years, this result opens an entirely new and important path toward the tenfold improvement in precision needed to test Standard Model predictions. Excitingly, more data is on the horizon.

The Large Hadron Collider just restarted lead ion data collection on Sept. 28, 2023, after routine maintenance and upgrades. Our team plans to quadruple the sample size of lead ion near-miss data by 2025. This increase in data will double the accuracy of the measurement of the tau magnetic moment, and improvements to analysis methods may go even further.

Tau particles are one of physicists’ best windows to the enigmatic quantum world, and we are excited for surprises that upcoming results may reveal about the fundamental nature of the universe.The Conversation

Jesse Liu, Research Fellow in Physics, University of Cambridge and Dennis V. Perepelitsa, Associate Professor of Physics, University of Colorado Boulder

This article is republished from The Conversation under a Creative Commons license. Read the original article.

The Conversation

Taxpayers spend 22% more per patient to support Medicare Advantage – the private alternative to Medicare that promised to cost less

Published

on

theconversation.com – Grace McCormack, Postdoctoral researcher of Health Policy and Economics, University of Southern California – 2024-11-26 07:38:00

Grace McCormack, University of Southern California and Erin Duffy, University of Southern California

Medicare Advantage – the commercial alternative to traditional Medicare – is drawing down federal health care funds, costing taxpayers an extra 22% per enrollee to the tune of US$83 billion a year.

Medicare Advantage, also known as Part C, was supposed to save the government money. The competition among private insurance companies, and with traditional Medicare, to manage patient care was meant to give insurance companies an incentive to find efficiencies. Instead, the program’s payment rules overpay insurance companies on the taxpayer’s dime.

We are health care policy experts who study Medicare, including how the structure of the Medicare payment system is, in the case of Medicare Advantage, working against taxpayers.

Medicare beneficiaries choose an insurance plan when they turn 65. Younger people can also become eligible for Medicare due to chronic conditions or disabilities. Beneficiaries have a variety of options, including the traditional Medicare program administered by the U.S. government, Medigap supplements to that program administered by private companies, and all-in-one Medicare Advantage plans administered by private companies.

Commercial Medicare Advantage plans are increasingly popular – over half of Medicare beneficiaries are enrolled in them, and this share continues to grow. People are attracted to these plans for their extra benefits and out-of-pocket spending limits. But due to a loophole in most states, enrolling in or switching to Medicare Advantage is effectively a one-way street. The Senate Finance Committee has also found that some plans have used deceptive, aggressive and potentially harmful sales and marketing tactics to increase enrollment.

Baked into the plan

Researchers have found that the overpayment to Medicare Advantage companies, which has grown over time, was, intentionally or not, baked into the Medicare Advantage payment system. Medicare Advantage plans are paid more for enrolling people who seem sicker, because these people typically use more care and so would be more expensive to cover in traditional Medicare.

However, differences in how people’s illnesses are recorded by Medicare Advantage plans causes enrollees to seem sicker and costlier on paper than they are in real life. This issue, alongside other adjustments to payments, leads to overpayment with taxpayer dollars to insurance companies.

Some of this extra money is spent to lower cost sharing, lower prescription drug premiums and increase supplemental benefits like vision and dental care. Though Medicare Advantage enrollees may like these benefits, funding them this way is expensive. For every extra dollar that taxpayers pay to Medicare Advantage companies, only roughly 50 to 60 cents goes to beneficiaries in the form of lower premiums or extra benefits.

As Medicare Advantage becomes increasingly expensive, the Medicare program continues to face funding challenges.

In our view, in order for Medicare to survive long term, Medicare Advantage reform is needed. The way the government pays the private insurers who administer Medicare Advantage plans, which may seem like a black box, is key to why the government overpays Medicare Advantage plans relative to traditional Medicare.

Paying Medicare Advantage

Private plans have been a part of the Medicare system since 1966 and have been paid through several different systems. They garnered only a very small share of enrollment until 2006.

The current Medicare Advantage payment system, implemented in 2006 and heavily reformed by the Affordable Care Act in 2010, had two policy goals. It was designed to encourage private plans to offer the same or better coverage than traditional Medicare at equal or lesser cost. And, to make sure beneficiaries would have multiple Medicare Advantage plans to choose from, the system was also designed to be profitable enough for insurers to entice them to offer multiple plans throughout the country.

To accomplish this, Medicare established benchmark estimates for each county. This benchmark calculation begins with an estimate of what the government-administered traditional Medicare plan would spend on the average county resident. This value is adjusted based on several factors, including enrollee location and plan quality ratings, to give each plan its own benchmark.

Medicare Advantage plans then submit bids, or estimates, of what they expect their plans to spend on the average county enrollee. If a plan’s spending estimate is above the benchmark, enrollees pay the difference as a Part C premium.

Most plans’ spending estimates are below the benchmark, however, meaning they project that the plans will provide coverage that is equivalent to traditional Medicare at a lower cost than the benchmark. These plans don’t charge patients a Part C premium. Instead, they receive a portion of the difference between their spending estimate and the benchmark as a rebate that they are supposed to pass on to their enrollees as extras, like reductions in cost-sharing, lower prescription drug premiums and supplemental benefits.

Finally, in a process known as risk adjustment, Medicare payments to Medicare Advantage health plans are adjusted based on the health of their enrollees. The plans are paid more for enrollees who seem sicker.

Two sets of stacked boxes sit below a vertical bar labeled Risk-Adjusted Benchmark. A vertical line bisecting the boxes is labelled what Medicare would actually spend on an enrollee in traditional Medicare

The government pays Medicare Advantage plans based on Medicare’s cost estimates for a given county. The benchmark is an estimate from the Centers for Medicare & Medicaid Services of what it would cost to cover an average county enrollee in traditional Medicare, plus adjustments including quartile payments and quality bonuses. The risk-adjusted benchmark also takes into consideration an enrollee’s health.

Samantha Randall at USC, CC BY-ND

Theory versus reality

In theory, this payment system should save the Medicare system money because the risk-adjusted benchmark that Medicare estimates for each plan should run, on average, equal to what Medicare would actually spend on a plan’s enrollees if they had enrolled in traditional Medicare instead.

In reality, the risk-adjusted benchmark estimates are far above traditional Medicare costs. This causes Medicare – really, taxpayers – to spend more for each person who is enrolled in Medicare Advantage than if that person had enrolled in traditional Medicare.

Why are payment estimates so high? There are two main culprits: benchmark modifications designed to encourage Medicare Advantage plan availability, and risk adjustments that overestimate how sick Medicare Advantage enrollees are.

Two sets of stacked boxes with dotted arrows on the left side of each labeled Medicare Advantage Plan Bid sit below vertical bars labeled Benchmark and Risk-Adjusted Benchmark.

High risk-adjusted benchmarks lead to overpayments from the government to the private companies that administer Medicare Advantage plans.

Samantha Randall at USC, CC BY-ND

Benchmark modifications

Since the current Medicare Advantage payment system started in 2006, policymaker modifications have made Medicare’s benchmark estimates less tied to what the plan spends on each enrollee.

In 2012, as part of the Affordable Care Act, Medicare Advantage benchmark estimates received another layer: “quartile adjustments.” These made the benchmark estimates, and therefore payments to Medicare Advantage companies, higher in areas with low traditional Medicare spending and lower in areas with high traditional Medicare spending. This benchmark adjustment was meant to encourage more equitable access to Medicare Advantage options.

In that same year, Medicare Advantage plans started receiving “quality bonus payments” with plans that have higher “star ratings” based on quality factors such as enrollee health outcomes and care for chronic conditions receiving higher bonuses.

However, research shows that ratings have not necessarily improved quality and may have exacerbated racial inequality.

Even before fully taking into account risk adjustment, recent estimates peg the benchmarks, on average, as 8% higher than average traditional Medicare spending. This means that a Medicare Advantage plan’s spending estimate could be below the benchmark and the plan would still get paid more for its enrollees than it would have cost the government to cover those same enrollees in traditional Medicare.

Overestimating enrollee sickness

The second major source of overpayment is health risk adjustment, which tends to overestimate how sick Medicare Advantage enrollees are.

Each year, Medicare studies traditional Medicare diagnoses, such as diabetes, depression and arthritis, to understand which have higher treatment costs. Medicare uses this information to adjust its payments for Medicare Advantage plans. Payments are lowered for plans with lower predicted costs based on diagnoses and raised for plans with higher predicted costs. This process is known as risk adjustment.

But there is a critical bias baked into risk adjustment. Medicare Advantage companies know that they’re paid more if their enrollees seem more sick, so they diligently make sure each enrollee has as many diagnoses recorded as possible.

This can include legal activities like reviewing enrollee charts to ensure that diagnoses are recorded accurately. It can also occasionally entail outright fraud, where charts are “upcoded” to include diagnoses that patients don’t actually have.

In traditional Medicare, most providers – the exception being Accountable Care Organizations – are not paid more for recording diagnoses. This difference means that the same beneficiary is likely to have fewer recorded diagnoses if they are enrolled in traditional Medicare rather than a private insurer’s Medicare Advantage plan. Policy experts refer to this phenomenon as a difference in “coding intensity” between Medicare Advantage and traditional Medicare.

Human figure with arrows to two boxes. Left box has two plus symbols labelled  recorded diagnoses and one dollar sign. Right box has five symbols and three dollar signs.

The same person is likely to be documented with more illnesses if they enroll in Medicare Advantage rather than traditional Medicare – and cost taxpayers more money.

Samantha Randall at USC, CC BY-ND

In addition, Medicare Advantage plans often try to recruit beneficiaries whose health care costs will be lower than their diagnoses would predict, such as someone with a very mild form of arthritis. This is known as “favorable selection.”

The differences in coding and favorable selection make beneficiaries look sicker when they enroll in Medicare Advantage instead of traditional Medicare. This makes cost estimates higher than they should be. Research shows that this mismatch – and resulting overpayment – is likely only going to get worse as Medicare Advantage grows.

Where the money goes

Some of the excess payments to Medicare Advantage are returned to enrollees through extra benefits, funded by rebates. Extra benefits include cost-sharing reductions for medical care and prescription drugs, lower Part B and D premiums, and extra “supplemental benefits” like hearing aids and dental care that traditional Medicare doesn’t cover.

Medicare Advantage enrollees may enjoy these benefits, which could be considered a reward for enrolling in Medicare Advantage, which, unlike traditional Medicare, has prior authorization requirements and limited provider networks.

However, according to some policy experts, the current means of funding these extra benefits is unnecessarily expensive and inequitable.

It also makes it difficult for traditional Medicare to compete with Medicare Advantage.

Traditional Medicare, which tends to cost the Medicare program less per enrollee, is only allowed to provide the standard Medicare benefits package. If its enrollees want dental coverage or hearing aids, they have to purchase these separately, alongside a Part D plan for prescription drugs and a Medigap plan to lower their deductibles and co-payments.

Page from text document

Medicare Advantage plans offer extras, but at a high cost to the Medicare system – and taxpayers. Only 50-60 cents of a dollar spent is returned to enrollees as decreased costs or increased benefits.

AP Photo/Pablo Martinez Monsivais

The system sets up Medicare Advantage plans to not only be overpaid but also be increasingly popular, all on the taxpayers’ dime. Plans heavily advertise to prospective enrollees who, once enrolled in Medicare Advantage, will likely have difficulty switching into traditional Medicare, even if they decide the extra benefits are not worth the prior authorization hassles and the limited provider networks. In contrast, traditional Medicare typically does not engage in as much direct advertising. The federal government only accounts for 7% of Medicare-related ads.

At the same time, some people who need more health care and are having trouble getting it through their Medicare Advantage plan – and are able to switch back to traditional Medicare – are doing so, according to an investigation by The Wall Street Journal. This leaves taxpayers to pick up care for these patients just as their needs rise.

Where do we go from here?

Many researchers have proposed ways to reduce excess government spending on Medicare Advantage, including expanding risk adjustment audits, reducing or eliminating quality bonus payments or using more data to improve benchmark estimates of enrollee costs. Others have proposed even more fundamental reforms to the Medicare Advantage payment system, including changing the basis of plan payments so that Medicare Advantage plans will compete more with each other.

Reducing payments to plans may have to be traded off with reductions in plan benefits, though projections suggest the reductions would be modest.

There is a long-running debate over what type of coverage should be required under both traditional Medicare and Medicare Advantage. Recently, policy experts have advocated for introducing an out-of-pocket maximum to traditional Medicare. There have also been multiple unsuccessful efforts to make dental, vision, and hearing services part of the standard Medicare benefits package.

Although all older people require regular dental care and many of them require hearing aids, providing these benefits to everyone enrolled in traditional Medicare would not be cheap. One approach to providing these important benefits without significantly raising costs is to make these benefits means-tested. This would allow people with lower incomes to purchase them at a lower price than higher-income people. However, means-testing in Medicare can be controversial.

There is also debate over how much Medicare Advantage plans should be allowed to vary. The average Medicare beneficiary has over 40 Medicare Advantage plans to choose from, making it overwhelming to compare plans. For instance, right now, the average person eligible for Medicare would have to sift through the fine print of dozens of different plans to compare important factors, such as out-of-pocket maximums for medical care, coverage for dental cleanings, cost-sharing for inpatient stays, and provider networks.

Although millions of people are in suboptimal plans, 70% of people don’t even compare plans, let alone switch plans, during the annual enrollment period at the end of the year, likely because the process of comparing plans and switching is difficult, especially for older Americans.

MedPAC, a congressional advising committee, suggests that limiting variation in certain important benefits, like out-of-pocket maximums and dental, vision and hearing benefits, could help the plan selection process work better, while still allowing for flexibility in other benefits. The challenge is figuring out how to standardize without unduly reducing consumers’ options.

The Medicare Advantage program enrolls over half of Medicare beneficiaries. However, the $83-billion-per-year overpayment of plans, which amounts to more than 8% of Medicare’s total budget, is unsustainable. We believe the Medicare Advantage payment system needs a broad reform that aligns insurers’ incentives with the needs of Medicare beneficiaries and American taxpayers.

This article is part of an occasional series examining the U.S. Medicare system.

Past articles in the series:

Medicare vs. Medicare Advantage: sales pitches are often from biased sources, the choices can be overwhelming and impartial help is not equally available to allThe Conversation

Grace McCormack, Postdoctoral researcher of Health Policy and Economics, University of Southern California and Erin Duffy, Research Scientist and Director of Research Training in Health Policy and Economics, University of Southern California

This article is republished from The Conversation under a Creative Commons license. Read the original article.

Read More

The post Taxpayers spend 22% more per patient to support Medicare Advantage – the private alternative to Medicare that promised to cost less appeared first on theconversation.com

Continue Reading

The Conversation

Tiny laboratories that fit in your hand can rapidly identify pathogens using electricity

Published

on

theconversation.com – Blanca H. Lapizco-Encinas, Professor of Biomedical Engineering, Rochester Institute of Technology – 2024-11-26 07:34:00

Microfluidics makes use of tiny channels to speed up analyses of biomolecules such as DNA and proteins.

Thom Leach/Science Photo Library via Getty Images

Blanca H. Lapizco-Encinas, Rochester Institute of Technology

When you think of electric fields, you likely think of electricity – the stuff that makes modern life possible by powering everything from household appliances to cellphones. Researchers have been studying the principles of electricity since the 1600s. Benjamin Franklin, famous for his kite experiment, demonstrated that lightning was indeed electrical.

Electricity has also enabled major advances in biology. A technique called electrophoresis allows scientists to analyze the molecules of life – DNA and proteins – by separating them by their electrical charge. Electrophoresis is not only commonly taught in high school biology, but it’s also a workhorse of many clinical and research laboratories, including mine.

I am a biomedical engineering professor who works with miniaturized electrophoretic systems. Together, my students and I develop portable versions of these devices that rapidly detect pathogens and help researchers fight against them.

Electrophoresis is a staple in high school classrooms and research labs alike.

What is electrophoresis?

Researchers discovered electrophoresis in the 19th century by applying an electric voltage to clay particles and observing how they migrated through a layer of sand. After further advances during the 20th century, electrophoresis became standard in laboratories.

To understand how electrophoresis works, we first need to explain electric fields. These are invisible forces that electrically charged particles, such as protons and electrons, exert on each other. A particle with a positive electrical charge, for example, would be attracted toward a particle with a negative charge. The law of “opposites attract” applies here. Molecules can also have a charge; whether it’s more positive or negative depends on the types of atoms that make it up.

In electrophoresis, an electric field is generated between two electrodes connected to a power supply. One electrode has a positive charge and the other has a negative charge. They are positioned on opposite sides of a container filled with water and a little bit of salt, which can conduct electricity.

When charged molecules such as DNA and proteins are present in the water, the electrodes create a force field between them that pushes the charged particles toward the oppositely charged electrode. This process is called electrophoretic migration.

Illustration of an electrophoresis system, where negatively charged pathogens migrate towards the positively charged electrode

Pathogens have distinct electrical charges and can be separated by measuring how quickly they move through electrophoresis.

Blanca H. Lapizco-Encinas, CC BY-SA

Researchers like electrophoresis because it is fast and flexible. Electrophoresis can help analyze distinct types of particles, from molecules to microbes. Further, electrophoresis can be carried out with materials such as paper, gels and thin tubes.

In 1972, physicist Stanislav Dukhin and his colleagues observed another type of electrophoretic migration called nonlinear electrophoresis that could separate particles not only by their electrical charge but also by their size and shape.

Electric fields and pathogens

Further advancements in electrophoresis have made it a useful tool to fight pathogens. In particular, the microfluidics revolution made possible the tiny laboratories that allow researchers to rapidly detect pathogens.

In 1999, researchers found that these tiny electrophoresis systems could also separate intact pathogens by differences in their electrical charge. They placed a mixture of several types of bacteria in a very thin glass capillary that was then exposed to an electric field. Some bacteria exited the device faster than others due to their distinct electrical charges, making it possible to separate the microbes by type. Measuring their migration speeds allowed scientists to identify each species of bacteria present in the sample through a process that took less than 20 minutes.

Microfluidics improved this process even further. Microfluidic devices are small enough to fit in the palm of your hand. Their miniature size allows them to perform analyses much faster than conventional laboratory equipment because particles don’t need to travel that far through the device to be analyzed. This means the molecules or pathogens researchers are looking for are more easily detected and less likely to be lost during analysis.

Clear rectangular piece of glass around five centimeters long, with two blue lines intersecting like a cross with wells at each point

This is an example of a microfluidic electrophoresis device the author uses in her lab.

Alaleh Vaghef-Koodehi, CC BY-SA

For example, samples analyzed using conventional electrophoresis systems would need to travel through capillary tubes that are about 11 to 31 inches (30 to 80 centimeters) long. These can take 40 to 50 minutes to process and are not portable. In comparison, samples analyzed with tiny electrophoresis systems migrate through microchannels that are only 0.4 to 2 inches (1 to 5 centimeters) long. This translates to small, portable devices with analysis times of about two to three minutes.

Nonlinear electrophoresis has enabled more powerful devices by allowing researchers to separate and detect pathogens by their size and shape. My lab colleagues and I showed that combining nonlinear electrophoresis with microfluidics can not only separate distinct types of bacterial cells but also live and dead bacterial cells.

Tiny electrophoresis systems in medicine

Microfluidic electrophoresis has the potential to be useful across industries. Primarily, these small systems can replace conventional analysis methods with faster results, greater convenience and lower cost.

For example, when testing the efficacy of antibiotics, these tiny devices could help researchers quickly tell whether pathogens are dead after treatment. It could also help doctors decide which drug is most appropriate for a patient by quickly distinguishing between normal bacteria and antibiotic-resistant bacteria.

My lab is also working on developing microelectrophoresis systems for purifying bacteriophage viruses that can be used to treat bacterial infections.

With further development, the power of electric fields and microfluidics can speed up how researchers detect and fight pathogens.The Conversation

Blanca H. Lapizco-Encinas, Professor of Biomedical Engineering, Rochester Institute of Technology

This article is republished from The Conversation under a Creative Commons license. Read the original article.

Read More

The post Tiny laboratories that fit in your hand can rapidly identify pathogens using electricity appeared first on theconversation.com

Continue Reading

The Conversation

How to navigate the evolving parent-child relationship as kids become adults

Published

on

theconversation.com – Amy Root, Professor of Applied Human Sciences, West Virginia University – 2024-11-25 15:46:00

Emerging adult children and their parents can experience growing pains as they navigate a changing relationship.
AJ_Watt/E+ via Getty Images

Amy Root, West Virginia University

As a professor of child development and family science, every year I witness college students heading home for the holidays after a few months of relative independence. Anecdotally, most students express excitement about returning home and say they’re looking forward to relaxing with family and friends.

However, it also can present a challenge for parents and their grown children. Parents may wonder: “What should I expect of my child when they return home after living away?” Adult children may be thinking: “I’m an adult, but I’m in my parents’ home. Do I need to ask permission to go out? Do I have a curfew?”

The adult child’s return home, even for a few days or weeks, may produce some stress for both generations. But, the parent-child relationship is always evolving, including negotiating – and renegotiating – power and control as children age.

In fact, families have been preparing for these new role changes for years. Think about when children enter middle school. They spend less time under their parents’ direct supervision. Parents must begin to find ways to stay connected with their children while encouraging independence. The challenge is the same with young adults, only their interests and the appropriate level of independence has changed.

Generally speaking, the parent-child relationship is relatively stable over time. And the good news is that most people navigate this transition successfully. Understanding a bit more about what developmental and family scientists know about this time of life might help ease the path forward.

Between adolescence and true adulthood

Many countries and societies consider you an adult once you turn 18. However, neuroscience research reveals that parts of the brain that are crucial for adult skills such as planning ahead, decision-making and controlling impulses do not finish developing until the mid- or late 20s. So, from a psychological perspective, the onset of adulthood is not universal and not determined by a specific age.

In 2000, psychologists introduced the concept of a period of development that spans ages 18 to 25: emerging adulthood. It’s a kind of in-between period, when people say they don’t feel fully adult.

It’s important to note that this developmental period is not something that everyone experiences. It’s most common in Western or industrialized countries, though there is research on the experiences of emerging adults in other cultures. This period of exploration and experimentation, however, is a luxury not available to all, with adolescents from lower socioeconomic backgrounds reaching milestones of adulthood such as financial independence or parenthood earlier than those from more affluent backgrounds.

But this life stage has become increasingly common in the 21st century, partly due to societal changes that give young adults more opportunities to explore identity and focus on themselves. For instance, the availability of birth control made sex without marriage more feasible for young adults. Many people take time before full-time work to pursue higher education. Today’s young adults can experiment with ideas and opportunities that weren’t available to them during adolescence.

older man argues with younger man with older woman looking on
Emerging adulthood can bring conflict as family members renegotiate roles and expectations.
FG Trade Latin/E+ via Getty Images

You can probably imagine why emerging adult children and their parents might butt heads when under the same roof. The two generations’ differing opinions and ideals can set up conflict, especially when the child feels like an adult but the parent still sees them as a child. If parents can keep in mind that these young adult offspring are still navigating a distinct developmental phase, it may help them be supportive during this stage.

Relating adult to adult

When children leave the nest, the parent-child relationship goes through a period of adjustment. This is typical and, importantly, a necessary part of becoming an adult.

There’s likely to be a bit of trial and error for both the parent and the child as they figure out how to establish new ways of connecting and relating. But this isn’t the first time in a child’s life that a developmental transition has triggered the need for renegotiating the parent-child relationship. During adolescence, parents begin to provide their children with more freedom to make independent decisions; this requires parent and child to make adjustments in how they interact and relate to one another.

Psychology researchers point to several qualities of healthy parent-adult child relationships. Parents need to get comfortable with a low level of control over what their grown kids do. Parents can expect to know less about their adult child’s whereabouts when out for an evening and whom their adult child spends time with, something that parents monitor during adolescence. Maintaining a warm dynamic and encouraging independence are also key. Together, these attributes help parents promote success in their adult children, helping them grow into mentally healthy and well-adjusted members of society.

These tweaks in approach may initially be uncomfortable for parents. But with a little effort, they can successfully make this transition. It helps if they’ve maintained a good relationship with their kid all along. Psychologists typically define effective parenting during emerging adulthood as a relationship characterized by providing warm emotional support; supporting the child in making their own decisions; and refraining from using guilt to change a child’s beliefs.

Practical tips for evolving relationships

1. Be flexible and don’t compare. Every family is different, and each will navigate adult children returning home in unique ways. Likewise, there may be a need to adjust – and readjust – expectations and rules. Be comfortable with tweaking things to best suit your family.

2. Prepare by connecting. Discuss expectations from both generations before or shortly after the adult child returns home. Being proactive with communication will provide opportunities to connect and find common ground.

3. Establish boundaries and guardrails. Parents should communicate house rules for their adult children, and adult children should state their preferred boundaries. These guardrails should be developmentally appropriate and based on mutual respect.

4. Adjust expectations as needed. Parents should keep in mind that their child is in transition to adulthood. They should expect behavior that reflects having one foot in adolescence and the other in adulthood.

older man and younger man smiling and each with arm around the other
A healthy parent-adult child relationship can be rewarding and fun.
FOTOGRAFIA INC./E+ via Getty Images

Warm, supportive parenting continues to be a good influence on development through the emerging adulthood years. Therefore, it is not surprising that emerging adults continue to seek guidance from their parents. Most parents and adult children find their new, more egalitarian relationship lets them connect in new, more mature ways.The Conversation

Amy Root, Professor of Applied Human Sciences, West Virginia University

This article is republished from The Conversation under a Creative Commons license. Read the original article.

Read More

The post How to navigate the evolving parent-child relationship as kids become adults appeared first on theconversation.com

Continue Reading

Trending